Abstract: Spherically-shaped pharmaceutical pellets are produced using a novel spheronization apparatus in a continuous melt spheronization process in which an active pharmaceutical agent is blended with various excipients, fed to an extruder, cut and subsequently fed to the novel spheronizer for continuously producing uniform, spherically-shaped pellets. The pellets may be further coated so as to provide immediate or various modified release characteristics.
Type:
Grant
Filed:
May 15, 2006
Date of Patent:
August 10, 2010
Assignees:
American Leistritz Extruder Corp., Pharmaceutical Technology Solutions, LLC
Inventors:
Isaac Ghebre-Sellassie, Charles Martin, Bert Elliot