Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
Type:
Application
Filed:
March 16, 2004
Publication date:
May 5, 2005
Applicant:
Pharmacia & Upjohn Company, a Delaware corporation
Inventors:
Riqiang Yan, Alfredo Tomasselli, Mark Gurney, Thomas Emmons, Michael Bienkowski, Robert Heinrikson
Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
Type:
Application
Filed:
March 16, 2004
Publication date:
December 16, 2004
Applicant:
Pharmacia & Upjohn Company, a Delaware corporation
Inventors:
Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
Type:
Application
Filed:
March 16, 2004
Publication date:
December 16, 2004
Applicant:
Pharmacia & Upjohn Company, a Delaware corporation
Inventors:
Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
Type:
Application
Filed:
March 16, 2004
Publication date:
December 16, 2004
Applicant:
Pharmacia & Upjohn Company, a Delaware corporation
Inventors:
Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a &bgr;-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
Type:
Application
Filed:
March 16, 2004
Publication date:
December 2, 2004
Applicant:
Pharmacia & Upjohn Company, a Delaware corporation
Inventors:
Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson