Abstract: A pharmaceutical formulation to treat vaginal conditions in a human patient comprises: at least one active agent; a modified release dosage form which provides extended release of the anti-infective agent upon vaginal administration to the patient; and wherein the formulation, when containing a total dose of the anti-infective agent of about 25 ?g to about 500 mg based on the active agent will produce a plasma concentration versus time curve (ng/mL versus hours) having an area under the curve (AUC) of less than about 600 ng/mL·hr.
Type:
Grant
Filed:
July 23, 2012
Date of Patent:
October 17, 2017
Assignee:
Perrigo Pharma International Designated Activity Company
Inventors:
Thomas C. Riley, R. Saul Levinson, Robert C. Cuca, Elio Mariani