Abstract: The present invention generally relates to T cells that are modified to enhance the efficiency of adoptive cellular therapy by modulating dendritic cell activity, a composition comprising modified T cells, vectors and methods for the treatment of cancer comprising administering modified T cells. In particular, the present invention provides modified T cells for use in adoptive cellular therapies for the treatment of solid tumours.

Abstract: The invention relates to a NCO-terminated urethane preprolymer based on at least a polyol oligomer and a diisocyanate, wherein the polyol oligomer is polyhydroxyalkanoate-diol oligomers (oligoPHA-diol) having a hydroxyl value of more than or equal to 149 mgKOH/g, and the diisocyanate is selected from the list consisting of 1,4-butane diisocyanate (BDI), hexamethylene diisocyanate (6-HDI), dimeryl diisocyanate (DDI), pentamethylene diisocyanate (PDI), L-lysine diisocyanate (LDI), 1,7-heptamethylene diisocyanate (7-HDI), and mixtures thereof. The invention also relates to a method for preparing such a NCO-terminated urethane prepolymer and for a method for preparing polyhydroxyalkanoate-diol oligomers (oligoPHA-diol). The invention also relates to a hemostatic tissue adhesive composition and a hemostatic tissue adhesive. The invention also relates to a kit for the preparation of a hemostatic tissue adhesive.

Abstract: A modular unit for constructing a modular structure is described. The modular unit comprises a structural frame, which includes at least one upper beam, at least one lower beam, and at least one column extending between said upper and lower beams and connected therebetween. At least one of said upper or lower beams is arranged to define at least one chamber for receiving a building material therein along at least a portion of its length, said column being connected to said portion of said beam. Part of said beam is removed along said portion of said beam to define at least one opening to said chamber.

Abstract: A support system includes a base support to be secured in a process chamber of a production system, and includes at least one positioning element. A workpiece holder has upper and lower faces. The workpiece support has at least one first positioning device. The positioning element and the first positioning device form a pin/hole pair. A section of the pin has a first thermal expansion coefficient. A section of the hole controlling positional accuracy has a second thermal expansion coefficient. In a first alternative, the second thermal expansion coefficient is lower than the first, producing a clamping effect between the pin and hole upon temperature increase of the support system. Alternatively, the first thermal expansion coefficient is lower than the second, producing a clamping effect upon temperature increase of the support system. The invention additionally relates to a method for producing a workpiece.

Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: Two-component paint system comprising a binding agent component and a curing agent component which are separated from one another prior to application of the paint system and are brought into contact with one another for application, so that the binding agent in the binder component crosslinks by contact with the curing agent component, with the binder component containing, in addition to the binding agent, at least one solvent which is unreactive with the curing agent component, a crosslinking catalyst and a propellant agent, characterized in that the curing agent component is obtainable by pre-reaction of a deficient amount of a bi- or trifunctional low-molecular-weight active hydrogen-carrying compound with an isocyanate-based crosslinker having a residual content of monomeric or dimeric isocyanates of ?1% w/w, said paint system being contained in a 2K aerosol spray can provided with an inner casing.

Abstract: A process for the production of aluminum salts of a fatty acid, comprising the following steps: a) mixing a fatty acid and an aqueous solution of a strong base to prepare an aqueous base/fatty acid mixture, b) mixing said aqueous base/fatty acid mixture with an aluminum source to prepare an aqueous base/fatty acid/aluminum mixture, c) mixing said aqueous base/fatty acid/aluminum mixture with an acid, and d) separating the produced aluminum salts of the fatty acid.

Abstract: The present application is directed to bispecific polypeptides comprising a first domain binding an antigen on an antigen presenting cell (ARC) and a second domain binding an antigen on an immune cell expressing a chimeric antigen receptor (CAR). Nucleic acids, vectors and host cells used in producing the polypeptide of the invention are also disclosed. Compositions comprising the bispecific polypeptides and methods of treating cancer and stimulating activation and expansion of immune cells in vivo and in vitro are also disclosed.

Abstract: Disclosed is a surgical staple (1) comprising a first jaw (2) and a second jaw (4) designed to pivot relative to each other about a pivot axis (X) in such a way as to clamp biological tissue, in which the first jaw (2) comprises a plurality of teeth (14) suitable for being in contact with the biological tissue clamped by the first jaw (2) and the second jaw (4), the plurality of teeth (14) comprising: a first tooth (14a) having a first surface (28a) that is inclined relative to the pivot axis (X) in a cutting plane parallel to the pivot axis (X) and passing through the first tooth (14a), a second tooth (14b) having a second surface (28b) that is inclined relative to the pivot axis (X), the first surface (28a) and the second surface (28b) being arranged to intersect in a cross-sectional view of the first jaw (2) according to the cutting plane, in which the first tooth (14a) further comprises: a third surface (32a) that is inclined relative to the pivot axis (X), the third surface (32a) being connected to the f

Abstract: The present invention relates generally to a method of detecting a risk of the progression from a pre-invasive neoplasia of the glandular epithelium. More particularly, the present invention provides a method of detecting a risk of the progression from a pre-invasive breast neoplasia by screening for the level of expression of Stefin A in the myoepithelial cells. The method of the present invention is useful in a range of applications including, but not limited to, assessing a neoplastic condition, monitoring the progression of such a condition, predicting the likelihood of a subject progressing to a more advance disease state or informing decisions in relation to the design of treatment schedules.

Abstract: The present invention is defined by having a bucket support configured to support a snow bucket on an ice resurfacing machine. The support includes a plate welded to an intermediate portion of a rod. A handle formed into an upper portion of the rod. A top bracket defined to include a notch sized to receive, for rotation therein, the intermediate portion of the rod. The top bracket further including machine openings to secure the top bracket to a first portion of the ice resurfacing machine. A base bracket configured to secure against a base portion of the ice resurfacing machine. The base bracket including a base opening sized to receive the lower portion of the rod, permitting rotation of the rod therein.

Abstract: A trailer for providing a usable space. The trailer includes a wheeled underframe with a base element which is at least partially open at a top, a roof element with a roof surface and four adjacent side walls, and a connection element which connects the base element to the roof element in a set-up state. The connection element has an upper surface with at least two adjacent, opposite side walls. In a travel state, the roof element surrounds the connection element and the base element from an outside at the top and at least partially at the sides. To provide the set-up state of the trailer, the roof element extends a dimension of the base element by being erected substantially vertically, and the connection element increases a height of the base element by being erected, so as to provide a firmly enclosed usable space in an interior of the trailer.

Abstract: The invention relates compound of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diastereoisomers thereof: wherein W, X, Y and Z are as defined, for use in the treatment of Acute Myeloid Leukemia (AML).

Abstract: A method of creating a processable water soluble polymer, the method comprising the steps of: extruding a water soluble polymer composition from an extruder barrel without use of a die, wherein the extruder barrel is not vented other than via its extruder outlet, to produce an irregularly shaped polymer extrudate; directing the irregularly shaped polymer extrudate onto a chilled conveyor to cool the irregularly shaped polymer extrudate to below 60° C.; and granulating the irregularly shaped polymer extrudate to form a granulate.

Abstract: At least one computer-readable medium on which are stored instructions that, when executed by one or more processing devices, enable the one or more processing devices to perform a method. The method includes the steps of providing over a network a request for first information from a second service provider at a job site characterizing a first service provided by a first service provider at the job site, receiving over the network from the second service provider the first information, providing over the network a request for second information from a third service provider at the job site characterizing a second service provided by the second service provider at the job site, and receiving over the network from the third service provider the second information.

Abstract: A biopsy gun having a cannula and a stylet guided in the cannula comprises the following a housing, a cannula carriage for moving the cannula, a stylet carriage for moving the stylet, a tensioning grip for tensioning the cannula carriage and the stylet carriage from an initial position into a tensioning position, and an engaging member that is provided on the tensioning grip and has recesses adapted to engage with corresponding projections of the cannula carriage and the stylet carriage. The engaging member is rotatably attached to the tensioning grip and is biased by a spring against a contact surface of the housing.

Abstract: A system (100) for handling and storage of containers (200), system (100) comprising a structure (102) having storage cells (104) therein. Cells (104) are configured to store a container (200). Cells (104) are arranged in a rectangular prismatic array comprising a plurality of arrays (A1, A2 . . . A16). Each array comprises columns (C1, C2 . . . C15) and rows (R1, R2 . . . R18). Arrays (A1, A2 . . . A16) are arranged in pairs on opposite sides of void areas (V1, V2 . . . V8), each of which extends vertically and horizontally through the structure (102). Each cell has a container access opening (106) communicating with its associated void area (V1, V2 . . . V8). Container cranes (108) are provided for each void area (V1, V2 . . . V8). Container engagement assemblies (108c) are releasably engaged with respective opposite longitudinal ends of carrier (108a) of cranes (108). Upon movement into a cell (104), assemblies (108c) engage and are vertically supported by horizontal members (102c) at the top of the cell.

Abstract: Estolide esters obtainable by esterification of —hydroxycarboxylic acids having 12 to 24 carbon atoms, the hydroxycarboxylic acids comprising unsaturated hydroxycarboxylic acids having a) —monocarboxylic acids with 6 to 22 carbon atoms and —polyols with at least two hydroxy groups or b) —monoalcohols having 8 to 22 carbon atoms and —linear carboxylic acids having at least two carboxyl groups or c) —monocarboxylic acids having 6 to 22 carbon atoms and —monoalcohols having 8 to 22 carbon atoms.

Abstract: The invention is a method for processing a phonocardiographic signal characterising fetal breathing movement (FBM), wherein in initial start point (SP) determination (S100) in frequency filtering (S110), bandpass-filtered signals of frequency subbands by first and second bandpass filters are generated from the phonocardiographic signal, and first identified SP of an FBM episode is determined in a frequency subband in SP search (S120), in episode discovering (S130) further SP is searched applying the SP search (S120) in episode search time period, and if found at smaller distance from identified SP than a clustering threshold, it is merged with identified SP, if found at larger distance from identified SP than the clustering threshold, an SP closest to identified SP is identified as second identified SP. The invention is, furthermore, a system for processing a phonocardiographic signal characterising FBM. (FIG.

Abstract: A trailer for providing a usable space. The trailer includes a wheeled underframe with a base element which is at least partially open at a top, a roof element with a roof surface and four adjacent side walls, and a connection element which connects the base element to the roof element in a set-up state. The connection element has an upper surface with at least two adjacent, opposite side walls. In a travel state, the roof element surrounds the connection element and the base element from an outside at the top and at least partially at the sides. To provide the set-up state of the trailer, the roof element extends a dimension of the base element by being erected substantially vertically, and the connection element increases a height of the base element by being erected, so as to provide a firmly enclosed usable space in an interior of the trailer.