Patents Assigned to Pfizer Limited
  • Publication number: 20220380307
    Abstract: Methods for providing a carboxamide compound and intermediates used in the preparation of the carboxamide compound are provided. The methods include reacting 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile benzoate with a reagent and hydrochloric acid to form the carboxamide compound including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide hydrochloride.
    Type: Application
    Filed: June 24, 2020
    Publication date: December 1, 2022
    Applicants: MYLAN LABORATORIES LIMITED, PFIZER LIMITED
    Inventors: Vadali Lakshmana Rao, Saidugari Swamy, Nagaraju Mittapelly, Dasari Srinivasa Rao, Sarah Haycock Lewandowski, Alan Pettman
  • Publication number: 20220370738
    Abstract: A filling head (20) for filling a container (22) includes a receptacle (24). The receptacle (24) includes an interior surface (26) configured to receive a powder (28) and having a plurality of openings (34) disposed therein to allow passage of the powder (28); and an exterior surface (52). The exterior surface (52) of the receptacle (24) has a plurality of raised surfaces (54), each of the plurality of raised surfaces having a plurality of openings (56) aligned with at least one of the plurality of openings (34) of the interior surface (26) to allow passage of the powder (28) from the receptacle (24) to the container (22). Methods of filling a container (22) are also provided.
    Type: Application
    Filed: June 24, 2020
    Publication date: November 24, 2022
    Applicants: MILAN PHARMA UK LIMITED, PFIZER LIMITED
    Inventors: Simon Cooper, Bruce MacMichael, Peter Houzego
  • Patent number: 11116917
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Grant
    Filed: November 7, 2018
    Date of Patent: September 14, 2021
    Assignee: PFIZER LIMITED
    Inventors: Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Patent number: 10538523
    Abstract: The present invention relates to pyrazolopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined in the description. The pyrazolopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They may useful in the treatment of a number of conditions, including pain and epilepsy.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: January 21, 2020
    Assignee: PFIZER LIMITED
    Inventors: Kevin Neil Dack, Robert McKenzie Owen, David Cameron Pryde
  • Patent number: 10370402
    Abstract: The invention relates to a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronization. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallize out of the solution as crystalline form.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: August 6, 2019
    Assignee: Pfizer Limited
    Inventors: Martyn David Ticehurst, Ivan Marziano, Eleftherios Kougoulos
  • Publication number: 20180346470
    Abstract: The present invention relates to pyrazolopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined in the description. The pyrazolopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They may useful in the treatment of a number of conditions, including pain and epilepsy.
    Type: Application
    Filed: November 22, 2016
    Publication date: December 6, 2018
    Applicant: PFIZER LIMITED
    Inventors: KEVIN NEIL DACK, ROBERT MCKENZIE OWEN, DAVID CAMERON PRYDE
  • Patent number: 10124130
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: November 13, 2018
    Assignee: Pfizer Limited
    Inventors: Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Patent number: 9802945
    Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: October 31, 2017
    Assignee: Pfizer Limited
    Inventors: Robert McKenzie Owen, David Cameron Pryde, Mifune Takeuchi, Christine Anne Louise Watson
  • Publication number: 20170305857
    Abstract: The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.
    Type: Application
    Filed: December 8, 2014
    Publication date: October 26, 2017
    Applicant: Pfizer Limited
    Inventors: SARAH ELIZABETH SKERRATT, SHARANJEET KAUR BAGAL, NIGEL ALAN SWAIN, KIYOYUKI OMOTO, MARK DAVID ANDREWS
  • Publication number: 20170281586
    Abstract: The present invention relates to solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 5, 2017
    Applicant: Pfizer Limited
    Inventors: Roland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
  • Publication number: 20170197965
    Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor.
    Type: Application
    Filed: June 3, 2015
    Publication date: July 13, 2017
    Applicant: Pfizer Limited
    Inventors: Robert McKenzie OWEN, David Cameron PRYDE, Mifune TAKEUCHI, Christine Anne Louise WATSON
  • Patent number: 9668998
    Abstract: The present invention relates to a solid molecular dispersion of from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate and a polymeric binder selected from the group consisting of an alkyl hydroxyalkylcellulose ether, a hydroxyalkylcellulose ether, an ester of either thereof, and a mixture of any two or more thereof.
    Type: Grant
    Filed: January 17, 2012
    Date of Patent: June 6, 2017
    Assignee: Pfizer Limited
    Inventors: Roland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
  • Patent number: 9561336
    Abstract: Various embodiments relate to a dose unit for a dry powder inhaler including: a dose carrier including a plurality of pockets each adapted to contain a dose of medication powder suitable for inhalation, the pockets being sequentially arranged such that the content of the pockets can be sequentially exposed to a flow of air for successive inhalations and a plurality of medication powder doses arranged in the pockets of the dose carrier. The doses are regularly distributed in the pockets according to a sequence of identical groups, each group including at least one blank pocket and one pocket containing a dose of medication powder. Various embodiments also relate to a pack including one such dose unit and one further dose unit with all pockets containing a medication powder. Various embodiments further relate to a dry powder inhaler including such a pack of dose units.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: February 7, 2017
    Assignee: PFIZER LIMITED
    Inventor: Ian Smith
  • Patent number: 9399103
    Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: July 26, 2016
    Assignee: PFIZER LIMITED
    Inventors: Peter John Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
  • Patent number: D776261
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: January 10, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson
  • Patent number: D785784
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: May 2, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson
  • Patent number: D786423
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: May 9, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson
  • Patent number: D790687
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: June 27, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson
  • Patent number: D792578
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: July 18, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson
  • Patent number: D802750
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: November 14, 2017
    Assignee: Pfizer Limited
    Inventors: Dawn Jones, David Pearce, Simon Wilson