Patents Assigned to Pharmachemie B.V.
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Patent number: 11642475Abstract: This invention provides a budesonide/formoterol dry powder inhaler (10) comprising: a reservoir (14) containing a dry powder medicament and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator (10?) for breaking up agglomerates of the dry powder medicament; a delivery passageway (34) for directing an inhalation-induced air flow through a mouthpiece (24), the delivery passageway extending to the metered dose of medicament, wherein the medicament comprises micronised formoterol fumarate, micronised budesonide and a lactose carrier, the lactose carrier having a particle size distribution of d10=20-65 ?m, d50=80-120 ?m, d90=130-180 ?m and <10 ?m=<10%.Type: GrantFiled: May 28, 2021Date of Patent: May 9, 2023Assignee: PHARMACHEMIE B.V.Inventors: Jan Arp, Johan Keegstra, Michael Imre Goller
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Patent number: 11071835Abstract: Described herein is a dry powder inhaler which includes: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, and an inhalable ?2-agonist having a particle size distribution of d10<1 ?m, d50=1-3 ?m, d90=3.5-6 ?m and NLT 99% 10 ?m and a lactose carrier.Type: GrantFiled: November 19, 2014Date of Patent: July 27, 2021Assignee: PHARMACHEMIE B.V.Inventors: Erwin Van Achthoven, Johan Keegstra, Michael Imre Goller
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Patent number: 11020546Abstract: This invention provides a budesonide/formoterol dry powder inhaler (10) comprising: a reservoir (14) containing a dry powder medicament and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator (10?) for breaking up agglomerates of the dry powder medicament; a delivery passageway (34) for directing an inhalation-induced air flow through a mouthpiece (24), the delivery passageway extending to the metered dose of medicament, wherein the medicament comprises micronised formoterol fumarate, micronised budesonide and a lactose carrier, the lactose carrier having a particle size distribution of d10=20-65 ?m, d50=80-120 ?m, d90=130-180 ?m and <10 um=<10%.Type: GrantFiled: November 19, 2014Date of Patent: June 1, 2021Assignee: Pharmachemie B.V.Inventors: Jan Arp, Johan Keegstra, Michael Imre Goller
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Publication number: 20160303337Abstract: The present invention provides a dry powder inhaler comprising: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; and a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, wherein the formulation comprises an inhalable ?2-agonist having a particle size distribution of d10<1 ?m, d50=1-3 ?m, d90=3.5-6 ?m and NLT 99% 10 ?m and a lactose carrier.Type: ApplicationFiled: November 19, 2014Publication date: October 20, 2016Applicant: PHARMACHEMIE B.V.Inventors: Erwin VAN ACHTHOVEN, Johan KEEGSTRA, Michael Imre GOLLER
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Patent number: 8434477Abstract: An assembly of a tube-shaped body and a tube-shaped cap, which are open at one distal side, is provided to manufacture a capsule for enclosing a medicine. At least one recess is arranged in an outer surface of the body, wherein at least one fixating bulge is arranged in an inner surface of the cap, which is destined to be snugly received in the recess in the outer surface of the body in order to realize a fixed snap connection between the body and the cap. A smallest inner diameter of the fixating bulge of the cap is equal to or smaller than a smallest outer diameter of the recess in the body, which contributes to realizing a fixed snap connection which is firm to such an extent that the capsule is suitable for application in an inhalation apparatus comprising provisions for piercing the capsule at least one place.Type: GrantFiled: December 12, 2007Date of Patent: May 7, 2013Assignee: Pharmachemie B.V.Inventor: Dick De Vos
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Publication number: 20100132705Abstract: An assembly of a tube-shaped body and a tube-shaped cap, which are open at one distal side, is provided to manufacture a capsule for enclosing a medicine. At least one recess is arranged in an outer surface of the body, wherein at least one fixating bulge is arranged in an inner surface of the cap, which is destined to be snugly received in the recess in the outer surface of the body in order to realize a fixed snap connection between the body and the cap. A smallest inner diameter of the fixating bulge of the cap is equal to or smaller than a smallest outer diameter of the recess in the body, which contributes to realizing a fixed snap connection which is firm to such an extent that the capsule is suitable for application in an inhalation apparatus comprising provisions for piercing the capsule at least one place.Type: ApplicationFiled: December 12, 2007Publication date: June 3, 2010Applicant: Pharmachemie B.V.Inventor: Dick De Vos
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Publication number: 20090227617Abstract: The invention relates to novel esters and in particular to some novel esters of glucuronide prodrugs of anthracyclines having tunable water-solubility, their synthesis and use in tumor-selective chemotherapy. It appeared that in the final step in the synthesis of these prodrugs, i.e. the coupling of the glucuronide spacer moiety to the parent drug molecule, protection of the sugar hydroxyls is, surprisingly, no longer required. A process for the preparation of these unprotected sugar spacer moieties is also disclosed.Type: ApplicationFiled: March 6, 2009Publication date: September 10, 2009Applicant: Pharmachemie B.V.Inventors: Rene Wilhelmus Marie Aben, Johan Wilhelm Scheeren, Jeroen Johannes Lambertus Maria Cornelissen, Dick De Vos, Hidde Jacob Haisma
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Patent number: 7430842Abstract: For the prevention of contamination of a vial with traces of medicinal fluids, for example cytostatics and antibiotics, which may be spilt on the outside of the vial while filling, the vial is provided with a tight-fitting protective envelope, preferably made of a transparent synthetic material, as a last step in the production process. Because of this, a possible contamination which remains on the outside of the vial is encapsulated between the vial and the envelope. Hereby, a user is no longer exposed to toxic substances, because the user will not touch the vial itself, but will touch the envelope. An additional advantage of the provision of the envelope is that if breaking of the vial occurs, the envelope will keep the pieces of broken glass together and will possibly prevent the medicinal fluid from leaking away.Type: GrantFiled: December 2, 2004Date of Patent: October 7, 2008Assignee: Pharmachemie B.V.Inventor: Dick De Vos
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Publication number: 20060037287Abstract: For the prevention of contamination of a vial with traces of medicinal fluids, for example cytostatics and antibiotics, which may be spilt on the outside of the vial while filling, the vial is provided with a tight-fitting protective envelope, preferably made of a transparent synthetic material, as a last step in the production process. Because of this, a possible contamination which remains on the outside of the vial is encapsulated between the vial and the envelope. Hereby, a user is no longer exposed to toxic substances, because the user will not touch the vial itself, but will touch the envelope. An additional advantage of the provision of the envelope is that if breaking of the vial occurs, the envelope will keep the pieces of broken glass together and will possibly prevent the medicinal fluid from leaking away.Type: ApplicationFiled: December 2, 2004Publication date: February 23, 2006Applicant: Pharmachemie B.V.Inventor: Dick De Vos
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Patent number: 6613767Abstract: A stable aqueous solution of folinic acid of up to about 400 mg/ml, which does not crystallize at refridgeration temperatures, is obtained by preparing an aqueous solution of sodium folinate.Type: GrantFiled: October 7, 1996Date of Patent: September 2, 2003Assignee: Pharmachemie B.V.Inventors: Alfred James Nijkerk, Johanna M. P. Vermeer
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Patent number: 6407265Abstract: Tin polyaalkanecarboxylates having the formula [(R1pR2qSn)rOs]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P=3, q=1, r=1, s=) and t=1, p=2, q=2, r=1, s=0, and t=1, p=2, q=1, r=2, s=1 and t=2, have anti-tumor activity.Type: GrantFiled: January 29, 2001Date of Patent: June 18, 2002Assignee: Pharmachemie B.V.Inventors: Marcel Gielen, Rudolph Willem, Monique Biesemans, Martine Kemmer, Dick de Vos
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Patent number: 6344571Abstract: The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1=C(O)CH2CH(OH)COOX, R2=H, C(O)CH2CH(OH)COOX, X=H, Li, Na or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical composition comprising an antineoplastically effective amount of such analogs as an active ingredient.Type: GrantFiled: February 21, 2001Date of Patent: February 5, 2002Assignee: Pharmachemie B.V.Inventors: Peter H. G. Wiegerinck, Duncan Sperling, Lesly Braamer, Eric W. P. Damen, Johan W. Scheeren, Dick de Vos
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Patent number: 6225463Abstract: The object of the present invention is the development of new chiral auxiliaries for improved &bgr;-lactam formation that control both the diastereoselectivity of &bgr;-lactam formation and which can be removed without destruction of the sensitive azetidinone ring, providing valuable intermediates for coupling to the C-13 hydroxyl group of anti-tumor taxanes, such as paclitaxel. Further, the object of the present invention is enantiomerically pure (S)-(−)-1-(p-methoxy-phenyl)propyl-1-amine.Type: GrantFiled: December 15, 1998Date of Patent: May 1, 2001Assignees: Pharmachemie B.V., Cancer Research Campaign Technology Ltd.Inventors: Dick de Vos, Stephen Brown, Allan M. Jordan, Nicholas J. Lawrence, Alan Th. McGown
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Patent number: 5874595Abstract: 10-Deacetylbaccatin III is selectively acylated to baccatin III and derivatives thereof in high yield with anhydrides (e.g. acetic anhydride), catalysed by Lewis acids. Extremely effective catalysts in this reaction are compounds of the formula ML.sub.x wherein M is a rare earth metal and L is a anion, preferably a strong electron withdrawing counterion such as triflate.Type: GrantFiled: May 21, 1997Date of Patent: February 23, 1999Assignee: Pharmachemie B.V.Inventors: Eric Wilhelmus Petrus Damen, Johan Wilhelm Scheeren, Dick de Vos
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Patent number: 5874550Abstract: This invention relates to a novel method for the chemical preparation of epirubicin or acid addition salts thereof, in particular the HCl salt, from daunorubicin. This process avoids the disadvantages of the prior art. First daunorubicin is methanolized to obtain daunomycinone and daunosamine methyl ether in very high yields. Daunomycinone is converted to 14-acetoxy daunomycinone by bromination and acetoxylation, while daunosamine methyl ether is converted into an N-protected 4'-epi daunosamine. The choice of the protecting group of the amino group of the daunosamine methyl ether is important because it has to be removed after coupling the sugar with the aglycone without causing side reactions of the aglycone. Two protecting groups were selected: the trifluoroacetyl group and the allyloxycarbonyl group.Type: GrantFiled: December 4, 1997Date of Patent: February 23, 1999Assignee: Pharmachemie B.V.Inventors: Marcel van der Rijst, Johan Wilhelm Scheeren, Dick de Vos
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Patent number: 5765552Abstract: The present invention provides an inhaler device for inhaling an aerosol in a desired dosage, comprising a housing in which is received a reservoir of powder or liquid, an inhaling piece placed on the housing and a mechanism for transporting the powder or liquid from the reservoir to the inhaling piece in a dosage required for the aerosol. A spring biased piston is incorporated into the housing to compress the inhalable medium in the reservoir. The inhalable medium transporting mechanism includes a recess within a reciprocating plunger. The inhaling piece includes two separate air intake openings extending to an exterior of the inhaling piece. The two air intake openings generate separate colliding streams of air which transport and mix the inhalable medium.Type: GrantFiled: May 26, 1995Date of Patent: June 16, 1998Assignees: Pharmachemie B.V., Raytec B.V.Inventors: Pieter Zanen, Adrianus Plomp, Gerhardus Anthonius Boon, Roy van Swieten
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Patent number: 5760072Abstract: A paclitaxel prodrug has a paclitaxel portion coupled to a cleavable N-(aliphatic or aromatic)-O-glycosyl carbamate spacer group, and can be administered orally, topically or by injection to provide an anti-tumor effect, the prodrug being activated by a hydrolizing enzyme, an endogeneous enzyme or an exogeneous enzyme.Type: GrantFiled: September 30, 1996Date of Patent: June 2, 1998Assignee: Pharmachemie B.V.Inventors: Hendricus B. A. de Bont, Ruben G. G. Leenders, Johan W. Scheeren, Hidde J. Haisma, Dick de Vos
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Patent number: 5710135Abstract: Anthracycline derivatives are disclosed which are coupled to an enzymatically cleavable N-phenyl-O-glycosyl carbamate spacer group, which derivatives are represented by the formula ##STR1## as well as the acid addition salts thereof. Further the synthesis of these derivatives and their use, alone or in combination with enzymes or antibody enzyme conjugates are disclosed.Type: GrantFiled: May 24, 1996Date of Patent: January 20, 1998Assignee: Pharmachemie B.V.Inventors: Ruben G. G. Leenders, Eric W. P. Damen, Johan Wilhelm Scheeren, Hidde J. Haisma, Pieter H. J. Houba, Dick De Vos
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Patent number: D667105Type: GrantFiled: May 13, 2011Date of Patent: September 11, 2012Assignee: Pharmachemie B.V.Inventor: Krijn Franciscus Marie Zuyderhoudt
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Patent number: D684254Type: GrantFiled: May 13, 2011Date of Patent: June 11, 2013Assignee: Pharmachemie B.V.Inventor: Krijn Franciscus Marie Zuyderhoudt