Abstract: A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.
Type:
Application
Filed:
May 24, 2007
Publication date:
February 11, 2010
Applicant:
Phamacofoce, Inc.
Inventors:
Thomas E. Jenkins, Aleksandr Kolesnikov