Patents Assigned to Pfizer
  • INTERFERON BETA ANTIBODIES AND USES THEREOF
    Publication number: 20170313769
    Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFN?). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.
    Type: Application
    Filed: April 28, 2017
    Publication date: November 2, 2017
    Applicants: PFIZER INC., THE BRIGHAM AND WOMEN?S HOSPITAL, INC.
    Inventors: Stefano V. Gulla, Christine Huard, Janet Elizabeth Buhlmann, Juan Carlos Almagro, Sreekumar R. Kodangattil, Steven A. Greenberg, Edward Roland Lavallie, Eric M. Bennett, Lidia Mosyak, James Perry Hall, Anthony John Coyle
  • ENGINEERED POLYPEPTIDE CONJUGATES AND METHODS FOR MAKING THEREOF USING TRANSGLUTAMINASE
    Publication number: 20170313787
    Abstract: The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
    Type: Application
    Filed: May 11, 2017
    Publication date: November 2, 2017
    Applicants: PFIZER INC., RINAT NEUROSCIENCE CORP.
    Inventors: Pavel STROP, Magdalena Grazyna DORYWALSKA, Arvind RAJPAL, David SHELTON, Shu-Hui LIU, Jaume PONS, Russell DUSHIN
  • Immunogenic fusion polypeptides
    Patent number: 9802987
    Abstract: In one aspect, the invention relates to an isolated polypeptide including the amino acid sequence of a carrier polypeptide and the amino acid sequence of an ORF2086 polypeptide. In another aspect, the invention relates to an immunogenic conjugate including ORF2086 polypeptide and a carrier polypeptide. The invention further includes immunogenic compositions and methods for inducing an immune response against Neisseria meningitidis in a mammal.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: October 31, 2017
    Assignee: Pfizer Inc.
    Inventors: Deborah Ann Dilts, Annaliesa Sybil Anderson, Kathrin Ute Jansen, Justin Keith Moran, Mark E Ruppen, Eugene Joseph Vidunas
  • Imidazopyridazine derivatives as modulators of the GABAA receptor activity
    Patent number: 9802945
    Abstract: The present invention relates to imidazopyridazine derivatives. More particularly, it relates to 4-(biphenyl-3-yl)-7H-imidazo[4,5-c]pyridazine derivatives of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined in the description. The imidazopyridazine derivatives of the present invention modulate the activity of the GABAA receptor. They are useful in the treatment of a number of conditions, including pain.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: October 31, 2017
    Assignee: Pfizer Limited
    Inventors: Robert McKenzie Owen, David Cameron Pryde, Mifune Takeuchi, Christine Anne Louise Watson
  • Cover for housing a syringe, assembly comprising such cover, pen-injector comprising such assembly and method for forming a pen-injector
    Patent number: 9801995
    Abstract: The invention relates to a cover for housing a syringe, an assembly comprising such cover, a pen-injector comprising such assembly and a method for forming a pen-injector.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: October 31, 2017
    Assignee: Pfizer Health AB
    Inventors: Francesco DeRosa, Torbjorn Lindwall, Anna Sahlin
  • N-ACYLPIPERIDINE ETHER TROPOMYOSIN-RELATED KINASE INHIBITORS
    Publication number: 20170305857
    Abstract: The present invention relates to compounds of Formula (I) described herein and their pharmaceutically acceptable salts, and their use in medicine, in particular as Trk antagonists.
    Type: Application
    Filed: December 8, 2014
    Publication date: October 26, 2017
    Applicant: Pfizer Limited
    Inventors: SARAH ELIZABETH SKERRATT, SHARANJEET KAUR BAGAL, NIGEL ALAN SWAIN, KIYOYUKI OMOTO, MARK DAVID ANDREWS
  • 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,3-Thiazol-4-yl Amides
    Publication number: 20170304312
    Abstract: The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variable R1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: June 21, 2017
    Publication date: October 26, 2017
    Applicant: Pfizer Inc.
    Inventors: Michael Aaron Brodney, Elizabeth Mary Beck, Christopher Ryan Butler, Lei Zhang, Brian Thomas O'Neill, Gabriela Barreiro, Erik Alphie LaChapelle, Bruce Nelsen Rogers
  • N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES
    Publication number: 20170305931
    Abstract: The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1, R2 and R3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Application
    Filed: July 11, 2017
    Publication date: October 26, 2017
    Applicant: Pfizer Inc.
    Inventors: Michael Aaron Brodney, Christopher Ryan Butler, Lei Zhang, Brian Thomas O'Neill, Patrick Robert Verhoest, Peter Justin Mikochik, John Charles Murray, Xinjun Hou
  • TREATMENT WITH ANTI-PCSK9 ANTIBODIES
    Publication number: 20170306051
    Abstract: The present invention relates to therapeutic dosing regimens utilizing a dose reduction strategy for treating disorders characterized by marked elevations of low density protein cholesterol (LDL-C) in the plasma of a patient. The subject therapeutic dosing regimens involve delivering as a single administration or plurality of administrations of an anti-proprotein convertase subtilisin kexin type 9 (PCSK9) antagonist antibody as an initial dose of at least about 100 mg, and delivering as a single administration or plurality of administrations at a subsequent dose in an amount that is about the same as the initial dose, or at least half the initial dose after the patient has a LDL-C level at or below about 25, 20, 15 or 10 mg/dL, preferably at or below 10 mg/dL.
    Type: Application
    Filed: September 9, 2015
    Publication date: October 26, 2017
    Applicant: PFIZER INC.
    Inventors: Anne Barbara CROPP, Albert KIM, David Raymond PLOWCHALK, Kevin Richard SWEENEY, Ellen Qiao WANG
  • SUBSTITUTED DIHYDROISOQUINOLINONE COMPOUNDS
    Publication number: 20170298048
    Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 19, 2017
    Applicant: Pfizer Inc.
    Inventors: Michael Raymond Collins, Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Daniel Tyler Richter, Scott Channing Sutton, Martin James Wythes
  • Diacylglycerol acyltransferase 2 inhibitors
    Patent number: 9789110
    Abstract: Compounds of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: October 17, 2017
    Assignee: Pfizer Inc.
    Inventor: Kentaro Futatsugi
  • Bruton's Tyrosine Kinase Inhibitors
    Publication number: 20170283393
    Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (BTK). Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the BTK inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseeases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
    Type: Application
    Filed: June 16, 2017
    Publication date: October 5, 2017
    Applicant: Pfizer Inc.
    Inventors: John Robert Springer, Balekudru Devadas, Danny James Garland, Margaret Lanahan Grapperhaus, Seungil Han, Susan Landis Hockerman, Robert Owen Hughes, Eddine Saiah, Mark Edward Schnute, Shaun Raj Selness, Daniel Patrick Walker, Zhao-Kui Wan, Li Xing, Christoph Wolfgang Zapf, Michelle Ann Schmidt
  • SOLID MOLECULAR DISPERSION OF FESOTERODINE HYDROGEN FUMARATE AND POLYMERIC BINDER
    Publication number: 20170281586
    Abstract: The present invention relates to solid molecular dispersion of fesoterodine hydrogen fumarate and a polymeric binder. The invention also relates to an inert core bead or particle which is coated with said solid molecular dispersion and to pharmaceutical formulations comprising such coated beads or particles.
    Type: Application
    Filed: April 12, 2017
    Publication date: October 5, 2017
    Applicant: Pfizer Limited
    Inventors: Roland Bodmeier, Alan Francis Carmody, Mesut Ciper, Anne Therese Gustaaf De Paepe, John Mark Heimlich, Martin Korber, Mathias Walther, Neil Feeder
  • Anti-PTK7 antibody-drug conjugates
    Patent number: 9777070
    Abstract: The present invention provides anti-PTK7 antibody-drug conjugates and methods for preparing and using the same.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: October 3, 2017
    Assignees: PFIZER INC, ABBVIE STEMCENTRX LLC
    Inventors: Marc Isaac Damelin, Puja Sapra, Alexander John Bankovich, Scott J. Dylla
  • Saccharides and uses thereof
    Patent number: 9777076
    Abstract: The invention relates to novel saccharides and uses thereof. In one aspect, the invention relates to a saccharide having a legionaminic acid moiety, a N-acetylgalactosamine moiety, a galactose moiety, and a glucose moiety. In another aspect, the invention relates to a saccharide having an altruronic acid moiety, a fucose moiety, and a glucose moiety. In yet another aspect, the invention relates to a saccharide having a repeating unit of a glycerol phosphate moiety and a glucose moiety, wherein the saccharide is from Enterococcus faecium. In a further aspect, the invention relates to a saccharide having a repeating unit of -6-?-D-Fruf-2, wherein Fru is a fructose moiety, wherein the saccharide is from Enterococcus faecium. In another aspect, the invention relates to an isolated antibody or fragment thereof that specifically binds to a saccharide described herein and uses thereof.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: October 3, 2017
    Assignee: Pfizer Inc.
    Inventors: Robert G. K. Donald, Srinivas Kodali, Evguenii Vinogradov
  • 2-THIOPYRIMIDINONES
    Publication number: 20170275257
    Abstract: Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Applicant: PFIZER INC.
    Inventor: Roger Ruggeri
  • CRYSTALLINE SOLID FORMS OF 6-CARBOXY-2-(3,5-DICHLOROPHENYL)-BENZOXAZOLE
    Publication number: 20170273953
    Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.
    Type: Application
    Filed: August 31, 2015
    Publication date: September 28, 2017
    Applicant: Pfizer Inc.
    Inventors: Kevin Paul GIRARD, Andrew J. JENSEN, Kris Nicole JONES
  • 2-thiopyrimidinones
    Patent number: 9771332
    Abstract: Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: September 26, 2017
    Assignee: Pfizer Inc.
    Inventor: Roger Ruggeri
  • N-(2-(2-amino-6-substituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]OXAZIN-8a(8H)-yl)-thiazol-4-yl) amides
    Patent number: 9771379
    Abstract: The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, wherein the variables R1, R2, R3, R4 and X are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: September 26, 2017
    Assignee: PFIZER INC.
    Inventors: Michael Aaron Brodney, Christopher Ryan Butler, Lei Zhang, Brian Thomas O'Neill
  • Crystalline solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole
    Patent number: 9770441
    Abstract: The present invention relates to solid forms of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for their preparation. The invention is also directed to pharmaceutical compositions containing at least one solid form and to the therapeutic or prophylactic use of such solid forms and compositions.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: September 26, 2017
    Assignee: Pfizer Inc.
    Inventors: Kevin Paul Girard, Andrew J. Jensen, Kris Nicole Jones