Patents Assigned to Pfizer Inc.
  • Antiinflammatory salts of piroxicam
    Patent number: 4567179
    Abstract: Improved antiinflammatory salts of piroxicam with antidepressant doxepin, with bronchodilator pirbuterol or isoproterenol, with H.sub.2 -antagonist inhibitor 2-guanidino-4-(2-methyl-4-imidazolyl)thiazole, with pyridoxine, a member of the vitamin B.sub.6 complex, or with antihypertensive trimazosin.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: January 28, 1986
    Assignee: Pfizer, Inc.
    Inventor: Joseph G. Lombardino
  • Hypoglycemic 5-pyrrolyl, indolyl and quinolyl substituted oxazolidine-2,4-diones and their use
    Patent number: 4565820
    Abstract: Hypoglycemic 5-chromanyl, 2,3-dihydro-5-benzo[b]-furanyl, 5-pyridyl, 5-quinolyl, 5-pyrrolyl, 5-indolyl, 5-thiazolyl, 5-oxazolyl, 5-isothiazolyl and 5-isoxazolyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: January 21, 1986
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur
  • Acyltripeptide immunostimulants
    Patent number: 4565653
    Abstract: Acyltripeptides having the formula below, pharmaceutically acceptable salts thereof and intermediates therefor; processes for their preparation and use as immunostimulant and antibacterial agents. ##STR1## wherein R.degree. is C.sub.1-6 alkyl; x is an integer and is 1 to 4.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: January 21, 1986
    Assignee: Pfizer Inc.
    Inventors: Jeffrey L. Ives, Frank C. Sciavolino
  • Antiinflammatory methods
    Patent number: 4564614
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as piroxicam, or a pharmaceutically acceptable salt thereof, with pyridoxine.
    Type: Grant
    Filed: January 28, 1985
    Date of Patent: January 14, 1986
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Intermediates of hypoglycemic 5-substituted oxazolidine-2,4-diones
    Patent number: 4562267
    Abstract: Variously substituted alkyl 2-(furyl or thienyl)-2-hydroxyacetates and 2-(furyl or thienyl)-2-hydroxyacetamides are useful as intermediates for hypoglycemic oxazolidine-2,4-diones.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: December 31, 1985
    Assignee: Pfizer Inc.
    Inventor: Rodney C. Schnur
  • Animal growth promotant L-pyroglutamyl-pyridylalanyl-L-prolinamides
    Patent number: 4562197
    Abstract: L-pyroglutamyl-pyridylalanyl-L-prolinamides of the formula: ##STR1## wherein R.sup.1 is H, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.7 cycloalkyl, C.sub.2 -C.sub.8 alkoxyalkyl or aryl; and X is H, halo, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; and their physiologically acceptable salts and feed compositions thereof are useful for improving the efficiency of feed utilization and/or growth of animals especially poultry.
    Type: Grant
    Filed: November 13, 1984
    Date of Patent: December 31, 1985
    Assignee: Pfizer Inc.
    Inventors: Michael Snarey, Peter J. Swift, Michael J. Witty
  • 1,3-Bis-(1H-1,2,4-triazol-1-yl)-2-perfluoro-alkylpropan-2-ol antifungal agents
    Patent number: 4560697
    Abstract: Compounds of the formula ##STR1## or a pharmaceutically or agriculturally acceptable acid addition salt thereof wherein R is (C.sub.1 -C.sub.5) perfluoroalkyl and R.sup.1 is H or CH.sub.3, method for their use in combatting fungal infections in plants, seeds and animals, including humans; and as antileishmanial agents, and pharmaceutical and agricultural compositions containing them.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: December 24, 1985
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Peter J. Whittle
  • 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
    Patent number: 4560690
    Abstract: 2,4-Disubstituted thiazole compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, orX is S and Y is CH;R.sup.1 is certain straight or branched chain alkyl groups, (R.sup.3).sub.2 C.sub.6 H.sub.3, or (R.sup.3).sub.2 Ar(CH.sub.2).sub.n where n is an integer from 1 to 4, R.sup.3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups;R.sup.2 is H or (C.sub.1 -C.sub.4)alkyl; orR.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; andR.sup.4 is H, (C.sub.1 -C.sub.5)alkyl, NH.sub.2 or CH.sub.2 OH; a method for their use in treatment of gastric ulcers in mammals and pharmaceutical compositions containing said compounds.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: December 24, 1985
    Assignee: Pfizer Inc.
    Inventor: Lawrence A. Reiter
  • Antiinflammatory compositions and methods
    Patent number: 4559326
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of a non-steroidal antiinflammatory agent such as prioxicam, or a pharmaceutically acceptable salt thereof, with inositol.
    Type: Grant
    Filed: January 31, 1985
    Date of Patent: December 17, 1985
    Assignee: Pfizer Inc.
    Inventors: Thomas C. Crawford, Stanley L. Keely, David L. Larson, Joseph G. Lombardino, James J. Maciejko
  • Method of treating diarrhoea using indole compounds
    Patent number: 4558048
    Abstract: Substituted phenylindoles, useful as anti-diarrhoeal agents and having the formula: ##STR1## and the pharmaceutically-acceptable acid addition salts thereof; wherein R is hydrogen, chloro, bromo, --CH(OH).Ph or --CH(OH).cyclohexyl; each Ph is phenyl or substituted phenyl; n is an integer of from 2 to 7; and each of R.sup.1 and R.sup.2 is hydrogen or (C.sub.1 -C.sub.4) alkyl, or R.sup.1 and R.sup.2 taken together with the nitrogen atom to which they are attached form a heterocyclic group; and a method for the treatment of diarrhoea by the administration of said agents.
    Type: Grant
    Filed: March 27, 1985
    Date of Patent: December 10, 1985
    Assignee: Pfizer Inc.
    Inventor: Robert J. Bass
  • Spiro-3-hetero-azolones for treatment of diabetic complications
    Patent number: 4556670
    Abstract: Spiro-oxazolidones, -thiazolidones and -imidazolidones are disclosed which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes. Pharmaceutical compositions containing the spiro compounds and a method of treating diabetic complications are also disclosed.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventor: Christopher A. Lipinski
  • 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents
    Patent number: 4556672
    Abstract: Certain new 2-oxindole-1-carboxamide compounds having an acyl substituent at the 3-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and in alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.
    Type: Grant
    Filed: December 21, 1984
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventor: Saul B. Kadin
  • Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • N-Benzyl-imidazoles as selective inhibitors of the thromboxane synthetase enzyme
    Patent number: 4555516
    Abstract: The N-(substituted benzyl) imidazoles are selective enzyme inhibitors and thus are useful in the treatment of heart disease, circulatory and vascular problems.
    Type: Grant
    Filed: January 9, 1980
    Date of Patent: November 26, 1985
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson
  • Antifungal 1-triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-2-ol derivatives
    Patent number: 4554286
    Abstract: 1-Triazolyl-2-aryl-3-(5-trifluoromethylimidazol-1-yl)propan-2-ol derivatives useful in the treatment of fungal infections in humans, animals and plants, and their preparation.
    Type: Grant
    Filed: May 3, 1984
    Date of Patent: November 19, 1985
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Peter J. Whittle
  • 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
    Patent number: 4554276
    Abstract: Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted amino derivatives thereof useful as inhibitors of leukotriene synthesis for the treatment of pulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In addition these compounds are cytoprotective and therefore useful in the treatment of peptic ulcers. A process for the preparation of such active compounds by ring rearrangement of 2-amino-5-acetyloxazole, pharmaceutical compositions containing the novel active compounds and compositions containing these compounds in combination with other anti-inflammatory agents or gastric anti-secretory agents.
    Type: Grant
    Filed: October 3, 1983
    Date of Patent: November 19, 1985
    Assignee: Pfizer Inc.
    Inventor: John L. LaMattina
  • Process for producing an acidic polycyclic ether antibiotic by cultivation of a novel strain of Streptomyces endus subspecies aureus
    Patent number: 4552843
    Abstract: A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
    Type: Grant
    Filed: February 17, 1984
    Date of Patent: November 12, 1985
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
    Patent number: 4551468
    Abstract: Heterocyclic thromboxane synthetase inhibitors of the formula ##STR1## wherein R.sup.1, which is attached to the 2-, 3- or 4-position, is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, hydroxy or C.sub.1 -C.sub.4 alkoxy;Y, which is attached to the 2- or 3-position, is --COOH, --COO(C.sub.1 -C.sub.4 alkyl) or --CONH.sub.2 ;X is O, S, NH, N(C.sub.1 -C.sub.4 alkyl) or N(benzyl); andR, which is attached to the 5-, 6- or 7-position, is a group of the formula ##STR2## or (3- or 4-pyridyl)--Z.sup.2 -- wherein Z.sup.1 is --CH.sub.2 --, --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 O-- and Z.sup.2 is --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 O-- or --OCH.sub.2 --;and their pharmaceutically acceptable salts; processes for their preparation, and pharmaceutical compositions containing them which are useful, for example, in the treatment of thrombosis.
    Type: Grant
    Filed: August 22, 1983
    Date of Patent: November 5, 1985
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson, Geoffrey N. Thomas
  • Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
    Patent number: 4551542
    Abstract: 6-Fluoro-4-chromanone can be regenerated from (R)-6-fluoro-4-ureidochroman-4-carboxylic acid, or from mixtures of (R)-6-fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification, by oxidation with a permanganate, especially potassium permanganate. 6-Fluoro-4-chromanone is a chemical intermediate useful for preparing sorbinil, an aldose reductase inhibitor which can be used in clinical medicine for the control of the chronic complications of diabetes. (R)-6-Fluoro-4-ureidochroman-4-carboxylic acid and its racemic modification are by-products from the production of sorbinil from 6-fluoro-4-chromanone.
    Type: Grant
    Filed: September 26, 1984
    Date of Patent: November 5, 1985
    Assignee: Pfizer Inc.
    Inventor: Bernard S. Moore
  • Flush edge protected metal laminates
    Patent number: 4551219
    Abstract: A process for producing a flush edge protected laminate of an inner sheet of a corrodable metal sandwiched between outer sheets of a protective metal which comprises attaching a C-shaped channel of the protective metal over the edge to be protected and rolling the laminate with the attached channel so that the channel is deformed to form a protective edge whose overlapping sides are flush with the upper and lower surfaces of the laminate; and a protected edge bi-metallic laminate prepared by the process.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: November 5, 1985
    Assignee: Pfizer Inc.
    Inventors: Gary D. Flick, John H. Reinshagen