Abstract: A system for neutralizing prescription drugs, narcotics and other harmful substances, including a staging area for an initial collection and sorting of prescription drugs, narcotics and other harmful substances to be neutralized, a containment chamber assembly operatively connected to the staging area for granulating the prescription drugs, narcotics and other harmful substances, a waste grinder/vacuum assembly operatively connected to the containment chamber for destroying any packaging that contained the prescription drugs, narcotics and other harmful substances, and a neutralizing assembly operatively connected to the containment chamber for neutralizing the granulated prescription drugs, narcotics and other harmful substances, with a neutralizing agent.