Patents Assigned to Pfizer
  • Salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-?, ?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
    Patent number: 7534810
    Abstract: Novel salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: May 19, 2009
    Assignee: Pfizer Inc.
    Inventors: Anthony Michael Campeta, Joseph F. Krzyzaniak, Jason Albert Leonard
  • CHEMICAL COMPOUNDS
    Publication number: 20090124635
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors. Modulators of the CCR5 receptor may be useful in the treatment of various inflammatory diseases and conditions, and in the treatment of infection by HIV and genetically related retroviruses.
    Type: Application
    Filed: January 12, 2006
    Publication date: May 14, 2009
    Applicant: PFIZER INC.
    Inventors: Christopher Gordon Barber, David Clive Blakemore, David Cameron Pryde, James Welsh Auld Kinnaird
  • Method of Measuring Amyloid-Beta Peptides
    Publication number: 20090123952
    Abstract: The present invention relates to methods for measuring A? peptides in a sample, particularly a sample of blood, such as whole blood and plasma, and to methods of determining whether a compound alters the amount of A? produced by a cell or animal.
    Type: Application
    Filed: November 14, 2005
    Publication date: May 14, 2009
    Applicants: PFIZER, INC., ELAN PHARMACEUTICALS
    Inventor: John Randall Slemmon
  • Therapeutic compounds
    Patent number: 7531530
    Abstract: The invention relates to trycyclic lactam indole derivatives and triacyclic lactam benzimodole derivatives and their use in inhibiting the activity of PARP enzyme. The invention also relates to the use of these compounds in the preparation of medicaments.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: May 12, 2009
    Assignees: Cancer Research Technology Limited, Pfizer
    Inventors: Thomas Helleday, Nicola Curtin
  • Method of treating diseases associated with altered kinase activity with bicyclo-pyrazoles
    Patent number: 7531531
    Abstract: Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: May 12, 2009
    Assignee: Pfizer Italia S.r.l.
    Inventors: Daniele Fancelli, Valeria Pittalà, Mario Varasi
  • Anti-Ctla-4 Antibody and Cpg-Motif-Containing Synthetic Oligodeoxynucleotide Combination Therapy for Cancer Treatment
    Publication number: 20090117132
    Abstract: The invention relates to administration of an anti-CTLA-4 antibody, particularly human antibodies to human CTLA-4, such as those having amino acid sequences of antibodies 3.1.1, 4.1.1, 4.8.1, 4.10.2, 4.13.1, 4.14.3, 6.1.1, 11.2.1, 11.6.1, 11.7.1, 12.3.1.1, 12.9.1.1, and MDX-010, in combination with an immunostimulatory nucleotide, i.e, CpG ODN PF3512676, for treatment of cancer. The invention relates to administering a combination of an anti-CTLA-4 antibody and CpG ODN PF3512676 as neoadjuvant, adjuvant, first-line, second-line, and third-line therapy of cancer, whether localized or metastasized, and at any point(s) along the disease continuum (e.g, at any stage of the cancer).
    Type: Application
    Filed: June 30, 2006
    Publication date: May 7, 2009
    Applicants: Pfizer, Inc., Coley Pharmaceutical Group, Inc.
    Inventors: David Robert John Readett, Jarl Ulf Birger Jungnelius, Jesus Gomez-Navarro, Douglas Hanson, Arthur M. Krieg
  • Sulfonamide derivatives for the treatment of diseases
    Patent number: 7528170
    Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: May 5, 2009
    Assignee: Pfizer Inc.
    Inventors: Alan Daniel Brown, Mark Edward Bunnage, Paul Alan Glossop, Kim James, Charlotte Alice Louise Lane, Russel Andrew Lewthwaite, Ian Brian Moses, David Anthony Price, Nicholas Murray Thomson
  • Anti-M-CSF Antibody Compositions
    Publication number: 20090110681
    Abstract: The present invention provides for compositions of anti-M-CSF antibodies comprising a chelating agent and/or histidine. Also provided are methods of treating M-CSF-mediated disorders with pharmaceutical formulations of anti-M-CSF anti-bodies, including inflammatory diseases and neoplasia disorders.
    Type: Application
    Filed: March 2, 2006
    Publication date: April 30, 2009
    Applicant: Pfizer, Inc.
    Inventors: James Carroll, Tapan K. Das, Corey M. Allan, Sandeep Nema, David Zeng
  • Antibacterial agents
    Patent number: 7524860
    Abstract: The present invention is directed to a new class of triazolopyridine derivatives, to their use as antimicrobials, and to pharmaceuticals containing these compounds.
    Type: Grant
    Filed: September 23, 2005
    Date of Patent: April 28, 2009
    Assignee: Pfizer Inc.
    Inventors: David Charles Donnell Butler, Huifen Chen, Vishnumurthy Ramachandra Hegde, Chris Limberakis, Ravindra Madhukar Rasne, Richard John Sciotti, Jeremy Tyson Starr
  • Pyrazole compounds for treatment of neurodegenerative disorders
    Patent number: 7521464
    Abstract: The invention provides compounds of Formula I: wherein R1, R2, R3, R4, R6, R7, R8 and A are as defined. Compounds of formula I have activity inhibiting production of A?-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: April 21, 2009
    Assignee: Pfizer Inc.
    Inventors: Yuhpyng L. Chen, Spiros Liras, Robert L. Rosati, Martin P. Allen
  • Amino acids with affinity for the ?2?-protein
    Patent number: 7517909
    Abstract: This invention relates to certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: April 14, 2009
    Assignee: Pfizer Inc
    Inventors: Andrew John Thorpe, David Juergen Wustrow
  • Substituted aryloxymethyl bicyclicmethyl acetamide compounds
    Patent number: 7514457
    Abstract: Compounds of the general formula (I): pharmaceutical compositions comprising a compound of general formula (I); and methods of treating disease conditions caused by overactivation of the VR1 receptor by administering a compound of general formula (I) to a subject.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: April 7, 2009
    Assignee: Pfizer Inc.
    Inventors: Tadashi Inoue, Satoshi Nagayama, Yuji Shishido
  • Substituted arylpyrazoles
    Patent number: 7514464
    Abstract: This invention relates to a combination product comprising a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7 and R9 are as described herein, and one or more further biologically active compounds as described herein, particularly anti-parasitic agents.
    Type: Grant
    Filed: June 15, 2005
    Date of Patent: April 7, 2009
    Assignee: Pfizer Limited
    Inventors: Denis Billen, Nathan Anthony Logan Chubb, David Morris Gethin, Kim Thomas Hall, Lee Richard Roberts, Nigel Derek Arthur Walshe
  • Triazolopyridinylsulfanyl derivatives as p38 MAP kinase inhibitors
    Patent number: 7511057
    Abstract: A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: March 31, 2009
    Assignee: Pfizer Inc.
    Inventors: John Paul Mathias, David Simon Millan, Russell Andrew Lewthwaite, Christopher Phillips
  • Aminoindazole derivatives active as kinase inhibitors
    Patent number: 7511136
    Abstract: Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: March 31, 2009
    Assignee: Pfizer Italia S.r.l.
    Inventors: Raffaella Amici, Matteo D'Anello, Katia Martina, Barbara Salom, Anna Vulpetti
  • COMBINATIONS AND METHODS OF USING AN IMMUNOMODULATORY OLIGODEOXYNUCLEOTIDE
    Publication number: 20090082295
    Abstract: The present invention relates to combination therapies for the treatment of cancer. The combination of agents include oligonucleotides and one or more chemotherapeutic agents.
    Type: Application
    Filed: November 13, 2006
    Publication date: March 26, 2009
    Applicant: PFIZER INC.
    Inventors: Jarl Ulf Birger Jungnelius, David Robert John Readett, Louis J. Denis
  • Substituted Pyrrolo-Pyrazole Derivatives as Kinase Inhibitors
    Publication number: 20090082346
    Abstract: Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
    Type: Application
    Filed: July 29, 2008
    Publication date: March 26, 2009
    Applicant: Pfizer Italia S.r.l.
    Inventors: Maria Gabriella Brasca, Raffaella Amici, Daniele Fancelli, Marcella Nesi, Paolo Orsini, Fabrizio Orzi, Patrick Roussel, Anna Vulpetti, Paolo Pevarello
  • Cyclopentapyridine and tetrahydroquinoline derivatives
    Patent number: 7507732
    Abstract: 6,7-Dihydro-5H-cyclopenta[b]pyridine and 5,6,7,8-tetrahydroquinoline compounds of Formula (I), including salts, hydrates and solvates thereof, that act as 5-HT2 receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2c receptors are described herein.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: March 24, 2009
    Assignee: Pfizer Inc.
    Inventors: Bruce A. Lefker, Kevin K. -C. Liu, Hou Chen, Steven Blair Coffey
  • Androgen modulators
    Patent number: 7507860
    Abstract: The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: March 24, 2009
    Assignee: Pfizer Inc.
    Inventors: Lain-Yen Hu, Huangshu Lei, Daniel Y. Du, Bruce A. Lefker, Yvonne Dorothy Smith, Victor Fedij
  • Spirocyclic derivatives
    Patent number: 7507742
    Abstract: The invention provides compounds of formula (I): wherein: m is 0, 1 or 2; X is O, S or N—CN; R is F, Cl or CN; A is a C3-6 cycloalkylene group optionally substituted with a C1-4 alkyl group; and B is a single bond or a C1-2 alkylene group; or a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. The compounds are PDE7 inhibitors and have a number of therapeutic applications, particularly in the treatment of pain, especially neuropathic pain.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: March 24, 2009
    Assignee: Pfizer Inc.
    Inventors: David J. Rawson, Nigel A. Swain