Patents Assigned to Pfizer
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
    Publication number: 20100184737
    Abstract: The present invention relates to compounds of Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 22, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman, Edward F. Kleinman, Brian T. O'Neill, Yuhpyng L. Chen
  • Synthesis of diaryl pyrazoles
    Patent number: 7759497
    Abstract: A process for the qualitative preparation of 3-haloalkyl-1H-pyrazoles suitable for efficient, high payload commercial application.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: July 20, 2010
    Assignee: Pfizer Inc.
    Inventors: Leo J. Letendre, William D. McGhee, Cynthia Snoddy, George Klemm, Henry T. Gaud
  • Portable position determining device
    Patent number: 7760137
    Abstract: A position determining device is disclosed comprising a satellite navigation receiver for automatically providing computed position information, when the device has changed its position relative to a predetermined location, to a paging transmitter for transmission to a paging receiver for readout of the computed position information. The readout may be in the form of coordinates and may be accompanied by a message or alarm. The device may be configured as a portable unit of small size and economical manufacture.
    Type: Grant
    Filed: April 23, 2007
    Date of Patent: July 20, 2010
    Assignee: Pfizer, Inc.
    Inventors: Jennifer Martucci, Eugene F. Fowler, Joseph C. McAlexander
  • Hydroxypropyl Methyl Cellulose Hard Capsules and Process of Manufacture
    Publication number: 20100168410
    Abstract: A composition for manufacture of hard hydroxypropyl methyl cellulose capsules comprising a film forming material of hydroxypropyl methyl cellulose having a methoxy content of 27.0-30.0% (w/w), and a hydroxypropoxy content of 4.0-7.5% and as a 2% weight solution, a viscosity of 3.5-6.0 cPs at 20° C., dipping compositions, process for manufacture of hard hydroxypropyl methyl cellulose capsules according to a dip coating process and hard capsule shells.
    Type: Application
    Filed: October 17, 2007
    Publication date: July 1, 2010
    Applicant: PFIZER PRODUCTS INC.
    Inventors: Dominique Nicolas Cade, David He Xinwe
  • IMIDAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS
    Publication number: 20100168107
    Abstract: The present invention relates to compounds of the Formula I wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of the Formula I have activity inhibiting production of A?-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula I.
    Type: Application
    Filed: March 12, 2010
    Publication date: July 1, 2010
    Applicant: Pfizer Inc
    Inventors: Michael A. Brodney, Karen J. Coffman
  • IGE CH3 PEPTIDE VACCINE
    Publication number: 20100158933
    Abstract: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
    Type: Application
    Filed: December 9, 2009
    Publication date: June 24, 2010
    Applicant: PFIZER VACCINES LLC
    Inventors: ALAN DANIEL BROWN, BRIAN ROBERT CHAMPION, CLARE CHRISTY, DAVID PAUL GERVAIS, LYN HOWARD JONES, ANNE MARIA KRISTINA KJERRSTROM, DAVID CAMERON PRYDE, LEE RICHARD ROBERTS, DAVID MICHAEL WYATT
  • Pyrimidine derivatives for the treatment of abnormal cell growth
    Patent number: 7741336
    Abstract: The present invention relates to a compound of the formula 1 wherein R1-R4 are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: June 22, 2010
    Assignee: Pfizer Inc.
    Inventors: John Charles Kath, Michael Joseph Luzzio
  • Benzimidazolone carboxylic acid derivatives
    Patent number: 7737163
    Abstract: This invention relates to compounds of the formula (I): wherein R1, R2, R3, A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 receptor activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders such as cardiac failure and heart arrhythmia, diabetes and apnea syndrome.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: June 15, 2010
    Assignee: Pfizer Inc.
    Inventors: Koji Ando, Satoru Iguchi, Noriaki Murase, Yoshinori Murata, Toyoharu Numata, Hiroki Sone, Chikara Uchida, Tatsuo Ueki
  • Canine combination vaccines
    Patent number: 7736658
    Abstract: This invention relates to vaccines and methods for protecting dogs against disease caused by Bordetella bronchiseptica. This invention also relates to combination vaccines and methods for protecting dogs against disease or disorder caused by canine pathogens, for example, infectious tracheobronchitis caused by Bordetella bronchiseptica, canine distemper caused by canine distemper (CD) virus, infectious canine hepatitis (ICH) caused by canine adenovirus type 1 (CAV-1), respiratory disease caused by canine adenovirus type 2 (CAV-2), canine parainfluenza caused by canine parainfluenza (CPI) virus, enteritis caused by canine coronavirus (CCV) and canine parvovirus (CPV), and leptospirosis caused by Leptospira Bratislava, Leptospira canicola, Leptospira grippotyphosa, Leptospira icterohaemorrhagiae or Leptospira pomona. The vaccines of the present invention include a Bordetella bronchiseptica p68 antigen.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: June 15, 2010
    Assignee: Pfizer Inc.
    Inventors: Paul J. Dominowski, Joseph C. Frantz, Richard L. Krebs, Shelly L. Shields, Robert Greg Sorensen
  • Multiparticulate compositions with improved stability
    Patent number: 7736672
    Abstract: A process is described for producing drug-containing multiparticulates with improved stability, characterized by an improvement in one or more of chemical stability, physical stability, or dissolution stability.
    Type: Grant
    Filed: December 3, 2004
    Date of Patent: June 15, 2010
    Assignee: Pfizer, Inc.
    Inventors: Roderick J. Ray, Leah E. Appel, Dwayne Thomas Friesen, Marshall D. Crew, Joshua R. Shockey
  • Triazolopyrazine derivatives
    Patent number: 7732604
    Abstract: The invention relates to compounds of the formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and R4 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: June 8, 2010
    Assignee: Pfizer Inc.
    Inventors: Hengmiao Cheng, Jingrong Jean Cui, Jacqui Elizabeth Hoffman, Lei Jia, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Hong Shen, Michelle Bich Tran-Dubé
  • CHIMERIC PESTIVIRUSES
    Publication number: 20100136055
    Abstract: The present invention relates to chimeric pestiviruses having utility as immunogenic compositions and vaccines. Also described herein are methods and kits for treating or preventing the spread of bovine viral diarrhea virus infection, as well as methods and kits for differentiating between vaccinated and wild-type infected animals.
    Type: Application
    Filed: November 24, 2009
    Publication date: June 3, 2010
    Applicant: Pfizer Inc.
    Inventors: Yugang Luo, Siao-Kun Wan Welch, Ying Yuan, Robert Gerard Ankenbauer
  • 4-METHYLPYRIDOPYRIMIDINONE COMPOUNDS
    Publication number: 20100137279
    Abstract: The present invention is directed to novel 4-methylpyridopyrimidinone compounds of Formula (I), and to salts thereof, their synthesis, and their use as inhibitors of phosphoinositide 3-kinase alpha (PI3-K?).
    Type: Application
    Filed: February 9, 2010
    Publication date: June 3, 2010
    Applicant: Pfizer Inc.
    Inventors: Hengmiao Cheng, Dilip Bhumralkar, Klaus Ruprecht Dress, Jacqui Elizabeth Hoffman, Mary Catherine Johnson, Robert Steven Kania, Phuong Thi Quy Le, Mitchell David Nambu, Mason Alan Pairish, Michael Bruno Plewe, Khanh Tuan Tran
  • Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
    Patent number: 7727749
    Abstract: The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: June 1, 2010
    Assignee: Pfizer, Inc.
    Inventors: Michael P. Burns, Justin K. Weaver, John Wing Wong
  • Pyrrolo[2,3-b]pyridine derivatives active as kinase inhibitors and pharmaceutical compositions comprising them
    Patent number: 7728140
    Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: June 1, 2010
    Assignee: Pfizer Italia S.r.l.
    Inventors: Barbara Salom, Matteo D'Anello, Maria Gabriella Brasca, Patrizia Giordano, Katia Martina, Francesco Angelucci, Frederick Arthur Brookfield, William John Trigg, Edward Andrew Boyd, Jonathan Anthony Larard
  • Highly selective norepinephrine reuptake inhibitors and methods of using the same
    Patent number: 7723334
    Abstract: Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 25, 2010
    Assignee: Pfizer Inc.
    Inventors: Erik H. F. Wong, Saeeduddin Ahmed, Robert C. Marshall, Robert McArthur, Duncan P. Taylor, Lars Birgerson, Pasquale Cetera
  • Substituted bicyclolactam compounds
    Patent number: 7718645
    Abstract: The invention provides compounds of formula (1), and the pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5a, R5b, R5c, R5d, Q, A, Z, and R7 are as described herein; compositions thereof; and uses thereof.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: May 18, 2010
    Assignee: Pfizer Inc.
    Inventors: Robert L. Dow, Michael J. Munchhof
  • Apparatus and method for dispensing small quantities of particles
    Patent number: 7712634
    Abstract: An apparatus for dispensing small quantities of particles, the apparatus comprises a hopper provided with a sieve at a bottom portion thereof, the hopper in use containing powder to be dispensed therefrom through the sieve, a support for the hopper, the support holding a portion of the hopper so that the hopper can in use be held above a container into which the dispensed powder is to be received, and at least one actuator for delivering impact energy to the hopper for causing powder to be dispensed through the sieve when the hopper receives the impact energy, wherein the at least one actuator is arranged to deliver impact energy to the hopper from different directions and/or at different locations on the hopper. There is also provided a method of dispensing small quantities of particles.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: May 11, 2010
    Assignee: Pfizer Limited
    Inventors: Donald Bruce Atherton MacMichael, William Robert Charles Opie, Simon Mark Bryant, Imogen Gill
  • ANTI-IGE VACCINES
    Publication number: 20100113361
    Abstract: The present invention provides compositions and methods for the use of antigenic peptides derived from the Fc portion of the epsilon heavy chain of an IgE molecule as vaccines for the treatment and prevention of IgE-mediated allergic disorders. In particular, the invention provides compositions, methods for the treatment and prevention of IgE-mediated allergic disorders comprising an immunogenic amount of one or more antigenic peptides derived from the CH3 domain or junction of Ch-3/CH4 domain of an IgE molecule and methods for the evaluation of IgE mediated allergies in dogs.
    Type: Application
    Filed: November 24, 2009
    Publication date: May 6, 2010
    Applicant: PFIZER INC.
    Inventors: Mohamad A. Morsey, Michael G. Sheppard, David W. Wheeler
  • Echinocandin pharmaceutical formulations containing micelle-forming surfactants
    Patent number: 7709444
    Abstract: Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: May 4, 2010
    Assignee: Pfizer Inc.
    Inventors: Nathaniel Milton, Kenneth Philip Moder, James Lawrence Sabatowski, Stephanie Ann Sweetana