Abstract: Apparatus for handling potentially dangerous materials by an operator, comprising a work head including a main body (2) having first and second work zones therein, the first and second work zones (15, 19) being arranged adjacent one another with a transfer opening (20) therebetween. The apparatus further includes a first access opening (17) for providing access to said first work zone by the operator from externally thereof and a second access opening (21) for providing access to the second work zone (19) by the operator from externally thereof. An air flow generator (85, 86) is provided for withdrawing air from said first work zone and the apparatus further includes liquid spray means (23) comprising a plurality of spray heads (27) arranged so that liquid spray therefrom forms a plurality of liquid barriers or curtains which at least partially surround the second work zone including liquid barriers or curtains across the transfer opening (20) and second access opening (21).