Patents Assigned to Pfizer Inc.
  • Patent number: 4797403
    Abstract: 1-Phenylquinazoline-1H,3H-2,4-diones and 1-phenylpyrido-[2,3d]-pyrimidine-1H,3H-2,4-diones, their esters and acid addition salts, and pharmaceutical compositions containing such compounds have antidepressant, anti-inflammatory and analgesic activity.
    Type: Grant
    Filed: July 23, 1987
    Date of Patent: January 10, 1989
    Assignee: Pfizer Inc.
    Inventor: John A. Lowe, III
  • Patent number: 4794179
    Abstract: Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-azetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivaloyloxymethyl esters thereof.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: December 27, 1988
    Assignee: Pfizer Inc.
    Inventors: Robert A. Volkmann, David L. Lindner
  • Patent number: 4792448
    Abstract: A device for zero order releasing of biologically active substances into a fluid medium comprising a cylindrical tablet or bolus covered with an impermeable wall or coating from which strips of said wall or coating have been removed.
    Type: Grant
    Filed: June 11, 1987
    Date of Patent: December 20, 1988
    Assignee: Pfizer Inc.
    Inventor: Gautam R. Ranade
  • Patent number: 4791131
    Abstract: Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for acute administration for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and also for chronic administration for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
    Type: Grant
    Filed: December 31, 1987
    Date of Patent: December 13, 1988
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Patent number: 4791129
    Abstract: 1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.
    Type: Grant
    Filed: November 9, 1987
    Date of Patent: December 13, 1988
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Patent number: 4791125
    Abstract: The present invention relates to certain compounds of the formula ##STR1## wherein the broken line is a bond or no bond, and the pharmaceutically acceptable cationic salts thereof having utility as hypoglycemic and anti-atherosclerosis agents, methods for their use and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: December 13, 1988
    Assignee: Pfizer Inc.
    Inventor: David A. Clark
  • Patent number: 4788196
    Abstract: A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: November 29, 1988
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson
  • Patent number: 4788205
    Abstract: Certain 4-aryl-5-carbamoyl-1,4-dihydropyridines useful in the treatment of allergic and inflammatory conditions in mammals.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: November 29, 1988
    Assignee: Pfizer Inc.
    Inventors: Kelvin Cooper, Michael J. Parry, Peter E. Cross, Kenneth Richardson
  • Patent number: 4785078
    Abstract: A new sulfur-containing polypeptide antibiotic produced by the hydrolysis of thiosporamicin (CP-46,192) is useful for the improving feed utilization efficiency in poultry and swine.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: November 15, 1988
    Assignee: Pfizer Inc.
    Inventors: Eugene F. Fiese, Charles E. Moppett, Wendell W. Windisch
  • Patent number: 4783467
    Abstract: A series of novel heterocyclic-substituted 1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-(1H)-one compounds have been prepared, including their pharmaceutically acceptable salts, wherein the heterocyclic ring moiety is an optionally substituted 5- or 6-membered aromatic heterocyclic group attached to the 6-, 7-, 8- or 9-positions of the aforesaid tetrahydroquinaxolinone ring. These particular compounds are useful in therapy as highly potent inotropic and therefore, are of value in the treatment of various cardiac conditions. Preferred member compounds include 7-(2,4-dimethylimidaxol-1-yl)-9-methyl-1,2,4,5,-tetrahydroimidazo (2,1-b)quinazolin-2-(1H)-one, 3,9-dimethyl-7-(2,4-dimethylimidazol-1-yl) -1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-(1H)-one and 9-methyl-7 -(1,2,4-triazol-4-yl)-1,2,3,5-tetrahydroimidazo(2,1-b)quinazolin-2-(1H)-on e, respectively. Methods for preparing these compounds from known starting materials are provided.
    Type: Grant
    Filed: May 22, 1986
    Date of Patent: November 8, 1988
    Assignee: Pfizer Inc.
    Inventors: Simon F. Campbell, David A. Roberts
  • Patent number: 4782900
    Abstract: Aqueous gel-forming compositions useful for improving oil recovery from subterranean hydrocarbon-containing reservoirs are prepared by reacting an aminoalkylated polyacrylamide with an aldehyde, dialdehyde or derivative thereof in aqueous medium. These compositions are particularly effective in reducing excessive water encroachment at producer wells.
    Type: Grant
    Filed: April 24, 1987
    Date of Patent: November 8, 1988
    Assignee: Pfizer Inc.
    Inventors: Fu-Ning Fung, Raymond C. Glowaky
  • Patent number: 4782050
    Abstract: Antibacterial penicillins of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is a heterocyclic group and R is hydrogen, the residue of certian carboxy protecting groups or the residue of an ester group readily hydrolyzable in vivo having activity against resistant organisms.
    Type: Grant
    Filed: December 4, 1987
    Date of Patent: November 1, 1988
    Assignee: Pfizer Inc.
    Inventor: Yuhpyng L. Chen
  • Patent number: 4782165
    Abstract: In the synthesis of biotin and decarboxybiotin, a more direct method for the conversion of 1,3-diacyl-4-(bromomethyl)-5-[(5-alkoxycarbonylpentanoyl) or hexanoyl]-4-imidazolin-2-ones to 1,3-diacyl-4-[(4-alkoxybutanoyl) or pentanoyl]-1H,3H-thieno (3,4-b)imidazol-2-one via the Bunte salt of the formula ##STR1## wherein R is (C.sub.1 -C.sub.5)alkanoyl or (C.sub.2 -C.sub.5) alkoxycarbonyl, X is methyl or (C.sub.2 -C.sub.5)alkoxycarbonyl an Y is an alkali metal.
    Type: Grant
    Filed: October 1, 1987
    Date of Patent: November 1, 1988
    Assignee: Pfizer Inc.
    Inventor: Constantine Sklavounos
  • Patent number: 4782146
    Abstract: A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
    Type: Grant
    Filed: June 16, 1987
    Date of Patent: November 1, 1988
    Assignee: Pfizer Inc.
    Inventor: Katherine E. Brighty
  • Patent number: 4782145
    Abstract: An efficient process for converting readily available 4-acetoxy-2-azetidinones to allyl 2-thioxopenam-3-carboxylates, intermediates useful for the synthesis of penem antibiotics.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: November 1, 1988
    Assignee: Pfizer Inc.
    Inventors: Katherine E. Brighty, David L. Lindner
  • Patent number: 4777288
    Abstract: A novel three-step process for preparing 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid is disclosed, which involves (1) reducing 4-(3,4-dichlorophenyl)-4-ketobutanoic acid to 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid; (2) then converting the intermediate hydroxy acid formed in the first step to 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone, and (3) thereafter reacting the resulting gamma-butyrolactone compound with benzene in a Friedel-Crafts type reaction to form the desired final product. The latter compound is known to be useful as an intermediate leading to cis-(1S)(4S)- -N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthaleneamine (sertraline), which is known to be a preferred anti-depressant agent in the field of medicinal chemistry. The aforementioned 5-(3,4-dichlorophenyl)-dihydro-2(3H)-furanone and 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid are both novel compounds.
    Type: Grant
    Filed: June 11, 1987
    Date of Patent: October 11, 1988
    Assignee: Pfizer Inc.
    Inventors: George J. Quallich, Michael T. Williams
  • Patent number: 4777270
    Abstract: A series of novel, macrocyclic polyether compounds. The macrocycles have a 21-membered ring, containing six oxygen atoms, and they have a carboxy group (or a salt thereof) directed towards the interior of the ring. Administration of the compounds of the invention to ruminant animals (e.g. cattle and sheep) modifies their digestive fermentation processes such that the volatile fatty acids produced in the rumen contain a higher proportion of propionates rather than acetates, thereby increasing the efficiency of feed utilization in said ruminant animals. Additionally, the compounds of the invention show antibacterial activity in vitro against certain gram-positive microorganisms.
    Type: Grant
    Filed: September 4, 1986
    Date of Patent: October 11, 1988
    Assignee: Pfizer Inc.
    Inventor: Frank J. Urban
  • Patent number: 4775668
    Abstract: Antibacterial compounds have the formula ##STR1## wherein R.sup.1 is hydrogen, a pharmaceutically aceptable cation, or alkyl; A is CH, CF, CCl or N; Y is alkyl, haloalkyl, cyclopropyl, vinyl, methoxy, N-methylamino, p-fluorophenyl, p-hydroxyphenyl or p-aminophenyl; or A is carbon and is taken together with Y and the carbon and nitrogen to which A and Y are attached to form a five to seven membered ring which is optionally substituted; and R.sup.2 is a bridged-diazabicycloalkyl group.
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: October 4, 1988
    Assignee: Pfizer Inc.
    Inventors: Martin R. Jefson, Paul R. McGuirk
  • Patent number: 4772597
    Abstract: Certain 2-azacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R is ##STR2## A is alkylene having 2-4 carbon atoms, alkylene having 2-4 carbon atoms wherein a carbon atom has an oxo substituent or alkylene having 2-4 carbon atoms wherein a methylene is replaced by oxygen, S(O).sub.m, or N--R.sub.3 ;B is carbonyl, thiocarbonyl, methylene or imine;R.sub.1 is hydrogen or forms an ester group which is hydroyzed in vivo;R.sub.2 is hydrogen, formyl, alkylcarbonyl, N-alkylaminocarbonyl, N-alkylaminosulfonyl, aminosulfonyl, aminocarbonyl, alkoxycarbonyl having 2-5 carbon atoms, alkylsulfonyl, alkyl, or alkyl substituted by aminocarbonyl, alkyl--S(O).sub.m --, hydroxyl, amino, alkylcarbonylamino, formamido or alkylsulfonylamino, wherein each alkyl has 1-4 carbon atoms;R.sub.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: September 20, 1988
    Assignee: Pfizer Inc.
    Inventor: Ernest S. Hamanaka
  • Patent number: 4772641
    Abstract: Aqueous gel-forming compositions are prepared by reacting for 1-10 hours at 50.degree.-95.degree. C., melamine, formaldehyde and a sulfurous acid salt with the optional addition of a gel-modifying agent and/or a gelling agent which is added to the composition immediately prior to use.
    Type: Grant
    Filed: June 20, 1985
    Date of Patent: September 20, 1988
    Assignee: Pfizer Inc.
    Inventors: Clifford N. Meltz, Gordon D. Gruetzmacher, Ping W. Chang