Abstract: The bone prosthesis of the present invention comprises a first body member or stem for placement into a bone cavity, such as an intramedullary canal. The body member is configured and dimensioned so as to provide a nonuniform interference press-fit. The apparatus further comprises a second body member or broach for placement into and removal from a bone cavity, the broach configured and dimensioned so as to prepare the bone cavity so as to provide a nonuniform interference press-fit with the stem. The apparatus further comprises a distal sleeve configured and dimensioned so as to be attached to the stem so as to centralize the stem in the bone cavity. The distal sleeve preferably is provided with an interior conical slope and an exterior conical slope on a portion thereof to aid in insertion into the canal. The stem further comprises at least one groove and preferably a plurality of grooves along its corners.

Abstract: A method and apparatus for use in reducing the volatilization of the monomer component of bone cement is used after a prosthesis is implanted and throughout the polymerization of bone cement. The apparatus includes a generally annular inflatable sealing member having a centrally located opening therein for fitting over the exposed end of the prosthesis. The sealing member has an outer diameter covering the exposed surface of the bone cement. The sealing member has a deformable surface disposed in a substantially co-planar relationship with the exposed surface of the bone cement. The sealing member is resiliently expandable by inflation and extends beyond the edges of the bone defining the cavity, to seal the bone cavity upon the deformation of the deformable surface thereon. A pump is provided for inflating the sealing member and causing the deformable surface to apply pressure to the exposed surface of the bone cement.

Abstract: An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.

Abstract: Certain 1-substituted 4-(1,2-benzisoxazolyl)piperidine compounds exhibit neuroleptic activity and are useful in the treatment of psychosis and anxiety.

Abstract: Material, such as natural ground and precipitated calcium carbonate, when modified by surface-treatment with a cationic polymer, has been discovered to be highly effective as a filler material in the making of paper. Utilization of this type of filler material greatly improves the papermaking process by reducing the usage of wet end sizing agent, improving opacity, improving filler retention in the furnish, and causing better drainage on the papermachine, all of which result in the production of a high quality paper having excellent opacity and tensile strength characteristics. The nature of the polymer-modified filler material, the process for its preparation and the method of its use in papermaking are disclosed.

Abstract: Improved means for constraining a rumen drug delivery device in a rolled configuration, said means comprising a laminate, which may be perforated, comprising a water-permeable material having a low friction surface in the presence of water, said material being bonded by means of a water-dispersible pressure sensitive adhesive to a repulpable tape, said tape having said water-dispersible pressure sensitive adhesive on both its surfaces; a laminate comprising a flexible, water-permeable polymeric material bonded between the low friction surface material and the repulpable tape; and devices constrained by said means.

Abstract: Certain benzimidazole compounds and their pharmaceutically acceptable salts, are dual inhibitors of lipoxygenase and cycylooxygenase enzymes, and so are useful as antiallergy and antiinflammatory agents.

Abstract: There is disclosed a browning composition for uncooked foods comprising a colorant and a fat or an oil. Also disclosed is a process for imparting a brown color to cooked foods by using the composition of the present invention on foods cooked, for example, in a microwave oven.

Abstract: Azabicyclo[2.2.2]octan-3-imines of the general formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined herein are prepared by reacting a compound of the formula ##STR2## with a compound of the formula ##STR3## wherein A is MgCl, MgBr or Li.

Abstract: A process and intermediates for the manufacture of S-3-methylheptanoic acid from S-citronellol; a novel crystalline form of immunoregulatory N-(S-3-methylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine, an immunoregulatory agent; and an improved process and intermediates therefor.

Abstract: Immunoregulatory N-(S-3-alkyl-4-heptenoyl)- and N-(S-3-alkylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine and esters thereof are synthesized via R-trans-2-hexen-4-ols, R-3-alkyl-4-heptenoic acid and S-3-alkylheptanoic acid.

Abstract: Novel beta lactam compounds having potent elastrase inhibition activity are disclosed. These compounds are characterized by the general structural formulae I, II, and III: ##STR1## These compounds are further characterized such that X and Y are each --S-- or --CH.sub.2 --, with at least one of X and Y being --S--, or alternatively, X is --SO-- or --SO.sub.2 -- and Y is --CH.sub.2 --; R.sup.1 is hydrogen, tri(lower alkyl)silyl, --COOR" or --CONHR"', wherein R" and R"' are each lower alkyl or phenyl(lower alkyl), and may be the same or different; R.sup.3 is hydrogen, lower alkyl or (lower alkyl)oxy; one of B and D is (lower alkyl)oxycarbonyl, (lower alkenyl)oxycarbonyl, allyloxycarbonyl or phenyl(lower alkyl)oxycarbonyl; and the other of B and D is hydrogen or lower alkyl.The compounds are useful as anti-inflammatory agents, particularly in the treatment of adult respiratory distress syndrome and rheumatoid arthritis.

Abstract: Hypoglycemic thiazolidine-2,4-dione derivatives ##STR1## wherein the dotted line represents a bond or no bond;V is --CH.dbd.CH--, --N.dbd.CH--, --CH.dbd.N-- or S;W is CH.sub.2, CHOH, CO, C.dbd.NOR or --CH.dbd.CH--;X is S, O, NR.sup.1, --CH.dbd.N-- or --N.dbd.CH--;Y is CH or N;Z is hydrogen, (C.sub.1 -C.sub.7)alkyl, (C.sub.3 -C.sub.7) cycloalkyl, phenyl, naphthyl, pyridyl, furyl, thienyl or phenyl mono- or disubstituted with the same or different groups which are (C.sub.1 -C.sub.3)alkyl, trifluoromethyl, (C.sub.1 -C.sub.3)alkoxy, fluoro, chloro or bromo;Z.sup.1 is hydrogen or (C.sub.1 -C.sub.3)alkyl;R is hydrogen or methyl; andn is 1, 2 or 3;a pharmaceutically acceptble cationic salt thereof; or a pharmaceutically acceptable acid addition salt thereof when the compound contains a basic nitrogen.

Abstract: Novel 5-alkanesulphonamido-2-[N-(alkanesulphonamidoheterocyclicmethyl)-N-methyla mino]indane compounds have been prepared, including their pharmaceutically acceptable salts and various key novel intermediates therefor. The heterocyclic moiety present in these compounds is a benzofused heteroclyclic group derived from either benzofuran or quinoline, and it is attached to the adjacent methyl group of the molecule by means of the available ring carbon atom which is situated alpha to the hetero atom. These compounds are useful in therapy as anti-arrhythmic agents and therefore, are of value in the treatment of various cardiac arrhythmias. The most preferred member compound is 5-methanesulphonamido-2-[N-(5-methanesulphonamidobenzofur-2-ylmethyl)-N-me thylamino]indane. Methods for preparing these compounds from known starting materials are provided.

Abstract: A method of treating a chemical dependency in a mammal, comprising administering to a mammal in need of such treatment an amount of the compound (1S-cis)-4-(3, 4-dichlorophenyl)-1,2,3,4-tetraahydro-N-methyl-1-naphthalenamine, also known by the generic name sertraline, or a pharmaceutically acceptable salt thereof, effective in reducing or alleviating such dependency.

Abstract: Certain N-(substituted)-1-heteroaryl-oxindole-3-carboxamides wherein the N-substituent is thienyl, furyl, phenyl or substituted phenyl, are inhibitors of cycloxygenase and lipoxygenase enzymes and are useful as anti-inflammatory agents in mammals.

Abstract: Antidepressant agents having the formula ##STR1## wherein R.sup.1 is a polycycloalkyl group; R.sup.2 is methyl or ethyl, X is O; and Y comprises a 5-membered heterocyclic ring having one or two nitrogens.

Abstract: A process for the preparation of high purity calcium titanate hydrates, particularly various forms of kassite, is disclosed. Calcium carbonate and titanium tetraisopropoxide are used as starting materials. The process utilizes a hydrothermal reaction step. Hydrates having both hexagonal form, wherein the particles have a platy morphology, and lath form, wherein the particles have a rodlike morphology are produceable according to the process. Particle morphology is determined by the choice of process parameters, especially the rate of heating during the hydrothermal reaction step. Kassite particles of the hexagonal plate form, which are useful as a high opacity paper coating pigment, are produced when the rate of heating is less than or equal to 1.5.degree.C./min. Faster rates of heating result in kassite particles of a lath form. These particles are useful as a reinforcing material in polymers and ceramics.

Abstract: Combinations having synergistic anxiolytic activity which comprise a first component selected from the group consisting of 8-hydroxy-2-(dipropylamino)-tetralin, gepirone, ipsapirone, tandospirone, (7S,9S)-2-pyrimidyl)-7-(succinimidomethyl)-perhydro-1H-pyrido[1,2-a]pyrazi ne, or chlordiazepoxide; and a second component selected from the group consisting of 1-(2-pyrimidyl)pyrazine and idazoxan.

Abstract: This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This invention also relates to compositions comprising said polypeptides and salts thereof.