Abstract: A batch process for carrying out a hydrogenation reaction comprises mixing a pyrophoric catalyst with reactants and solvents to form a reaction mixture in a reaction vessel. Hydrogen is added to the reaction vessel. After hydrogenation, the desired hydrogenation product is removed from the reaction vessel and the pyrophoric catalyst-rich material from the reaction vessel is delivered to a pressure filter. Water is added to the pyrophoric catalyst-rich material in the filter and the spent pyrophoric material is removed from the pressure filter in a water wet form.
Type:
Grant
Filed:
June 2, 2003
Date of Patent:
November 9, 2004
Assignee:
Pfizer Science and Technology Ireland Limited
Abstract: A factory scale process for producing crystalline atorvastatin calcium includes the step of drying the isolated product in a vacuum pan dryer. The vacuum pan dryer has an agitator which is continuously rotated at a speed of approximately 1 rpm. High quality material is routinely and consistently produced with reduced cycle time.
Type:
Grant
Filed:
August 8, 2003
Date of Patent:
May 4, 2004
Assignee:
Pfizer Science and Technology Ireland Limited
Inventors:
John O'Connell, William Tully, Evelyn Madigan
Abstract: An improved process for removing trace solvent from a material comprises rewetting the product with water during the drying process. Finished products such as suramin are produced efficiently to a high quality on a factory scale.
Type:
Grant
Filed:
June 14, 2002
Date of Patent:
February 3, 2004
Assignee:
Pfizer Science and Technology Ireland, Limited