Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.
Type:
Grant
Filed:
July 10, 2009
Date of Patent:
June 18, 2013
Assignees:
Pharma IP General Incorporated Association, Pharma Design, Inc., Shizuoka Prefecture, Kumamoto Health Science University, Kabushiki Kaisha Yakult Honsha
Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
Type:
Application
Filed:
December 28, 2010
Publication date:
November 29, 2012
Applicants:
GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION, PHARMA DESIGN, INC., KABUSHIKI KAISHA YAKULT HONSHA, KUMAMOTO HEALTH SCIENCE UNIVERSITY, SHIZUOKA PREFECTURE
Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.
Type:
Application
Filed:
July 10, 2009
Publication date:
July 14, 2011
Applicants:
PHARMA IP GENERAL INCORPORATED ASSOCIATION, PHARMA DESIGN, INC., SHIZUOKA PREFECTURE, KUMAMOTO HEALTH SCIENCE UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
Abstract: A light transmitting device for attachment to a stethoscope headpiece which provides for reversible engagement of the device to the headpiece so that the same can be removed such as for repairs or replacement of batteries. The transmitting device provides a source of light without interfering with the operation of the stethoscope and can be provided without retooling the stethoscope to accommodate a source of light.
Type:
Grant
Filed:
August 8, 2003
Date of Patent:
August 23, 2005
Assignee:
Pharma Design Inc
Inventors:
Richard Costa, Hung Mach, Matthew T. Coe
Abstract: A compliance ring for indicating into which nostril medication has last been sprayed, comprises fixed and movable rings engaged to each other and held between the actuator and the reservoir bottle of the dispenser of the medication. The fixed ring has a cylindrical skirt which is interrupted by a rectangular recess and a movable ring has an outwardly projecting indicator which, with rotation of the movable ring in the fixed ring, moves from one position to the other. In one position, the indicator registers with the letter "R" on the upper surface of the fixed ring, and in the opposition position, the indicator registers with the letter "L". The letters "L" and "R" indicate left and right nostrils which have received medication or are meant to receive medication next.