Patents Assigned to Pharmacia & Upjohn Company
  • Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
    Publication number: 20040215017
    Abstract: Substituted quinolone derivatives in which an oxazolidinone, isoxazolinone, or isoxazoline is covalently bonded to a quinolone, methods of using the quinolone derivatives, and pharmaceutical compositions containing the quinolone derivatives are disclosed. Methods of synthesizing these substituted quinolone derivatives are also disclosed, and in particular a method of manufacturing a 7-(2-oxo-1,3-oxazolidin-3-yl)aryl-3-quinolinecarboxylic acid by condensing a 4-(2-oxo-1,3-oxazolidin-5-yl)aryl boronic acid with a 7-halo-quinolone derivative. The quinolone derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.
    Type: Application
    Filed: December 5, 2003
    Publication date: October 28, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Mikhail F. Gordeev, Dinesh V. Patel, Michael R. Barbachyn, James R. Gage
  • Method of treating sexual disturbances
    Publication number: 20040214825
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) 1
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventors: Robert B. McCall, Martin Durham Meglasson
  • Method of treating sexual disturbances
    Publication number: 20040214826
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) 1
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventors: Robert M. McCall, Martin Durham Meglasson
  • Method of treating sexual disturbances
    Publication number: 20040214824
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) 1
    Type: Application
    Filed: May 24, 2004
    Publication date: October 28, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventors: Robert B. McCall, Martin Durham Meglasson
  • Method of treating sexual disturbances
    Publication number: 20040214823
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) 1
    Type: Application
    Filed: May 14, 2004
    Publication date: October 28, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventors: Robert B. McCall, Martin Durham Meglasson
  • Method of treating sexual disturbances
    Patent number: 6809112
    Abstract: The present invention is a method of treating sexual disturbances in humans and inducing mating in non-human mammals using the compounds of formula (A) in a dosage range where the sexually therapeutic amount is from about 0.2 thru 8 mg/person/dose and where the sexually mating amount is from about 0.003 thru 0.2 mg/kg/dose.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: October 26, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Robert B. McCall, Martin Durham Meglasson
  • Substituted ureas and carbamates
    Publication number: 20040209925
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: November 26, 2003
    Publication date: October 21, 2004
    Applicants: ELAN PHARMACEUTICALS, INC., PHARMACIA & UPJOHN COMPANY
    Inventors: Shon R. Pulley, John A. Tucker
  • Container for linezolid intravenous solution
    Patent number: 6796975
    Abstract: The present invention is a container for an IV aqueous solution of a Gram-positive oxazolidinone agent, such as linezolid a the compound of formula: which comprises having the container-solution contact surface material be a polyolefin.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Sandra M. Sims, Phil Bryan Bowman, Daniel C. Wade, Shri C. Valvani
  • Aspheric soft lens
    Patent number: 6797003
    Abstract: An aspheric soft intraocular lens, having an optical power surface, which may have multiple radii portions or aspherical portions, as well as spherical portions, intended to replace the crystalline lens of a patient's eye, in particular after a cataract extraction. Such an aspheric soft lens is molded in a coined mold. A pair of core pins, positioned within the mold cavity during the lens forming process, will produce a pair of haptic-mounting holes within the lens. As the lenses are subsequently tumbled to remove flash, indentations will form adjacent to the haptic-mounting holes. These indentations allow for tangential attachment of the haptic to the lens which, in turn, enables maximum flexibility without exceeding the width of the optic.
    Type: Grant
    Filed: December 1, 1993
    Date of Patent: September 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Larry W. Blake, Lee T. Nordan
  • Phosphoric acid isomerization of A 5 (10), 9 (11)—diene steroid to the corresponding 4, 9-diene steroid
    Patent number: 6797834
    Abstract: The invention is a process for the preparation of a &Dgr;4,9-steroid of formula (II) which comprises contacting a &Dgr;5(10),9(11)-steroid of formula (I) with a phosphorous containing acid.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: September 28, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventor: Rajappa Vaidyanathan
  • Anti-bacterial vaccine compositions
    Patent number: 6790950
    Abstract: Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: September 14, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: David E. Lowery, Troy E. Fuller, Michael J. Kennedy
  • Alzheimer's disease, secretase, APP substrates therefor, and uses therefor
    Patent number: 6790610
    Abstract: The present invention provides the enzyme and enzymatic procedures for cleaving the &bgr; secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell isolates and assays. The invention further provides a modified APP protein and associated nucleic acids, peptides, vectors, cells, and cell isolates, and assays that are particularly useful for identifying candidate therapeutics for treatment or prevention of Alzheimer's disease.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: September 14, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mark E. Gurney, Michael J. Bienkowski, Robert L. Heinrikson, Luis A. Parodi, Riqiang Yan
  • Crystallization and structure determination of staphylococcus aureus thymidylate kinase
    Publication number: 20040171050
    Abstract: An unliganded form of Staphylococcus aureus thymidylate kinase (S. aureus TMK) has been crystallized, and the three dimensional x-ray crystal structure has been solved to 2.3 Å resolution. The x-ray crystal structure is useful for solving the structure of other molecules or molecular complexes, and designing inhibitors of S. aureus TMK activity.
    Type: Application
    Filed: January 8, 2004
    Publication date: September 2, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventor: Timothy E. Benson
  • Arylsulphonyl substituted-tetrahydro-and hexahydro-carbazoles
    Publication number: 20040162332
    Abstract: The invention provides compounds of formula I for use in treating conditions in which 5-HT6 receptors are involved such as in anxiety, depression, schizophrenia, Alzheimer's disease, stress-related disease, panic, a phobia, obsessive compulsive disorder, obesity, post-traumatic stress syndrome, epilepsy, and other CNS disorders.
    Type: Application
    Filed: February 12, 2004
    Publication date: August 19, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventor: Jian-Min Fu
  • Therapeutic 5-HT ligand compounds
    Publication number: 20040157831
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: February 3, 2004
    Publication date: August 12, 2004
    Applicant: Pharmacia & Upjohn Company
    Inventor: William W. McWhorter
  • Method for the preparation of oxazolidinones
    Patent number: 6774231
    Abstract: The present invention relates to a process for making a compound of structure 4 which comprises reacting a compound of structure 1 with vinyl sulfone in the presence of a Lewis-acid at a temperature in a range of from 40° C. to 170° C., wherein each R1 is independently H, fluoro, chloro or bromo.
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: August 10, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Jiong Jack Chen, Cuong V. Lu
  • Novel component in the hedgehog signalling pathway
    Publication number: 20040146929
    Abstract: The present invention relates to a novel human patched-like gene (PTCH2), which for the first time has been cloned and sequenced. Several alternatively spliced mRNA forms of PTCH2 have been identified, including transcripts lacking segments thought to be involved in sonic hedgehog (SHH) binding and mRNAs with differentially defined 3′ terminal exons. Further, the invention also relates to the protein encoded by the present PTCH2 as well as to functional analogues and variants thereof.
    Type: Application
    Filed: March 4, 2004
    Publication date: July 29, 2004
    Applicant: Karolinska Innovations AB and Pharmacia & Upjohn Company
    Inventors: Peter G. Zaphiropoulos, Anne Birgitte Unden, Rune Toftgard, Fahimeh Rahnama, Robert E. Hollingsworth
  • Method of treating or preventing peripheral neuropathy with a highly selective norepinephrine reuptake inhibitor
    Publication number: 20040147614
    Abstract: Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Application
    Filed: January 16, 2004
    Publication date: July 29, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Erik H.F. Wong, Saeeduddin Ahmed, Robert Clyde Marshall, Robert McArthur, Duncan P. Taylor
  • Methods of producing oxazolidinone compounds
    Publication number: 20040143131
    Abstract: Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 22, 2004
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: William R. Perrault, Robert C. Gadwood
  • Antimicrobial methods and materials
    Patent number: 6764823
    Abstract: The present invention provides methods of identifying antimicrobial agents that target genes essential for the survival of Staphylococcus bacteria, including antimicrobial agents that interfere with the expression of essential coding sequence products and antimicrobial agents that interfere with the function of essential coding sequence products.
    Type: Grant
    Filed: April 6, 2001
    Date of Patent: July 20, 2004
    Assignee: Pharmacia & Upjohn Company
    Inventors: Che-Shen C. Tomichi, Cheryl Quinn, Staffan Arvidson