Patents Assigned to Pharmacia Corporation (of Pfizer, Inc.)
  • Dual-release compositions of a cyclooxygenase-2 inhibitor
    Patent number: 7220434
    Abstract: Pharmaceutical compositions are provided comprising one or more orally deliverable dose units, each comprising a selective cyclooxygenase-2 inhibitory drug of low water solubility, for example celecoxib, in an immediate-release fraction and a controlled-release, slow-release, programmed-release, timed-release, pulse-release, sustained-release or extended-release fraction. The compositions are useful in treatment or prophylaxis of cyclooxygenase-2 mediated conditions and disorders.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: May 22, 2007
    Assignee: Pharmacia Corporation (of Pfizer, Inc.)
    Inventors: Subhash Desai, Sreekant R. Nadkarni, Randy J. Wald, Gary A. DeBrincat
  • Solid-state form of celecoxib having enhanced bioavailability
    Patent number: 7220867
    Abstract: The selective cyclooxygenase-2 inhibitory drug celecoxib is provided in amorphous form. Also provided is a celecoxib drug substance wherein the celecoxib is present, in at least a detectable amount, as amorphous celecoxib. Also provided is a celecoxib-crystallization inhibitor composite comprising particles of amorphous celecoxib or a celecoxib drug substance of the invention in intimate association with one or more crystallization inhibitors, for example polymers. Also provided is a pharmaceutical composition comprising such a celecoxib-crystallization inhibitor composite and one or more excipients. Also provided are processes for preparing amorphous celecoxib, a celecoxib drug substance of the invention, a celecoxib-crystallization inhibitor composite of the invention, and a pharmaceutical composition of the invention.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: May 22, 2007
    Assignee: Pharmacia Corporation (of Pfizer, Inc.)
    Inventors: Michael J. Hageman, Xiaorong He, Tugrul T. Kararli, Lesley A. MacKin, Patricia J. Miyake, Brian R. Rohrs, Kevin J. Stefanski
  • Processes for preparation of 9,11-epoxy steroids and intermediates useful therein
    Patent number: 7112669
    Abstract: Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.
    Type: Grant
    Filed: February 7, 2005
    Date of Patent: September 26, 2006
    Assignee: Pharmacia Corporation (of Pfizer, Inc.)
    Inventors: John S. Ng, Chin Liu, Dennis K. Anderson, Jon P. Lawson, Joseph J. Wieczorek, Sastry A. Kunda, Leo J. Letendre, Mark J. Pozzo, Yuen-Lung L. Sing, Ping T. Wang, Edward E. Yonan, Richard M. Weier, Thomas R. Kowar, Julio A. Baez, Bernhard Erb
  • Substituted benzopyran derivatives for the treatment of inflammation
    Patent number: 7109211
    Abstract: A class of benzopyran, derivatives is described for use in treating cyclooxygenase-2 mediated disorders. Compounds of particular interest are defined by Formula I? wherein X, A1, A2, A3, A4, R, R?, R1 and R2 are as described in the specification.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: September 19, 2006
    Assignee: Pharmacia Corporation (of Pfizer, Inc.)
    Inventors: Jeffery S Carter, Mark G Obukowicz, Balekudru Devadas, John J Talley, David L Brown, Matthew J Graneto, Stephen R Bertenshaw, Donald J. Rogier, Jr., Srinivasan Raj Nagarajan, Cathleen E Hanau, Susan J Hartmann, Cindy L Ludwig, Suzanne Metz, Donald E Korte
  • Use of propargyl glycine amino propargyl diol compounds for treatment of renal failure
    Patent number: 6777572
    Abstract: Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful for treatment of renal failure.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: August 17, 2004
    Assignee: Pharmacia Corporation (of Pfizer Inc.)
    Inventors: Gunnar J. Hanson, John S. Baran
  • Method and apparatus for dewatering
    Patent number: 5236596
    Abstract: A method and apparatus for dewatering an aqueous coal slurry includes imparting high shear forces to the aqueous coal slurry in the presence of a peptizing agent to render coal particles hydrophobic by stripping clay from the coal particles and peptizing the clay in the aqueous medium of the slurry. The slurry is separating to recover coal particles and the aqueous medium is draining medium from the hydrophobic surface of the coal particles.
    Type: Grant
    Filed: July 24, 1991
    Date of Patent: August 17, 1993
    Inventor: Edward H. Greenwald, Sr.