Patents Assigned to Pharmacia Corporation
  • Method for the preparation of tetrahydrobenzothiepines
    Patent number: 6794544
    Abstract: Among its several embodiments, the present invention provides an improved process for the preparation of tetrahydrobenzothiepine-1,1-dioxide compounds; the provision of a process for preparing a diastereomeric mixture of tetrahydrobenzothiepine-1,1-dioxide compounds from a single diastereomer of such compounds; the provision of a process for the preparation of 3-bromo-2-substituted propionaldehyde compounds; and the provision of a process for the preparation of 3-thio-2-substituted propionaldehyde compounds.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: September 21, 2004
    Assignee: Pharmacia Corporation
    Inventors: Kevin A. Babiak, Andrew Carpenter, Shine Chou, Pierre-Jean Colson, Payman Farid, Robert Hett, Christian H. Huber, Kevin J. Koeller, Jon P. Lawson, James Li, Eduardo K. Mar, Lawrence M. Miller, Vladislav Orlovski, James C. Peterson, Mark J. Pozzo, Claire A. Przybyla, Samuel J. Tremont, Jay S. Trivedi, Grace M. Wagner, Gerald A. Weisenburger, Benxin Zhi
  • Compositions of a cyclooxygenase-2 selective inhibitor and an amphetamine for the treatment of reduced blood flow to the central nervous system
    Publication number: 20040176378
    Abstract: The present invention provides compositions and methods for the treatment of reduced blood flow to the central nervous system in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition comprising the administration to a subject of an amphetamine in combination with a cyclooxygenase-2 selective inhibitor.
    Type: Application
    Filed: February 11, 2004
    Publication date: September 9, 2004
    Applicant: Pharmacia Corporation
    Inventor: Diane T. Stephenson
  • 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6787668
    Abstract: The present invention is directed to a compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of H and methyl; and R2 is selected from the group consisting of H and methyl. The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: September 7, 2004
    Assignee: Pharmacia Corporation
    Inventors: Barnett S. Pitzele, James A. Sikorski, Ronald Keith Webber
  • Polycyclic aryl and heteroaryl substituted 1, 4-quinones useful for selective inhibition of the coagulation cascade
    Publication number: 20040171839
    Abstract: The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: January 7, 2004
    Publication date: September 2, 2004
    Applicant: Pharmacia Corporation
    Inventors: Michael S. South, John J. Parlow
  • Compositions of cyclooxygenase-2 selective inhibitors and selective serotonin reuptake inhibitors for the treatment or prevention of a vaso-occlusive event
    Publication number: 20040171664
    Abstract: The present invention provides compositions and methods for the treatment of a vaso-occlusive event. More particularly, the invention provides a combination therapy for the treatment of a vaso-occlusive event comprising the administration to a subject of a selective serotonin reuptake inhibitor in combination with a cyclooxygenase-2 selective inhibitor.
    Type: Application
    Filed: December 22, 2003
    Publication date: September 2, 2004
    Applicant: Pharmacia Corporation
    Inventors: Diane T. Stephenson, Duncan P. Taylor
  • Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade
    Publication number: 20040162319
    Abstract: The invention relates to polycyclic aryl and heteroaryl substituted 4-pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: February 2, 2004
    Publication date: August 19, 2004
    Applicant: Pharmacia Corporation
    Inventors: Michael S. South, Chun C. Ma, Kevin J. Koeller, Hayat K. Rahman, William L. Neumann
  • Use of propargyl glycine amino propargyl diol compounds for treatment of renal failure
    Patent number: 6777572
    Abstract: Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful for treatment of renal failure.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: August 17, 2004
    Assignee: Pharmacia Corporation (of Pfizer Inc.)
    Inventors: Gunnar J. Hanson, John S. Baran
  • Methods and compositions for the treatment of herpes virus infections using cyclooxygenase-2 selective inhibitors or cyclooxygenase-2 inhibitors in combination with antiviral agents
    Publication number: 20040157848
    Abstract: The present invention provides compositions and methods for the treatment of herpes virus infections. In one aspect, the invention provides a combination therapy for treating a herpes virus infection comprising the administration to a subject of an anti-herpes virus agent in combination with a cyclooxygenase-2 selective inhibitor. In another aspect, the invention provides a mono therapy for treating a herpes virus infection comprising administering a cyclooxygenase-2 selective inhibitor to a subject.
    Type: Application
    Filed: December 19, 2003
    Publication date: August 12, 2004
    Applicant: Pharmacia Corporation
    Inventor: Timothy Maziasz
  • Pyrrolo[1,2-b][1,2,4]oxadiazine diones useful as nitric oxide synthase inhibitors
    Patent number: 6774126
    Abstract: Pyrrolo[1,2-b][1,2,4]oxadiazine-2,3(6H)-diones having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: August 10, 2004
    Assignee: Pharmacia Corporation
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Alok K. Awasthi, Suzanne Metz, Jeffrey A. Scholten, Jeffery S. Snyder, Mihaly V. Toth, Ronald Keith Webber
  • Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
    Publication number: 20040152739
    Abstract: Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNF&agr;, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
    Type: Application
    Filed: December 19, 2003
    Publication date: August 5, 2004
    Applicant: Pharmacia Corporation
    Inventors: Cathleen E. Hanau, Serena Marie Mershon, Matthew J. Graneto, Marvin J. Meyers, Shridhar G. Hegde, Ingrid P. Buchler, Kun K. Wu, Shuang Liu, Kassoum Nacro
  • Protease inhibitors of the coagulation cascade isolated from Dysidea sponges
    Publication number: 20040147456
    Abstract: The present invention is directed toward a composition comprising a compound isolated from Dysidea species sponges that is capable of inhibiting serine proteases of the coagulation cascade. In particular, this composition inhibits the TF/VIIa complex of the coagulation cascade. The invention is also directed toward methods employing this composition as a part of anticoagulant therapy.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 29, 2004
    Applicant: Pharmacia Corporation
    Inventors: Gilles H. Goetz, George G. Harrigan, John J. Likos, Thomas P. Kasten
  • Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
    Publication number: 20040147581
    Abstract: Compositions and methods to treat or prevent pain, inflammation, or inflammation-related disorder, as well as a neurologic disorder involving neurodegrneration in a subject that is in need of such prevention or treatment involve a combination of a Cox-2 inhibitor and a 5-HT1A receptor modulator.
    Type: Application
    Filed: November 5, 2003
    Publication date: July 29, 2004
    Applicant: Pharmacia Corporation
    Inventors: Duncan P. Taylor, Diane T. Stephenson
  • Combinations of superoxide dismutase mimetics and nonsteroidal analgesic / anti-inflammatory drugs
    Publication number: 20040147498
    Abstract: Combinations of synthetic low molecular weight catalysts for the dismutation of superoxide and Nonsteroidal Analgesic/Anti-Inflammatory Drugs (NSAIDs) are potent analgesics that are effective in elevating the pain threshold in hyperalgesic conditions.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 29, 2004
    Applicants: MetaPhore Pharmaceuticals, Inc., Pharmacia Corporation
    Inventor: Daniela Salvemini
  • Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase-2
    Publication number: 20040142978
    Abstract: Aminocyanopyridine compounds are described which can inhibit mitogen activated protein kinase-activated protein kinase-2. Pharmaceutical compositions and kits that contain these compounds are also described.
    Type: Application
    Filed: December 5, 2003
    Publication date: July 22, 2004
    Applicant: Pharmacia Corporation
    Inventors: David R. Anderson, Nathan W. Stehle, Stephen A. Kolodziej, Emily J. Reinhard, Len F. Lee
  • Amyloid immunization and Cox-2 inhibitors for the treatment of alzheimer's disease
    Publication number: 20040138296
    Abstract: The present invention provides compositions and methods for the treatment or prevention of Alzheimer's disease. More particularly, the invention provides a combination therapy for the treatment or prevention of Alzheimer's disease, wherein the therapy comprises administering to a subject an amyloid beta vaccine in combination with a cyclooxygenase-2 selective inhibitor.
    Type: Application
    Filed: July 25, 2003
    Publication date: July 15, 2004
    Applicant: Pharmacia Corporation
    Inventors: David W. Robertson, Grant A. Krafft
  • Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
    Publication number: 20040138261
    Abstract: Methods of treating cyclooxygenase-2 mediated disorders comprising administering to a subject a therapeutically effective amount of one or more fluoro-substituted benzenesulfonyl compounds corresponding to Formula I: 1
    Type: Application
    Filed: December 12, 2003
    Publication date: July 15, 2004
    Applicant: Pharmacia Corporation
    Inventors: David L. Brown, Matthew J. Graneto, Cindy L. Ludwig, John M. Molyneaux, John J. Talley
  • Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
    Publication number: 20040138275
    Abstract: The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Application
    Filed: November 12, 2003
    Publication date: July 15, 2004
    Applicant: Pharmacia Corporation
    Inventors: Michael S. South, John J. Parlow
  • Method of making tricyclic aminocyanopyridine compounds
    Publication number: 20040127714
    Abstract: A method of making aminocyanopyridine compounds which are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 is described.
    Type: Application
    Filed: December 5, 2003
    Publication date: July 1, 2004
    Applicant: Pharmacia Corporation
    Inventors: David R. Anderson, Shridhar G. Hegde, Stephen A. Kolodziej, William F. Vernier, Emily J. Reinhard
  • Antiangiogenic combination therapy for the treatment of cancer
    Publication number: 20040127539
    Abstract: The present invention provides combinations of a DNA topoisomerase I inhibiting agent and a selective Cox-2 inhibiting agent for preventing, treating, and/or reducing the risk of developing a neoplasia disorder in a mammal.
    Type: Application
    Filed: October 24, 2003
    Publication date: July 1, 2004
    Applicant: Pharmacia Corporation
    Inventor: Jaime L. Masferrer
  • Methods and compositions for the prevention or treatment of neoplasia comprising a Cox-2 inhibitor in combination with an epidermal growth factor receptor antagonist
    Publication number: 20040127470
    Abstract: The present invention relates to a novel method of preventing and/or treating neoplasia disorders in a subject that is in need of such prevention or treatment by administering to the subject at least one Cox-2 inhibitor in combination with an EGF receptor antagonist. Compositions, pharmaceutical compositions and kits are also described.
    Type: Application
    Filed: August 29, 2003
    Publication date: July 1, 2004
    Applicant: Pharmacia Corporation
    Inventor: Jaime Masferrer