Abstract: The present invention provides methods of reducing cellular production of amyloid beta (A&bgr;) from amyloid precursor protein (APP) by reducing Asp2 transcription or translation in cells.
Type:
Grant
Filed:
April 12, 2000
Date of Patent:
September 28, 2004
Assignee:
Pharamcia & Upjohn Company
Inventors:
Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
Type:
Grant
Filed:
October 20, 2000
Date of Patent:
February 18, 2003
Assignee:
Pharamcia & Upjohn Company
Inventors:
Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins