Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and X are as defined below. Such compounds are useful as oncogene inhibitors and antitumor agents.

Abstract: The hemiphosphate hemihydrate salt of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole is the preferred salt of this antiulcer agent.

Abstract: Avermectins wherein one or both of the 3'- and 3"-positions of the oleandrose disaccharide moiety is substituted by an ethoxy rather than a methoxy group, process for their preparation; and their use as antiparasitic agents.

Abstract: Certain 1-substituted 4-(1,2-benzisoxazolyl)-piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.

Abstract: An animal premix having improved levels of flowability and dustiness. The premix comprises about 2% to about 10% Semduramicin or its pharmaceutically acceptable cationic salts thereof, about 0.5% to about 50% Semduramicin degradation reducing stabilizer, about 40% to about 80% diluent, about 5% to about 50% density-increasing bulking agent, about 2% to about 10% dust controlling oil and about 0.25% to about 5% flowability enhancing glidant selected from the group consisting of sodium aluminosilicate and silicon dioxide. The invention is also directed to an animal feed containing the above described premix and a method of treating coccidial infections in an animal by administering that animal feed to an animal.

Abstract: Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein Q, X and R are as defined below. The compounds of formula I are broad spectrum mammalian antibacterial agents and exhibit favorable selectivity against procaryotic cells.

Abstract: Compounds of the formula ##STR1## wherein X is --CH.sub.2 --, --O-- or --S--, m is 1 to 3, n is 1 or 2 and R.sub.1 is hydrogen, C.sub.1 to C.sub.4 alkyl, aryl or aryl substituted with one or more substituents selected independently from the group consisting of halogen, nitro, cyano, C.sub.1 to C.sub.10 alkyl, C.sub.1 to C.sub.10 halosubstituted alkyl, C.sub.1 to C.sub.6 alkoxy, alkoxycarbonyl having from one to ten carbon atoms in the alkoxy moiety, aminocarbonyl, alkylaminocarbonyl having from one to ten carbon atoms in the alkyl moiety and dialkylaminocarbonyl having from one to ten carbon atoms in each of the alkyl moieties, and the pharmaceutically acceptable salts thereof, inhibit the enzyme lipoxygenase and are useful in treating allergy and inflammatory and cardiovascular conditions for which the action of lipoxygenase has been implicated. These compounds form the active ingredient in pharmaceutical compositions for treating such conditions.

Abstract: Compounds of the formula ##STR1## and pharmaceutical compositions comprising them, wherein R.sup.1, R.sup.2, R.sup.3, W, X and Z are as defined below. The compounds are inhibitors of 5-lipoxygenase enzyme and antagonists of leukotriene B4, leukotriene C4, leukotriene D4 and leukotriene E4.

Abstract: A method for preparing a compound of the formula ##STR1## wherein Q is C--H or N; R.sup.1 is C.sub.1-C.sub.4 alkyl, benzyl or p-nitrobenzyl and X and Y are independently selected from fluoro and chloro comprising reacting a compound of the formula ##STR2## wherein Q is >C--H or N; X and Y are independently selected from fluoro and chloro; and Z is fluoro, chloro, 1-imidazolyl or substituted 1-imidazolyl, wherein the 1-imidazolyl group is substituted with one or two substituents independently selected from C.sub.1 to C.sub.4 alkyl, with a compound of the formula[M.sup.n+ ].sub.p [V.sup.p- ].sub.nwherein M is an alkaline earth metal, Cu or Mn, n is 2, V.sup.p-, wherein p is 1 or 2, is an anion of the formula ##STR3## or a dianion of the formula ##STR4## and R.sup.1 is C.sub.1 to C.sub.6 alkyl or paranitrobenzyl, with the proviso that when Z is 1-imidazolyl or substituted 1-imidazole, M is magnesium, copper or manganese and with the proviso that when Z is fluoro, chloro or bromo, V.sup.

Abstract: A device for providing access to a living body. The device, in one embodiment, includes a slotted needle dimensioned and configured to receive, in fluid tight engagement, a catheter or a guidewire introduced into the needle through the slot. The device, in another embodiment, includes a sharpened, slotted first tube, a second tube piercable by the first tube for receipt therein of at least a potion of both the first tube and the slot, and an elongated element passing into the second tube, through the slot and into the first tube. The device might further include a third tube slidably positioned around the second tube.

Abstract: The present invention relates to novel 1-azabicyclo[3.2.2]nonan-3-amine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 are each independently selected from hydrogen, fluorine, chlorine, bromine, trifluoromethyl, alkyl having from one to three carbon atoms, alkoxy having from one to three carbon atoms, carboxy, alkoxycarbonyl having from one to three carbon atoms in the alkoxy moiety, and benzoyloxycarbonyl. These compounds are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.

Abstract: 1S,4S and 1R,4R-2-Alkyl-2,5-diazabicyclo[2.2.1]heptanes useful as intermediates in the synthesis of certain antibacterial quinolones, are prepared respectively, from trans-4-hydroxy-L-proline and trans-4-hydroxy-D-proline via multistep procedures.

Abstract: A process and intermediates for the manufacture of S-3-methylheptanoic acid from S-citronellol; a novel crystalline form of immunoregulatory N-(S-3-methlylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, an immunoregulatory agent; and an improved process and intermediates therefor.

Abstract: Heteropolysaccharide 105-4, prepared by fermentation of a new unnamed Pseudomonas species ATCC 53923 is useful as an industrial thickening, suspending or stabilizing agent.

Abstract: An automatic motorless label applying system includes a supply reel having a continuous carrier strip with a plurality of labels detachably mounted thereon. The strip is directed through an air actuated linear indexing mechanism which includes an upstream solenoid and a downstream solenoid. The upstream solenoid has clamp members which clamp the strip and then move it in a down-stream direction by the upstream solenoid itself moving laterally. The downstream solenoid clamps the strip when the upstream solenoid returns towards its original position. The labels are sequentially detached from the strip and each label is applied to a respective container.

Abstract: An automatic filling system which inserts objects into containers includes a feed hopper. A conveyor conveys a plurality of the objects into the feed hopper. The feed hopper has a discharge station. A collection station is located at the discharge station for disposing the containers in a position for receiving the objects fed from the discharge station. The feed hopper includes a flat inclined disc which receives the objects from the conveyor. The disc is rotated at a sufficiently high speed to cause the objects to move under centrifugal force toward the periphery of the disc. The feed hopper further includes a cylindrical member having an annular wall disposed around the disc and having an upper edge located generally at the same elevation as the upper end of the disc so that objects moving toward the periphery of the disc are moved to the upper edge of the cylindrical member and are conveyed on the upper edge away from the upper end of the disc.

Abstract: A modular femoral internal implant system for use in the treatment of femoral disorders resulting from injury, disease or congenital defect includes at least three interconnectable components: 1) an elongated epiphyseal/metaphyseal implant, 2) an intramedullary rod and 3) an angled side plate having an elongated plate portion adapted to be secured to the outer cortical wall and a hollow sleeve adapted to extend into the femur. The epiphyseal/metaphyseal implant can be connected to either the angled side plate or the intramedullary rod. The system may also include an elongated bone plate connectable to the angled side plate, one or more additional epiphyseal/metaphyseal implants of variable length, an additional angled side plate, a distal buttress plate connectable to the elongated bone plate, and a plurality of bone screws of a universal design. Preferably, many or all of the components of the system are made of an inert, resilient titanium-base alloy.

Abstract: An automatic blister system includes an inspection station into which blisters are delivered in seriatim. After inspection the blisters are removed from the inspection station. A transport assembly conveys the blister through the inspection station. A sensor or detector is mounted in the inspection station directed at the path of travel of the blisters. In addition, a high speed camera is in the inspection station which is actuated by the sensor for capturing a picture of the blister. The characteristics of the blister in the picture are then monitored.

Abstract: The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, whereinR is phenyl optionally substituted by 1 to 3substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).