Patents Assigned to Phanos Technologies, Inc.
  • Fluorescent membrane intercalating probes and methods for their use
    Patent number: 9597416
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: March 21, 2017
    Assignee: PHANOS TECHNOLOGIES, INC.
    Inventor: Brian D. Gray
  • FLUORESCENT MEMBRANE INTERCALATING PROBES AND METHODS FOR THEIR USE
    Publication number: 20150044143
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Applicant: PHANOS TECHNOLOGIES, INC.
    Inventor: Brian D. Gray
  • Fluorescent membrane intercalating probes and methods for their use
    Patent number: 8894976
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: November 17, 2006
    Date of Patent: November 25, 2014
    Assignee: Phanos Technologies, Inc.
    Inventor: Brian D. Gray
  • Fluorescent membrane intercalating probes and methods for their use
    Patent number: 8029767
    Abstract: The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: October 4, 2011
    Assignee: Phanos Technologies, Inc.
    Inventor: Brian D. Gray
  • FLUORESCENT MEMBRANE INTERCALATING PROBES AND METHODS FOR THEIR USE
    Publication number: 20100003196
    Abstract: The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Application
    Filed: December 8, 2008
    Publication date: January 7, 2010
    Applicant: Phanos Technologies, Inc.
    Inventor: Brian D. GRAY
  • FLUORESCENT MEMBRANE INTERCALATING PROBES AND METHODS FOR THEIR USE
    Publication number: 20090304598
    Abstract: The invention relates to a family of dyes which fluoresce in the UV-VIS, far red and near infrared wavelengths of the spectrum and possess asymmetric lipophilic alkyl chains. The dyes of the invention are soluble in commercially available membrane staining dyes, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well-retained therein. Methods of utilizing the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Application
    Filed: November 17, 2006
    Publication date: December 10, 2009
    Applicant: Phanos Technologies, Inc.
    Inventor: Brian D. Gray
  • Fluorescent membrane intercalating probes
    Patent number: 7462347
    Abstract: The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably possess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: December 9, 2008
    Assignee: Phanos Technologies, Inc.
    Inventor: Brian D. Gray
  • Fluorescent membrane intercalating probes
    Publication number: 20060193780
    Abstract: The invention relates to a family of cyanine dyes which fluoresce in the far red and near infra red wavelengths of the spectrum and preferably prossess lipophilic side chains. The dyes of the invention are soluble in commercially available membrane staining vehicles, are useful as probes for rapidly staining lipophilic structures such as membranes in cells or isolated from cells, and are well retained therein. Methods of using the dyes to detect stained cells both in vivo and in vitro are also disclosed.
    Type: Application
    Filed: February 3, 2006
    Publication date: August 31, 2006
    Applicant: Phanos Technologies, Inc.
    Inventor: Brian Gray
  • Method for detecting abnormal epithelial cell shedding
    Patent number: 5804389
    Abstract: A method for detecting abnormal cell shedding rates of mature epithelial cells of a warm-blooded animal, such as the epithelial cells of the gastric or colonic glands. A labeling composition containing, e.g., a cyanine dye is applied to epithelial cells, following which the site is observed over time. Abnormal cell shedding rates are indicative of disease states such as carcinoma.
    Type: Grant
    Filed: December 29, 1995
    Date of Patent: September 8, 1998
    Assignee: Phanos Technologies, Inc.
    Inventor: Masahiro Tada
  • Compounds, compositions and methods for binding bio-affecting substances to surface membranes of bio-particles
    Patent number: 5665328
    Abstract: Compounds, compositions, their methods of preparation and use in binding bio-affecting substances to the surface membrane of bioparticles, such as enkaryotic cells, without producing appreciable detrimental effect on morphology or physiological function of cells.
    Type: Grant
    Filed: December 1, 1992
    Date of Patent: September 9, 1997
    Assignee: Phanos Technologies, Inc.
    Inventors: Paul Karl Horan, Sue Ellen Slezak, Bruce D. Jensen