Patents Assigned to Pfizer
  • 2-(2-quinazolinylaminoalkoxymethyl)-1,4-dihydropyridine derivatives as cardiovascular agents
    Patent number: 4647565
    Abstract: Dihydropyridines of the formulae ##STR1## wherein R is chlorothienyl or mono- or disubstituted phenyl where said substituent is fluoro, chloro, bromo or trifluoromethyl; R.sup.1 and R.sup.2 are each alykl; R.sup.3 and R.sup.4 when taken separately are each hydrogen or alkyl; R.sup.3 and R.sup.4 when taken together with the nitrogen to which they are attached are piperidine or pyrrolidine; R.sup.5 is alkyl or 2-hydroxyethyl; R.sup.6 is hydrogen or methoxy; X and Z are each hydrogen or methoxy; Y is alkylene; R.sup.7 is chlorophenyl or trifluoromethyl-chlorophenyl; p is 0 or 1; and Q is CH or N are useful in the treatment of hypertension, heart failure and angina.
    Type: Grant
    Filed: June 5, 1985
    Date of Patent: March 3, 1987
    Assignee: Pfizer Inc.
    Inventors: John E. Arrowsmith, Simon F. Campbell, Peter E. Cross, Roger P. Dickinson
  • Oxindole antiinflammatory agents
    Patent number: 4644005
    Abstract: Ketone containing 1-substituted oxindole-3-carboxamides as antiinflammatory agents prepared by reaction of the 1-substituted oxindole with an isocyanate or by aminolysis of the corresponding alkyl oxindole-3-carboxylate.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: February 17, 1987
    Assignee: Pfizer Inc.
    Inventor: Lawrence S. Melvin, Jr.
  • Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
    Patent number: 4642373
    Abstract: 1,2,3,4,4a,4b,5,6,7,8,8a,12b-Dodecahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy or alkoxyalkyl)triphenylenes, 2,3,3a,3b,4,5,6,7,7a,11b-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)-1H-cyclopenta[1]-phenanthrenes, 2,3,4,4a,4b,5,6,7,8,8a-decahydro-7-(oxo, hydroxy or amino)-9-hydroxy-11-(alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl)-1H-pyrido[1,2-f]phenanthridines, and 1,2,3,3a,3b,4,5,6,7,7a-decahydro-6-(oxo, hydroxy or amino)-8-hydroxy-10-(alkyl, alkoxy or alkoxyalkyl)pyrrolo[1,2-f]phenanthridines and derivatives are valuable as central nervous system active agents or as intermediates to compounds having such activity.
    Type: Grant
    Filed: July 6, 1984
    Date of Patent: February 10, 1987
    Assignee: Pfizer Inc.
    Inventors: James F. Eggler, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Biopolymer compositions having enhanced filterability
    Patent number: 4639322
    Abstract: Biopolymers comprising xanthomonas and methylene bis (thiocyanate) are disclosed.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: January 27, 1987
    Assignee: Pfizer Inc.
    Inventors: Donald Beck, James W. Miller, William C. Wernau, Thomas B. Young, III
  • Triazole antifungal agents
    Patent number: 4638007
    Abstract: Antifungal 1-[3-(substituted)-2-hydroxy-2-(perfluoroalkyl)-propyl]triazole derivatives wherein the 3-propyl substituent represents optionally substituted phenoxy, heteroaryloxy, alkylthio, alkylsulfinyl, alkylsulfonyl or optionally substituted carbamoyl.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: January 20, 1987
    Assignee: Pfizer Inc.
    Inventors: Kenneth Richardson, Peter J. Whittle
  • Formulation of antiinflammatory drugs
    Patent number: 4636498
    Abstract: An improved antiinflammatory composition and method of treating inflammation which employs a combination of an antiinflammatory agent (e.g. indomethacin or an oxicam) with a histamine-H.sub.2 antagonist selected from the group consisting of 2-guanidino-4-(4-imidazolyl)thiazole, 2-guanidino-4-(2-methyl-4-imidazolyl )thiazole, 2-(N-benzyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, 2-(N-pentyl-N'-guanidino)-4-(2-methyl-4-imidazolyl)thiazole and 2-guanidino-4-[2-(hexylamino)-4-imidazolyl]thiazole.
    Type: Grant
    Filed: August 15, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer Inc.
    Inventor: John L. LaMattina
  • 7-heterocyclic-1,4-dihydroquinolones
    Patent number: 4636506
    Abstract: 1-Alkyl-6,8-difluoro-7-heterocyclic-1,4-dihydroquinol-4-one 3-carboxylic acids having antibacterial activity are prepared by conventional cyclization methods.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer, Inc.
    Inventors: Paul J. Gilligan, Paul R. McGuirk, Michael J. Witty
  • N-(phenoxyalkyl)imidazoles as selective inhibitors of the thromboxane synthetase enzyme and pharmaceutical compositions thereof
    Patent number: 4636500
    Abstract: N-(mono or disubstituted Phenoxyalkyl)imidazoles and the pharmaceutically acceptable acid addition salts thereof are able to selectively inhibit the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus useful in the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis migraine and the vascular complications of diabetes.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: January 13, 1987
    Assignee: Pfizer Inc.
    Inventors: Peter E. Cross, Roger P. Dickinson
  • Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
    Patent number: 4632993
    Abstract: 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazole dihydrobromide and a one-pot, high yield process for its preparation from 2-methyl-4(or 5)-acetylimidazole.
    Type: Grant
    Filed: October 11, 1984
    Date of Patent: December 30, 1986
    Assignee: Pfizer Inc.
    Inventor: Berkeley W. Cue, Jr.
  • Intermediates for preparing pirbuterol and analogs
    Patent number: 4632992
    Abstract: Processes and intermediates useful in the preparation of bronchodilator compounds of the formula ##STR1## wherein R is hydrogen, methyl or hydroxymethyl are described. Those compounds wherein R is H or CH.sub.3 have been found to have further utility as intermediates for pirbuterol (wherein R is hydroxymethyl).
    Type: Grant
    Filed: August 16, 1984
    Date of Patent: December 30, 1986
    Assignee: Pfizer Inc.
    Inventors: Berkeley W. Cue, Stephen S. Massett
  • Thiazole precursors for the preparation of biotin
    Patent number: 4631345
    Abstract: A novel process is described for preparation of biotin comprising preparation of substituted 3H, 5H-imidazo[1, 5c]tetrahydro thiazoles by contacting the boron triflouride adduct of an appropriate thiazoline with the metallic derivative of an ester enolate, reducing the ester, hydrolyzing the thiazolidine moiety and hydrolyzing or oxidizing the resultant compound. Intermediates obtained in the preparation of biotin by the above process and alternate procedures for preparing said intermediates are also presented. A novel process for preparation of d-biotin is also given.
    Type: Grant
    Filed: February 18, 1986
    Date of Patent: December 23, 1986
    Assignee: Pfizer Inc.
    Inventor: Robert A. Volkmann
  • Cobalt-chromium superalloy
    Patent number: 4631082
    Abstract: An oxide dispersion strengthened cobalt-chromium superalloy produced by mechanical alloying containing a refractory oxide, preferably yttrium oxide, and characterized by excellent corrosion resistance, high fatigue strength and high temperature stability; and prostheses formed from said superalloy.
    Type: Grant
    Filed: February 20, 1985
    Date of Patent: December 23, 1986
    Assignee: Pfizer Hospital Products Group Inc.
    Inventors: Henry L. Andrews, Gregory E. Gardiner
  • Antibacterial 2-amino-oxazolinones and process therefor
    Patent number: 4629794
    Abstract: A series of novel antibacterially active derivatives of indolmycin as well as some prodrug forms of indolmycin is disclosed. A novel process for the production of these compounds is also disclosed.
    Type: Grant
    Filed: January 23, 1986
    Date of Patent: December 16, 1986
    Assignee: Pfizer Inc.
    Inventor: John P. Dirlam
  • Novel hybrid corn plant
    Patent number: 4629819
    Abstract: F.sub.1 hybrid corn plants DK 524, seeds produced by cultivation of the hybrid, and plant cells which upon growth and differentiation produce the novel hybrid.
    Type: Grant
    Filed: April 26, 1985
    Date of Patent: December 16, 1986
    Assignee: DeKalb-Pfizer Genetics
    Inventor: Marvin F. Lindsey
  • Novel host strain for transformation of Yarrowia lipolytica
    Patent number: 4628033
    Abstract: A Yarrowia lipolytia strain (PC-30827) ATCC 20688 which is utilized as a suitable host for cloning. The strain is a double auxotroph and requires medium supplemented with leucine and uracil for growth.
    Type: Grant
    Filed: October 6, 1983
    Date of Patent: December 9, 1986
    Assignee: Pfizer Inc.
    Inventor: John R. DeZeeuw
  • Calcium-aluminum briquettes
    Patent number: 4627961
    Abstract: Calcium-aluminum briquettes comprising a mechanically compressed mixture of 65 to 80% by weight of calcium granules and 20 to 35% by weight of aluminum granules are added to molten lead to obtain a lead alloy containing about 0.1% by weight of calcium and 0.03% by weight of aluminum.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: December 9, 1986
    Assignee: Pfizer Inc.
    Inventor: David M. Dudek
  • Iron deficiency chlorosis resistant soybean variety
    Patent number: 4626610
    Abstract: A soybean variety which is a high yielder and resistant to iron deficiency chlorosis.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: December 2, 1986
    Assignee: DeKalb-Pfizer Genetics
    Inventor: Paul Sun
  • Acidic polycyclic ether antibiotic
    Patent number: 4625041
    Abstract: A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: November 25, 1986
    Assignee: Pfizer Inc.
    Inventors: Walter D. Celmer, Walter P. Cullen, Hiroshi Maeda, Junsuke Tone
  • Caprolactone polymers for suture coating
    Patent number: 4624256
    Abstract: High molecular weight caprolactone polymers are coated on surgical sutures to improve suture properties such as smooth surface, single knot slipdown, two throw knot slipdown for repositioning, and three throw knot security.
    Type: Grant
    Filed: September 11, 1985
    Date of Patent: November 25, 1986
    Assignee: Pfizer Hospital Products Group, Inc.
    Inventors: Kenneth A. Messier, Joseph D. Rhum
  • Antiprotozoal 1,4-di(p-amidinophenyl)imidazoles
    Patent number: 4624958
    Abstract: Diamidines of the formula ##STR1## wherein X is a propylene, isobutylene, guanidine, pyrrole, tetrazole, imidazole or substituted imidazole group; and 2-[4-(2-imidazolinyl)phenyl]-6-(2-imidazolinyl)indole, are useful in the treatment of certain protozoal infections in mammals, particularly in cattle.
    Type: Grant
    Filed: August 28, 1985
    Date of Patent: November 25, 1986
    Assignee: Pfizer Inc.
    Inventor: Edward A. Glazer