Patents Assigned to PHARMAAWARE SEPSIS B.V.
  • Use of alkaline phosphatase for preventing or reducing liver disease
    Patent number: 8735087
    Abstract: The present invention provides a use for alkaline phosphatase for the manufacture of a medicament for the prevention or reduction of toxic LPS influx through a mucosal lining of a mammalian body cavity. A source of alkaline phosphatase is administered for the prophylaxis or treatment of LPS mediated or exacerbated diseases. The invention also provides compositions comprising a source of alkaline phosphatase for the prevention or reduction of (toxic) LPS influx or passage through mucosal layers.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: May 27, 2014
    Assignee: PharmAAware Sepsis B.V.
    Inventors: Rudi Brands, Klaas Poelstra
  • Alkaline phosphatase for treating an inflammatory disease of the gastro-intestinal tract
    Patent number: 8574863
    Abstract: The present invention provides a use for alkaline phosphatase for the manufacture of a medicament for the prevention or reduction of toxic LPS influx through a mucosal lining of a mammalian body cavity. A source of alkaline phosphatase is administered for the prophylaxis or treatment of LPS mediated or exacerbated diseases. The invention also provides compositions comprising a source of alkaline phosphatase for the prevention or reduction of (toxic) LPS influx or passage through mucosal layers.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: November 5, 2013
    Assignee: PharmAAware Sepsis B.V.
    Inventors: Rudi Brands, Klaas Poelstra
  • MEANS AND METHOD FOR TREATING AND/OR PREVENTING NECROTIZING ENTEROCOLITIS
    Publication number: 20110142817
    Abstract: Compositions comprising a source of alkaline phosphatase that prevent or reduce toxic influx of lipopolysaccharide (LPS) through mucosal layers of a mamalian body cavity and methods of using these compositions for those purposes are disclosed. Such a source of alkaline phosphatase, preferably in a medical food such as infant milk formula, is eaten, drunk or otherwise administered for prophylaxis or treatment of LPS-mediated or LPS-exacerbated disease.
    Type: Application
    Filed: July 6, 2010
    Publication date: June 16, 2011
    Applicant: PHARMAAWARE SEPSIS B.V.
    Inventors: Rudi BRANDS, Klaas Poelstra
  • Use of Alkaline Phosphatase for the Detoxification of Lps Present at Mucosal Barriers
    Publication number: 20090010912
    Abstract: The present invention provides a use for alkaline phosphatase for the manufacture of a medicament for the prevention or reduction of toxic LPS influx through a mucosal lining of a mammalian body cavity. A source of alkaline phosphatase is administered for the prophylaxis or treatment of LPS mediated or exacerbated diseases. The invention also provides compositions comprising a source of alkaline phosphatase for the prevention or reduction of (toxic) LPS influx or passage through mucosal layers.
    Type: Application
    Filed: February 4, 2005
    Publication date: January 8, 2009
    Applicant: PHARMAAWARE SEPSIS B.V.
    Inventors: Rudi Brands, Klaas Poelstra