Abstract: A compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is amino, hydroxy, alkoxy, phenoxy or benzyloxy, useful in the treatment of hypertension, angina, renal impairment or acute renal failure.

Abstract: A new acidic polycyclic antibiotic UK-61,689 has the formula: ##STR1## or a pharmaceutically acceptable cationic salt thereof. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis and swine dysentery as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants.

Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is methyl, ethyl, n-propyl or isopropyl; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butylcarbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## where at least one of R.sup.3, R.sup.4, R.sup.5, R.sup.6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, X is O, S, SO, SO.sub.2, C.dbd.O or CHOH; m is zero or 1-4, n and p are each zero, 1, 2 or 3 where the sum of n+p is not greater than 3 and the sum of the carbon atoms in R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is not greater than six, and when both of R.sup.3 and R.sup.4 or R.sup.5 and R.sup.6 are alkyl they are methyl or ethyl, ##STR3## where one of R.sup.7, R.sup.8, R.sup.

Abstract: A device for the controlled release of a substance having useful activity into a fluid medium at a substantially constant rate, said substance contained in a shape which is substantially that of a truncated cone by means of an impermeable wall or coating on the base and side (but not the top) of said truncated cone. Apparatus useful in manufacture when said device is a tablet for administration to a mammal.

Abstract: Compounds of the formula: ##STR1## where R is 2-substituted phenyl said substituent being chloro, bromo, cyano, methyl, methylthio, methylsulfonyl, trifluoromethyl, hydroxy, methoxy or benzyloxy; R.sup.1 is hydrogen, lower alkyl, pyridyl, thiazolyl, isoxazolyl, thiadiazdyl or thiazdylmethyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydroxy, lower alkoxy, benzyloxy, amino, lower alkylamino or morpholino; Y is alkylene having two to six carbon atoms; and X is benzimidazolyl optionally substituted by lower alkyl, chloro or trifluoromethyl.

Abstract: An automatic gunning apparatus for repairing metallurgical furnaces includes a device for supplying refractory material to effect the repair; a detachably mounted gunning pipe fitted to the supply device; a pair of pinch rollers for moving the gunning pipe forward along its axis; a rotating drum through which the gunning pipe passes and which encloses the gunning pipe; a plurality of rollers for rotating the drum about its axis; a platform supporting the rollers; a column bearing the platform; a device for tilting the platform; and a support fixture for the pinch rollers rigidly connected to the drum such that the gunning pipe is axially rotated by the rotation of the drum.

Abstract: This invention relates of the use of a certain thiazolidine-2,4-dione, namely, dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]thiazolidine-2,4-dio ne, or a pharmaceutically acceptable cationic salt thereof, for retarding the development of arterial disease in mammals. More specifically, it relates to a method for reducing the serum cholesterol levels in mammals by administering to said mammals dl-5-[(2-benzyl-3,4-dihydro-2H-benzopyran-6-yl)methyl]-thiazolidine-2,4-di one or a pharmaceutically acceptable cationic salt thereof.

Abstract: 1-Phenylquinazoline-1H,3H-2,4-diones and 1-phenylpyrido-[2,3d]-pyrimidine-1H,3H-2,4-diones, their esters and acid addition salts, and pharmaceutical compositions containing such compounds have antidepressant, anti-inflammatory and analgesic activity.

Abstract: Antiarrhythmic agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R and R.sup.1, which are the same or different, are C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.7 cycloalkyl, --CH.sub.2 CH.sub.3, --CH.sub.2 Cl, --CF.sub.3 or --NH.sub.2 ;R.sup.2 and R.sup.3, which are the same or different, are H, halo, CF.sub.3, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy; andX is --CH.sub.2 --, ##STR2## or --CH(OH)--.

Abstract: 6-(1-Carbamoyl-1-hydroxymethyl)penicillanic acid derivatives are useful as antibacterials and/or beta-lactamase inhibitors.

Abstract: Certain trans-3-[3-(3-hydroxy-2-piperidyl)-2-oxopropyl]thieno[3,2-d]pyrimidin-4(3H )-one and furo[3,2-d]pyrimidin-4(3H)-one derivatives, a method of using same as anticoccidial agents, intermediates therefor, and a process for certain intermediates therefor.

Abstract: Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R.sup.a is methyl, hydroxymethyl, ethyl, n-propyl or isopropyl; R is ##STR2## where at least one of R.sup.3, R.sup.4, R.sup.5, R.sup.6 is alkyl having from one to four carbon atoms and the remainder are hydrogen or alkyl having from one to four carbon atoms, and the sum of the carbon atoms in R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is not greater than six; and when both of R.sup.3 and R.sup.4 or R.sup.5 and R.sup.6 are alkyl, they are methyl or ethyl.Said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amine and amide intermediates useful in their production.

Abstract: 6-Fluoro-7-pyridylquinolone carboxylic esters and acids having antibacterial activity are prepared by coupling of a 2-fluorophenyl-metallic compound with a pyridyl bromide or iodide in the presence of a transition metal catalyst, nitrating and hydrogenating the pyridyl-2-fluorophenyl compound formed, introducing a substituent on the nitrogen of the amine formed, and cyclizing after reacting with a dialkyl or dibenzyl ethoxymethylene malonate to form a 6-fluoro-7-pyridyl-1,4-dihydroquinol-4-one 3-carboxylate, and hydrolyzing to the corresponding acid.

Abstract: Process and intermediates for the conversion of 3R,4R-4-acetoxy-3-[1R-1-(silyloxy)ethyl]-2-azetidinones to antibacterial 5R,6S-6-(1R-1-hydroxyethyl)-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids, and the pharmaceutically-acceptable salts and pivaloyloxymethyl esters thereof.

Abstract: A device for zero order releasing of biologically active substances into a fluid medium comprising a cylindrical tablet or bolus covered with an impermeable wall or coating from which strips of said wall or coating have been removed.

Abstract: 1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.

Abstract: Certain new 2-oxindole-3-carboxamide compounds having an acyl substituent at the 1-position are inhibitors of the cyclooxygenase (CO) and lipoxygenase (LO) enzymes, and are useful as analgesic and anti-inflammatory agents in mammalian subjects. In particular, the compounds of the invention are useful for acute administration for ameliorating or eliminating pain in human subjects recovering from surgery or trauma, and also for chronic administration for alleviating the symptoms of chronic diseases, such as rheumatoid arthritis and osteoarthritis, in human subjects.

Abstract: The present invention relates to certain compounds of the formula ##STR1## wherein the broken line is a bond or no bond, and the pharmaceutically acceptable cationic salts thereof having utility as hypoglycemic and anti-atherosclerosis agents, methods for their use and pharmaceutical compositions containing them.

Abstract: Certain 4-aryl-5-carbamoyl-1,4-dihydropyridines useful in the treatment of allergic and inflammatory conditions in mammals.

Abstract: A series of pyridyl or imidazolyl substituted phenyl piperazines having utility as anti-arrhythmic agents is disclosed.