Patents Assigned to Pharmaceutics International, Inc.
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Patent number: 9770509Abstract: The invention provides a formulation comprising (a) a drug that is poorly water-soluble, (b) at least one surfactant, and (c) at least one polar lipid, wherein the formulation is substantially free of a polar solvent, as well as methods of preparing the formulation and methods of increasing the bioavailability of a drug using the formulation.Type: GrantFiled: July 17, 2015Date of Patent: September 26, 2017Assignee: Pharmaceutics International, Inc.Inventor: Emadeldin Hassan
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Patent number: 9662300Abstract: The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.Type: GrantFiled: December 3, 2013Date of Patent: May 30, 2017Assignee: Pharmaceutics International, Inc.Inventors: EmadEldin M. Hassan, Sridhar Gumudavelli
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Publication number: 20140155494Abstract: This invention relates to macromolecular complexes useful in drug delivery systems, specifically tri-molecular complexes made between a water-soluble polymer and an acid-insoluble polymer in presence of a bridging molecule. In one aspect, the invention relates to a tri-molecular complex comprising gelatin, acrylic acid/methacrylic acid copolymers, and arginine for use in a soft capsule dosage form. In another aspect, the invention is directed to a tri-molecular complex a hydrophilic, film-forming, water-soluble polymer, a second water-soluble polymer, and a bridging molecule, wherein the second water-soluble polymer is less water-soluble than the hydrophilic, film-forming, water-soluble polymer.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Pharmaceutics International, Inc.Inventors: EmadEldin M. Hassan, Sridhar Gumudavelli
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Publication number: 20140093562Abstract: The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.Type: ApplicationFiled: December 3, 2013Publication date: April 3, 2014Applicant: Pharmaceutics International, Inc.Inventors: EmadEldin M. Hassan, Sridhar Gumudavelli
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Publication number: 20130122051Abstract: The invention provides a method of preparing a pharmaceutical composition comprising: (a) combining progesterone particles with a liquid carrier to provide a mixture; (b) wet-milling the mixture to provide a wet-milled progesterone composition; and (c) processing the wet-milled progesterone composition to provide a pharmaceutical composition. Pharmaceutical compositions prepared by the method are also provided.Type: ApplicationFiled: May 25, 2012Publication date: May 16, 2013Applicant: PHARMACEUTICS INTERNATIONAL, INC.Inventors: Syed E. Abidi, Eric R. Coutinho, Sridhar Gumudavelli, Swati Agrawal, Rampurna P. Gullapalli
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Publication number: 20130115283Abstract: The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.Type: ApplicationFiled: December 26, 2012Publication date: May 9, 2013Applicant: Pharmaceutics International, Inc.Inventor: Pharmaceutics International, Inc.
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Publication number: 20110052679Abstract: The invention provides a composition consisting essentially of a solid naproxen concentrate, wherein the solid naproxen concentrate comprises (a) a solid naproxen free acid and (b) a solid naproxen alkali salt, and wherein at least 90% of the weight of the solid naproxen concentrate is naproxen free acid and naproxen alkali salt, as well methods of producing such a solid naproxen concentrate.Type: ApplicationFiled: August 25, 2009Publication date: March 3, 2011Applicant: Pharmaceutics International, Inc.Inventors: EmadEldin M. Hassan, Sridhar Gumudavelli
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Publication number: 20090253808Abstract: This invention relates to macromolecular complexes useful in drug delivery systems, specifically tri-molecular complexes made between a water-soluble polymer and an acid-insoluble polymer in presence of a bridging molecule. In one aspect, the invention relates to a tri-molecular complex comprising gelatin, acrylic acid/methacrylic acid copolymers, and arginine for use in a soft capsule dosage form. In another aspect, the invention is directed to a tri-molecular complex a hydrophilic, film-forming, water-soluble polymer, a second water-soluble polymer, and a bridging molecule, wherein the second water-soluble polymer is less water-soluble than the hydrophilic, film-forming, water-soluble polymer.Type: ApplicationFiled: November 12, 2008Publication date: October 8, 2009Applicant: Pharmaceutics International, Inc.Inventors: EMADELDIN M. HASSAN, Sridhar Gumudavelli
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Publication number: 20090104236Abstract: The invention provides solid pharmaceutical hybrids that are useful in the treatment or diagnosis of diseases, as well as methods of producing the solid pharmaceutical hybrids.Type: ApplicationFiled: October 18, 2007Publication date: April 23, 2009Applicant: Pharmaceutics International, Inc.Inventor: Emadeldin Hassan