Patents Assigned to Pestka Biomedical Laboratories, Inc.
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Patent number: 7956161Abstract: Disclosed are interferons of Rhesus and Cynomolgus origin and methods of production and use thereof.Type: GrantFiled: April 11, 2008Date of Patent: June 7, 2011Assignee: Pestka Biomedical Laboratories, Inc.Inventors: Michael A. Skawinski, Doranelly Koltchev, Ronald Jubin, William A. Clark, Thomas B. Lavoie, Sidney Pestka
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Patent number: 7129331Abstract: Methods to generate modified polypeptides, modified antibodies, stably phosphorylated modified polypeptides, stably phosphorylated modified antibodies, polynucleotide sequences encoding the polypeptides, and uses thereof are provided. A computer-aided molecular modeling method is also provided to generate modified phosphorylatable polypeptides, particularly monoclonal antibodies (MAbs) for use in the diagnosis and treatment of cancers and other diseases. The corresponding MAbs contain heterologous recognition sites for polypeptide kinases and can be labeled by an identifiable label, such as radio-isotope 32P. The phosphate group(s) attached to the phosphorylated polypeptide is unusually stable due to engineered intramolecular interactions between the phosphate group and its neighbouring groups.Type: GrantFiled: May 31, 2001Date of Patent: October 31, 2006Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka
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Patent number: 6800747Abstract: Modified proteins, modified interferons &agr;'s and &bgr;'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-&agr;-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable, Hu-IFN-&agr;-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-&agr;-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.Type: GrantFiled: November 28, 2000Date of Patent: October 5, 2004Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka
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Patent number: 6747131Abstract: Modified proteins, modified interferons &agr;'s and &bgr;'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-&agr;-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-&agr;-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-&agr;-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.Type: GrantFiled: November 28, 2000Date of Patent: June 8, 2004Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka
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Patent number: 6150503Abstract: Modified proteins, modified interferons .alpha.'s and .beta.'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-.alpha.-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-.alpha.-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-.alpha.-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.Type: GrantFiled: June 7, 1995Date of Patent: November 21, 2000Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka
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Patent number: 5869293Abstract: A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.Type: GrantFiled: June 9, 1995Date of Patent: February 9, 1999Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka
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Patent number: 5789551Abstract: A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.Type: GrantFiled: June 10, 1994Date of Patent: August 4, 1998Assignee: Pestka Biomedical Laboratories, Inc.Inventor: Sidney Pestka