Patents Assigned to Pfizer Inc.
  • Patent number: 5296002
    Abstract: A form of calcium carbonate having a blocky rhombohedral crystal structure and properties including a surface area of from about 3 to about 15 m.sup.2 g, an average discrete particle size of from about 0.2 to about 0.9 micron, wherein the discrete particles have an aspect ratio less than about, 2:1 and a particle size distribution such that at least about 60 weight percent of the particles have a size within 50 percent of the equivalent discrete particle spherical diameter, suitable for use as a filler material in papermaking to improve the optical properties of the resulting paper, is disclosed. An accelerated heat-aging process, including embodiments thereof which utilize hydrothermal techniques, for rapidly producing this form of calcium carbonate, and a related form of calcium carbonate having a hexagonal prismatic crystal structure and the same properties, in large quantities to meet the demand of the papermaking industry, as well as a method for using these materials in papermaking, are also disclosed.
    Type: Grant
    Filed: December 17, 1990
    Date of Patent: March 22, 1994
    Assignee: Pfizer Inc.
    Inventor: June D. Passaretti
  • Patent number: 5294730
    Abstract: Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings having a total of three nitrogen atoms, one in each ring and one angular nitrogen.
    Type: Grant
    Filed: November 20, 1992
    Date of Patent: March 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Nicholas A. Saccomano, Fredric J. Vinick
  • Patent number: 5294744
    Abstract: A novel two-step reaction process for preparing 5-substituted-2-methoxybenzaldehyde compounds is disclosed wherein the substituent group is either isopropyl or trifluoromethoxy. The process involves (1) reacting a corresponding 4-substituted phenol compound with dimethyl carbonate in the presence of a tertiary-amine base to form the corresponding 4-substituted anisole compound, and (2) thereafter subjecting the latter intermediate product obtained in the first step to aromatic C-formylation on the ring with hexamethylenetetramine in the presence of trifluoroacetic acid, followed by hydrolysis, to ultimately yield the desired aldehyde compound. The two aromatic aldehyde compounds so obtained, viz., 2-methoxy-5-trifluoromethoxybenzaldehyde and 2-methoxy-5-isopropylbenzaldehyde, are known to be useful as intermediates that specifically lead to (2S,3S)-cis-3-(2-methoxy-5-trifluoromethoxybenzyl)amino-2-phenylpiperidine and (2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxy-5-isopropylphenyl)methyl]-1-a zabicyclo[2.2.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: March 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Dennis M. Godek, William M. Synder, Andrew M. Stewart
  • Patent number: 5294635
    Abstract: Certain spirocyclic heterocyclic compounds, and their pharmaceutically-acceptable salts, are inhibitors of the aldose reductase enzyme, and so are useful for the control of diabetic complications.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: March 15, 1994
    Assignee: Pfizer, Inc.
    Inventors: James F. Eggler, Eric R. Larson
  • Patent number: 5294619
    Abstract: A series of novel N-alkyl or oxyalkyl arylpiperidine derivatives have been prepared, including their pharmaceutically acceptable acid addition salts, wherein the N-alkyl or oxyalkyl side chain is further substituted by certain aryl or heterocyclic ring groups. These particular compounds are useful in therapy as neuroleptic agents for the control of various psychotic disorders. Typical and preferred member compounds include 4-{{4-{2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}phenyl}}thiazole-2-amine , 4-{{4-{4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}phenyl}}thiazole-2-a mine, 3-{4-[4-(2-methoxyphenyl)-1-piperidinyl]-n-butyl}-1,8,8-trimethyl-3-azabic yclo[3.2.1]octane-2,4-dione, 5-{2-[4-(2-methoxyphenyl)-1-piperidinyl]ethyl}oxindole and 3-{2-[4-(1-naphthyl)-1-piperidinyl]ethyl}-2-methyl-4H-pyrido[1,2-a]pyrimid ine-4-one, respectively. Methods for preparing all these compounds from known starting materials are provided.
    Type: Grant
    Filed: July 29, 1992
    Date of Patent: March 15, 1994
    Assignee: Pfizer Inc.
    Inventor: Arthur A. Nagel
  • Patent number: 5293942
    Abstract: This invention relates to the use of certain keto and diketo acids, esters and salts that are derived from aldopentoses and aldohexoses, to maintain very high levels of iron in solution under oil well acidizing conditions. The compounds described herein chelate ferric iron at low temperatures and are activated by heat to reduce ferric iron to the more soluble ferrous species at high temperatures. Because of these properties and their extraordinarily high solubility in hydrochloric acid, such compounds are capable of maintaining considerably more iron in solution than competing materials.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: March 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Herman L. Gewanter, Sandra I. Graham, Joseph M. Rashan, Jr., R. Larry Reitz
  • Patent number: 5292749
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: March 8, 1994
    Assignee: Pfizer Inc.
    Inventor: Alan Stobie
  • Patent number: 5290802
    Abstract: This invention relates to novel 3-substituted-2-oxindole derivatives which are inhibitors of prostaglandin H.sub.2 synthase, 5-lipoxygenase and interleukin-1 biosynthesis. The compounds of the invention are useful as inhibitors of prostaglandin H.sub.2 synthase and interleukin-1 biosynthesis, per se, and as analgesic, antiinflammatory and antiarthritic agents in the treatment of chronic inflammatory diseases This invention also relates to pharmaceutical compositions comprising said 3-substituted-2-oxindole derivatives; to methods of inhibiting prostaglandin H.sub.2 synthase and biosynthesis of interleukin-1; and to treating chronic inflammatory diseases in a mammal with said compounds. Further, this invention relates to certain novel carboxylic acids useful as intermediates in the preparation of the 3-substituted-2-oxindole derivatives of this invention and to a process for the preparation of the 3-substituted-2-oxindole derivatives.
    Type: Grant
    Filed: June 5, 1991
    Date of Patent: March 1, 1994
    Assignee: Pfizer Inc.
    Inventors: Frederick J. Ehrgott, Carl J. Goddard, Gary R. Schulte
  • Patent number: 5290788
    Abstract: Alkoxy substituted indole derivatives as inhibitors of lipoxygenase and useful as antiallergy and antiinflammatory agents.
    Type: Grant
    Filed: April 21, 1992
    Date of Patent: March 1, 1994
    Assignee: Pfizer Inc.
    Inventors: Rodney W. Stevens, Hiromasa Morita, Masami Nakane
  • Patent number: 5286857
    Abstract: An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1-yl]acetic acid esters.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: February 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Brian T. O'Neill, Douglas Phillips
  • Patent number: 5286904
    Abstract: Immunoregulatory N-(S-3-alkyl-4-heptenoyl)- and N-(S-3-alkylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine and esters thereof are synthesized via R-trans-2-hexen-4-ols, R-3-alkyl-4-heptanoic acid and S-3-alkylheptanoic acid.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: February 15, 1994
    Assignee: Pfizer Inc.
    Inventor: Charles W. Murtiashaw
  • Patent number: 5284658
    Abstract: Improved means for constraining a rumen drug delivery device in a rolled configuration, said means comprising a laminate, which may be perforated, comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water-dispersible pressure sensitive adhesive to a repulpable tape, said tape having said water-dispersible pressure sensitive adhesive on both its surfaces; a laminate comprising a flexible, water-permeable polymeric material bonded between the low friction surface material and the repulpable tape; and devices constrained by said means.
    Type: Grant
    Filed: June 9, 1992
    Date of Patent: February 8, 1994
    Assignee: Pfizer Inc.
    Inventors: Gautam R. Ranade, Alan C. Curtiss
  • Patent number: 5283249
    Abstract: Coccidioidal agents which contain the polyether antibiotic semduramicin and nicarbazin show synergistic effects in poultry.
    Type: Grant
    Filed: December 7, 1992
    Date of Patent: February 1, 1994
    Assignee: Pfizer Inc.
    Inventor: Jesse E. Shively
  • Patent number: 5281601
    Abstract: A series of novel 3-phenyl-3-[1-(cyclicalkyl)pyrrolidin-3-yl]glutarimide derivatives have been prepared, including their pharmaceutically acceptable salts. The cyclic moiety present in these compounds is derived from either benzene or a heteroaryl such as benzofuran or 2,3-dihydrobenzofuran, or it is derived from an aromatic heterocyclic such as pyridine, pyrazine or thiophene, and it is attached to the adjacent alkyl group of the molecule by means of one of the available ring carbon atoms situated in the aromatic ring of the aforementioned cyclic ring moiety. These particular compounds are useful in therapy as selective muscarinic receptor antagonists, which are selective for smooth muscle muscarinic sites over cardiac muscarinic sites and therefore, are of value in the treatment of diseases associated with altered motility and/or smooth muscle tone as found in the gut, trachea and bladder. Methods for preparing these compounds from known starting materials are provided.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: January 25, 1994
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Alexander R. Mackenzie
  • Patent number: 5280122
    Abstract: This invention relates to a process for resolving racemic or optically enriched 2-benzyl-4-piperidone-succinic acid, comprising reacting such compound with (+)-cis-N-benzyl-2-(hydroxymethyl)-cyclohexylamine, (-)-cis-N-benzyl-2-(hydroxymethyl)-cyclohexylamine or (+)-dehydroabietylamine.
    Type: Grant
    Filed: July 1, 1992
    Date of Patent: January 18, 1994
    Assignee: Pfizer Inc.
    Inventors: Charles K. Chiu, Morgan Meltz
  • Patent number: 5280039
    Abstract: A compound of the formula ##STR1## wherein R is defined herein is useful as an anti-inflammatory agent.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: January 18, 1994
    Assignee: Pfizer Inc.
    Inventor: James F. Eggler
  • Patent number: 5278175
    Abstract: The invention provide antifungal compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF.sub.3 and --OCF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl;X is CH or N; andY is F or Cl.
    Type: Grant
    Filed: October 5, 1992
    Date of Patent: January 11, 1994
    Assignee: Pfizer Inc.
    Inventors: Stephen J. Ray, Kenneth Richardson
  • Patent number: 5276040
    Abstract: Certain 1-substituted 4-(1,2-benzisoxazolyl)-piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.
    Type: Grant
    Filed: June 22, 1992
    Date of Patent: January 4, 1994
    Assignee: Pfizer Inc.
    Inventor: Harry R. Howard, Jr.
  • Patent number: 5272147
    Abstract: Compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof are selective cGMP PDE inhibitors which are useful in the treatment of such diseases and adverse conditions as angina, hypertension, congestive heart failure, reduced blood vessel patency, peripheral vascular disease, stroke, bronchitis, chronic asthma, allergic asthma, allergic rhinitis, glaucoma, and diseases characterized by disorders of gut motility.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: December 21, 1993
    Assignee: Pfizer Inc.
    Inventors: Andrew S. Bell, Nicholas K. Terrett
  • Patent number: 5272160
    Abstract: 2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula ##STR1## wherein Q is S or CH.dbd.CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and Y.sup.1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and Y.sup.1 are taken separately and Y is hydrogen or OH, and Y.sup.1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: August 20, 1992
    Date of Patent: December 21, 1993
    Assignee: Pfizer Inc
    Inventor: Bertrand L. Chenard