Patents Assigned to Pevion Biotech Ltd.
  • Virosome-like vesicles comprising gp41-derived antigens
    Patent number: 9216156
    Abstract: The present invention relates to a virosome-like vesicle comprising at least a gp41-derived antigen or an analogue thereof, said gp41-derived antigen being located to the external surface of and/or encapsulated inside said vesicle and being in a convenient configuration for conferring said virosome-like vesicle with an ability to induce an immune response against a gp41 protein or a human immunodeficiency virus (HIV).
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: December 22, 2015
    Assignees: MYMETICS CORPORATION, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), PEVION BIOTECH LTD.
    Inventors: Sylvain Fleury, Morgane Bomsel, Rinaldo Zurbriggen
  • Truncated Secretory Aspartyl Proteinase 2
    Publication number: 20140193445
    Abstract: The present invention relates to an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. The present invention also relates to a composition comprising an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same.
    Type: Application
    Filed: March 19, 2014
    Publication date: July 10, 2014
    Applicants: Istituto Superiore Di Sanita, Pevion Biotech Ltd.
    Inventors: Rinaldo Zurbriggen, Flavia De Bernardis, Antonio Cassone, Silvia Rasi
  • Lyophilization of Virosomes
    Publication number: 20140072616
    Abstract: The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
    Type: Application
    Filed: August 8, 2013
    Publication date: March 13, 2014
    Applicant: Pevion Biotech Ltd.
    Inventors: Rinaldo Zurbriggen, Mario Amacker, Silvia Rasi
  • Trans-adjuvant system
    Patent number: 8496962
    Abstract: The present invention relates to a novel adjuvant system that generates an efficient immune response against antigens of various origins while reducing the risk of toxic side effects attendant to the use of known adjuvants. The novel adjuvant of the present invention comprises virosomes and allows antigenic molecules to be bound to or encapsulated in a variety of delivery vehicles which are easier to prepare for virosomes.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: July 30, 2013
    Assignee: Pevion Biotech, Ltd.
    Inventors: Rinaldo Zurbriggen, Andreas Kammer
  • TRUNCATED SECRETORY ASPARTYL PROTEINASE 2
    Publication number: 20100285109
    Abstract: The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.
    Type: Application
    Filed: September 19, 2008
    Publication date: November 11, 2010
    Applicants: Pevion Biotech Ltd., Istituto Superiore di Sanita
    Inventors: Rinaldo Zurbriggen, Flavia De Bernardis, Antonio Cassone, Silvia Rasi
  • Novel Trans-Adjuvant System
    Publication number: 20100015214
    Abstract: The present invention relates to a novel adjuvant system that generates an efficient immune response against antigens of various origins while reducing the risk of toxic side effects attendant to the use of known adjuvants. The novel adjuvant of the present invention comprises virosomes and allows antigenic molecules to be bound to or encapsulated in a variety of delivery vehicles which are easier to prepare for virosomes.
    Type: Application
    Filed: December 15, 2006
    Publication date: January 21, 2010
    Applicant: PEVION BIOTECH LTD.
    Inventors: Rinaldo Zurbriggen, Andreas Kammer
  • High-Efficiency Fusogenic Vesicles, Methods of Producing Them, and Pharmaceutical Compositions Containing Them
    Publication number: 20090280163
    Abstract: The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides, antigens, pharmaceutical drugs and cosmetic agents to cells and tissues.
    Type: Application
    Filed: February 11, 2008
    Publication date: November 12, 2009
    Applicant: Pevion Biotech Ltd.
    Inventors: Sonia Vadrucci, Joseph Brunner, Rinaldo Zubriggen
  • VIROSOME-LIKE VESICLES COMPRISING GP41-DERIVED ANTIGENS
    Publication number: 20090202622
    Abstract: The present invention relates to a virosome-like vesicle comprising at least a gp41-derived antigen or an analogue thereof, said gp41-derived antigen being located to the external surface of and/or encapsulated inside said vesicle and being in a convenient configuration for conferring said virosome-like vesicle with an ability to induce an immune response against a gp41 protein or a human immunodeficiency virus (HIV).
    Type: Application
    Filed: March 2, 2007
    Publication date: August 13, 2009
    Applicants: MYMETICS CORPORATION, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM), PEVION BIOTECH LTD.
    Inventors: Sylvain Fleury, Morgane Bomsel, Rinaldo Zurbriggen
  • Lyophilization of virosomes
    Publication number: 20080268028
    Abstract: The present invention relates to biologically active compositions and methods for the lyophilization and reconstruction of virosomes comprising special membrane compositions. These compositions are essential to the invention and provide superior freeze-drying stress-resistance for the virosomes of the invention.
    Type: Application
    Filed: June 28, 2007
    Publication date: October 30, 2008
    Applicant: Pevion Biotech Ltd.
    Inventors: Rinaldo Zurbriggen, Mario Amacker, Silvia Rasi
  • PTH-rP related peptide cancer therapeutics
    Patent number: 7378495
    Abstract: Compositions comprising PTH-rP peptides, combinations thereof, and multiepitope PTH-rP peptides, vectors for their delivery to antigen presenting cells, as well as methods are provided which are useful in the immunotherapy of parathyroid hormone related peptide expressing malignancies.
    Type: Grant
    Filed: October 21, 2003
    Date of Patent: May 27, 2008
    Assignee: Pevion Biotech, Ltd.
    Inventors: Pierpaolo Correale, Maria Grazia Cusi, Guido Francini
  • Immunogenic compositions of cyclic peptides derived from the beta-amyloid peptide
    Publication number: 20080107649
    Abstract: The present invention relates to biologically active compositions and methods forelliciting an immune response, particularly against amyloid beta peptides by combinatory use of virosomes as adjuvants and a synthetic beta-peptide antigen.
    Type: Application
    Filed: June 28, 2007
    Publication date: May 8, 2008
    Applicant: Pevion Biotech Ltd.
    Inventor: Rinaldo Zurbriggen
  • High-efficiency fusogenic vesicles, methods of producing them, and pharmaceutical compositions containing them
    Patent number: 7329807
    Abstract: The present invention relates to novel fusogenic vesicles as highly efficient and versatile encapsulation systems for delivering a substance of choice, such as nucleic acids, proteins, peptides, antigens, pharmaceutical drugs and cosmetic agents to cells and tissues.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: February 12, 2008
    Assignee: Pevion Biotech Ltd.
    Inventors: Sonia Vadrucci, Joseph Brunner, Rinaldo Zurbriggen