Patents Assigned to Pfizer
  • Benzyl(Idene)-lactam derivatives, their preparation and their use as selective (ANT) agonists of 5-HT1A- and/or 5-HT1D receptors
    Patent number: 6924289
    Abstract: The present invention relates to lactam derivatives of the formula wherein R1, R2, R3, A, X, Z, n and the dashed line are defined herein, and pharmaceutical compositions thereof, to processes and intermediates for their preparation, and to their medicinal use as selective agonists and antagonists of serotonin 1 (5-HT1) receptors, specifically, of one or both of the 5-HT1A and 5-HT1D receptors. These compounds are useful in treating or preventing migraine, depression and other disorders for which a 5-HT1 agonist or antagonist is indicated.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: August 2, 2005
    Assignee: Pfizer Inc
    Inventor: Harry R. Howard
  • Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6924313
    Abstract: The invention relates to substituted tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid trans: protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery disease.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: August 2, 2005
    Assignee: Pfizer Inc.
    Inventors: James A. Sikorski, Richard C. Durley, Melvin L. Rueppel, Deborah A. Mischke, Barry L. Parnas
  • Dipeptide derivatives
    Patent number: 6924280
    Abstract: This invention is directed to compounds of the formula and the pharmaceutically-acceptable salts thereof, where the substituents are as defined in the Specification, which are growth hormone secretogogues and which increase the level of endogenous growth hormone. The compounds of this invention are useful for the treatment and prevention of osteoporosis and/or frailty, congestive heart failure, frailty associated with aging, obesity; accelerating bone fracture repair, attenuating protein catabolic response after a major operation, reducing cachexia and protein loss due to chronic illness, accelerating wound healing, or accelerating the recovery of burn patients or patients having undergone major surgery; improving muscle strength, mobility, maintenance of skin thickness, metabolic homeostasis or renal homeostasis.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: August 2, 2005
    Assignee: Pfizer Inc.
    Inventors: Philip Albert Carpino, David Andrew Griffith, Bruce Allen Lefker
  • 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides as antiviral agents
    Patent number: 6924283
    Abstract: The invention provides a compound of formula I: wherein R1, R2, R3, and R4 have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection, atherosclerosis or restenosis using such compounds or salts.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: August 2, 2005
    Assignee: Pfizer
    Inventor: Atli Thorarensen
  • Malonamic acids and derivatives thereof as thyroid receptor ligands
    Patent number: 6924310
    Abstract: The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias, skin disorders, thyroid disease, hypothyroidism, thyroid cancer and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, congestive heart failure, hypercholesteremia, depression, osteoporosis and hair loss. The present invention also provides methods, pharmaceutical compositions and kits for treating such diseases and disorders.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: August 2, 2005
    Assignees: Pfizer Inc., Pfizer Products Inc.
    Inventors: Yuan-Ching P. Chiang, Gary E. Aspnes, Kimberly G. Estep
  • Novel process
    Publication number: 20050165229
    Abstract: There is provided a process for the preparation of a compound according to Formula (II): which includes the step of cyclising a compound of Formula (III): wherein R1, R2, R3, R4, X and m have meanings which are given in the description.
    Type: Application
    Filed: November 22, 2004
    Publication date: July 28, 2005
    Applicant: Pfizer, Inc.
    Inventors: Desmond Best, George Burton, Brian Gasson, Neal Osborne, Graham Walker
  • Purine derivatives
    Patent number: 6921753
    Abstract: The present invention relates to compounds of the formula and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such compounds and the uses of such compounds as adenosine A2a receptor agonists.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: July 26, 2005
    Assignee: Pfizer Inc
    Inventors: Simon John Mantell, Sandra Marina Monaghan, Peter Thomas Stephenson
  • Aralkyl and aralkylidene heterocyclic lactams and imides
    Patent number: 6921760
    Abstract: The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. These compounds are useful as psychotherapeutic agents.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: July 26, 2005
    Assignee: Pfizer Inc.
    Inventor: Harry Ralph Howard
  • Thieno-pyrimidin-4-one AMPA antagonists
    Patent number: 6921764
    Abstract: The present invention relates to novel quinazolin-4-one derivatives of the formula I, as defined in the specification, pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol induced central and peripheral nervous system disorders.
    Type: Grant
    Filed: August 13, 2003
    Date of Patent: July 26, 2005
    Assignee: Pfizer Inc.
    Inventors: Bertrand L Chenard, Willard M Welch, Anthony R. Reinhold
  • Processes and intermediates useful in preparing ?3-adrenergic receptor agonists
    Patent number: 6919460
    Abstract: The present invention provides processes useful in the preparation of certain ?3-adrenergic receptor agonists of the structural formula the pharmaceutically acceptable salts thereof, and the hydrates of said pharmaceutically acceptable salts, wherein HET is as described herein. The invention further provides intermediates useful in the preparation of such agonists, and processes useful in the production of such intermediates.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: July 19, 2005
    Assignee: Pfizer Inc,
    Inventors: Robert J. Chambers, Robert W. Dugger, Ming Kang, Yong Tao, John W. Wong
  • N-substituted-heteroaryloxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors
    Patent number: 6919332
    Abstract: The present invention relates to N-substituted-heteroaryloxy-aryloxy-2,4,6-trione metalloproteinase inhibitors of the formula wherein X, A, Y, B, G, and R1 are as defined in the specification, and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: July 19, 2005
    Assignee: Pfizer Inc.
    Inventors: Mark C. Noe, Lilli Ann Wolf-Gouveia
  • Azabicyclic-substituted-heteroaryl compounds for the treatment of disease
    Patent number: 6919359
    Abstract: The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(?X)—W??Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Formula I are useful in pharmaceuticals in which ?7 is known to be involved.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: July 19, 2005
    Assignee: Pfizer Inc
    Inventors: David W. Piotrowski, Jason K. Myers, Bruce N. Rogers, Eric Jon Jacobsen, Alice L. Bodnar, Vincent E. Groppi, Jr., Daniel Patrick Walker, Brad A. Acker
  • 3-(imidazolyl)-2-aminopropanoic acids
    Patent number: 6919457
    Abstract: Compounds according to formula (I) wherein n is 1-4, R1 is optionally substituted C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl, Heterocycle, Aromatic heterocycle, Aryl or hydrogen and R2, R3, R4, R5, R6, R7 and R8 are each independently selected from hydrogen and optionally substituted C1-6 alkyl are novel. They are useful in the treatment of thrombotic conditions and other pathologies associated with fibrin deposition.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 19, 2005
    Assignee: Pfizer, Inc.
    Inventors: Charlotte Moira Norfor Allerton, Mark Edward Bunnage, John Steele
  • Triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
    Patent number: 6916807
    Abstract: The present invention relates to triaryl-oxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, G, and W are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: July 12, 2005
    Assignee: Pfizer Inc.
    Inventors: Kevin D. Freeman-Cook, Mark C. Noe
  • Attenuated forms of bovine viral diarrhea virus
    Patent number: 6916477
    Abstract: The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Npro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: July 12, 2005
    Assignee: Pfizer Inc.
    Inventors: Xuemei Cao, Michael G. Sheppard
  • Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent
    Patent number: 6916800
    Abstract: The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: July 12, 2005
    Assignee: Pfizer Inc
    Inventors: John P. McKearn, Gary Gordon, James J. Cunningham, Stephen T. Gately, Alane T. Koki, Jaime L. Masferrer
  • Oxytocin inhibitors
    Patent number: 6914160
    Abstract: This invention relates to compounds of formula (I)
    Type: Grant
    Filed: July 31, 2003
    Date of Patent: July 5, 2005
    Assignee: Pfizer Inc
    Inventors: Duncan Robert Armour, Andrew Simon Bell, Paul John Edwards, David Ellis, David Hepworth, Mark Llewellyn Lewis, Christopher Ronald Smith
  • Acylation process
    Patent number: 6914145
    Abstract: The present invention is concerned with the acylation of indoles, specifically the preparation of 3-acylated indoles which may be further treated to provide indoles having an alternative substituent at the 3-position.
    Type: Grant
    Filed: July 17, 2002
    Date of Patent: July 5, 2005
    Assignee: Pfizer, Inc.
    Inventor: Jolyon Francis Perkins
  • Human phosphodiesterase IV isozymes
    Patent number: 6914133
    Abstract: This invention relates to novel nucleic acid sequences encoding three novel human phosphodiesterase (hPDE IV) isozymes. It also relates to polypeptides encoded by such sequences. This invention also relates to an assay method for detecting the presence of such novel isozymes in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozymes.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: July 5, 2005
    Assignee: Pfizer Inc.
    Inventors: Douglas A. Fisher, Michael D. Robbins
  • Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
    Patent number: 6911544
    Abstract: The present invention is directed to a process for preparing (S,S)-cis-2-phenyl-3-aminopiperidine and (S,S)-cis-2-phenyl-3-tertbutoxycarbonylaminopiperidine.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: June 28, 2005
    Assignees: Pfizer Inc., DSM Pharmaceuticals, Inc.
    Inventors: Robert Seemayer, Thomas C. Nugent, Jack Liang