Patents Assigned to Pernix Sleep, Inc.
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10251859
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 9, 2019
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 10238620
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: March 26, 2019
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10143676
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: December 4, 2018
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Ultra low dose doxepin and methods of using the same to treat sleep disorders
    Patent number: 9907779
    Abstract: The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep disorders.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: March 6, 2018
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Philip Jochelson, Neil B. Kavey
  • Low-dose doxepin formulations and methods of making and using the same
    Patent number: 9907780
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: March 6, 2018
    Assignee: Pernix Sleep, Inc.
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 9861607
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 9, 2018
    Assignees: Procom One, Inc., Pernix Sleep, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 9801847
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 31, 2017
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of improving the pharmacokinetics of doxepin
    Patent number: 9572814
    Abstract: Methods of improving the pharmacokinetics of doxepin in a patient.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: February 21, 2017
    Assignee: Pernix Sleep, Inc.
    Inventors: Cara Baron Casseday, Elizabeth Ludington, Michael Skinner, Susan E. Dubé, Roberta L. Rogowski, Philip Jochelson, Robert Mansbach
  • Low-dose doxepin formulations and methods of making and using the same
    Patent number: 9532971
    Abstract: The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: January 3, 2017
    Assignee: Pernix Sleep, Inc.
    Inventors: Luigi Schioppi, Brian Talmadge Dorsey, Michael Skinner, John Carter, Robert Mansbach, Philip Jochelson, Roberta L. Rogowski, Cara Baron Casseday, Meredith Perry, Bryan Knox
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 9498462
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: November 22, 2016
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 9486437
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: November 8, 2016
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • LOW-DOSE DOXEPIN FOR TREATMENT OF SLEEP DISORDERS IN ELDERLY PATIENTS
    Publication number: 20160030383
    Abstract: Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe tor elderly individuals.
    Type: Application
    Filed: July 1, 2015
    Publication date: February 4, 2016
    Applicant: PERNIX SLEEP, INC.
    Inventors: Roberta L. Rogowski, Susan Ellen Dube, Philip Jochelson, Neil Barton Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 9107898
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: August 18, 2015
    Assignee: Pernix Sleep, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dube, Philip Jochelson, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 8513299
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: August 20, 2013
    Assignees: Pernix Sleep, Inc., Procom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson