Abstract: Methods for providing a carboxamide compound and intermediates used in the preparation of the carboxamide compound are provided. The methods include reacting 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanenitrile benzoate with a reagent and hydrochloric acid to form the carboxamide compound including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide hydrochloride.
Abstract: A filling head (20) for filling a container (22) includes a receptacle (24). The receptacle (24) includes an interior surface (26) configured to receive a powder (28) and having a plurality of openings (34) disposed therein to allow passage of the powder (28); and an exterior surface (52). The exterior surface (52) of the receptacle (24) has a plurality of raised surfaces (54), each of the plurality of raised surfaces having a plurality of openings (56) aligned with at least one of the plurality of openings (34) of the interior surface (26) to allow passage of the powder (28) from the receptacle (24) to the container (22). Methods of filling a container (22) are also provided.
Type:
Application
Filed:
June 24, 2020
Publication date:
November 24, 2022
Applicants:
MILAN PHARMA UK LIMITED, PFIZER LIMITED
Inventors:
Simon Cooper, Bruce MacMichael, Peter Houzego
Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
Type:
Grant
Filed:
November 7, 2018
Date of Patent:
September 14, 2021
Assignee:
PFIZER LIMITED
Inventors:
Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
Abstract: The present invention relates to pyrazolopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined in the description. The pyrazolopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They may useful in the treatment of a number of conditions, including pain and epilepsy.
Type:
Grant
Filed:
November 22, 2016
Date of Patent:
January 21, 2020
Assignee:
PFIZER LIMITED
Inventors:
Kevin Neil Dack, Robert McKenzie Owen, David Cameron Pryde
Abstract: The invention relates to a novel crystallization process for preparing fluticasone propionate as crystalline form 1 polymorph with controlled particle size and suitable for micronization. Said process comprises the step of dissolving fluticasone propionate in acetone or in a mixture of acetone and water and then adding this solution to water or to a mixture of water 10 and acetone, thereby causing fluticasone propionate to crystallize out of the solution as crystalline form.
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
August 6, 2019
Assignee:
Pfizer Limited
Inventors:
Martyn David Ticehurst, Ivan Marziano, Eleftherios Kougoulos
Abstract: The present invention relates to pyrazolopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-1H-pyrazolo[3,4-c]pyridazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4 and R5 are as defined in the description. The pyrazolopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They may useful in the treatment of a number of conditions, including pain and epilepsy.
Type:
Application
Filed:
November 22, 2016
Publication date:
December 6, 2018
Applicant:
PFIZER LIMITED
Inventors:
KEVIN NEIL DACK, ROBERT MCKENZIE OWEN, DAVID CAMERON PRYDE
Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
Type:
Grant
Filed:
June 13, 2016
Date of Patent:
November 13, 2018
Assignee:
Pfizer Limited
Inventors:
Peter J. Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant
Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
Type:
Grant
Filed:
June 3, 2015
Date of Patent:
October 31, 2017
Assignee:
Pfizer Limited
Inventors:
Robert McKenzie Owen, David Cameron Pryde, Mifune Takeuchi, Christine Anne Louise Watson
Abstract: The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.
Type:
Application
Filed:
December 8, 2014
Publication date:
October 26, 2017
Applicant:
Pfizer Limited
Inventors:
SARAH ELIZABETH SKERRATT, SHARANJEET KAUR BAGAL, NIGEL ALAN SWAIN, KIYOYUKI OMOTO, MARK DAVID ANDREWS
Abstract: The present invention relates to solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles.
Type:
Application
Filed:
April 12, 2017
Publication date:
October 5, 2017
Applicant:
Pfizer Limited
Inventors:
Roland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor.
Type:
Application
Filed:
June 3, 2015
Publication date:
July 13, 2017
Applicant:
Pfizer Limited
Inventors:
Robert McKenzie OWEN, David Cameron PRYDE, Mifune TAKEUCHI, Christine Anne Louise WATSON
Abstract: The present invention relates to a solid molecular dispersion of from 3:97 to 12:88 weight % ratio of fesoterodine hydrogen fumarate and a polymeric binder selected from the group consisting of an alkyl hydroxyalkylcellulose ether, a hydroxyalkylcellulose ether, an ester of either thereof, and a mixture of any two or more thereof.
Type:
Grant
Filed:
January 17, 2012
Date of Patent:
June 6, 2017
Assignee:
Pfizer Limited
Inventors:
Roland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
Abstract: Various embodiments relate to a dose unit for a dry powder inhaler including: a dose carrier including a plurality of pockets each adapted to contain a dose of medication powder suitable for inhalation, the pockets being sequentially arranged such that the content of the pockets can be sequentially exposed to a flow of air for successive inhalations and a plurality of medication powder doses arranged in the pockets of the dose carrier. The doses are regularly distributed in the pockets according to a sequence of identical groups, each group including at least one blank pocket and one pocket containing a dose of medication powder. Various embodiments also relate to a pack including one such dose unit and one further dose unit with all pockets containing a medication powder. Various embodiments further relate to a dry powder inhaler including such a pack of dose units.
Abstract: A device for dispensing individual doses of powder from respective pockets of a disc-shaped carrier by outwardly rupturing a lidding foil by means of pressure on an opposite side surface, the device providing individual respective deaggregation flow paths for each pocket, split airstreams allowing improved entrainment of powder, a cam mechanism for outwardly rupturing the pockets, an indexing mechanism linked to the cam mechanism and a dose counter.
Type:
Grant
Filed:
August 18, 2014
Date of Patent:
July 26, 2016
Assignee:
PFIZER LIMITED
Inventors:
Peter John Houzego, John Kelshaw Conway, Martin Douglas Pearl, Andrew Mark Bryant