Patents Assigned to Pharmacia & Upjohn
  • Process for preparing oxazole intermediates
    Patent number: 7115747
    Abstract: Disclosed are compounds of formula III and a process to prepare a compound of formula III wherein R1, R2, R3 and R6 are defined herein, using a zinc chloride/optionally substituted oxazole adduct and an compound of formula I. Further disclosed are methods of using compounds of formula III to prepare compounds useful in the treatment of Alzheimer's disease and related conditions.
    Type: Grant
    Filed: June 20, 2003
    Date of Patent: October 3, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael R. Reeder, Rick J. Imbordino
  • Tablet formation
    Patent number: 7108864
    Abstract: Disclosed is a non-sustained release pharmaceutical tablet composition which comprises a rapidly precipitating drug in an amount from about 5 to about 60% and at least one member selected from the group consisting of a binder in an amount of from about 2 to about 25% and a superdisintegrant in an amount from about 6 to about 40% where the rapidly precipitating drug, “binder” and superdisintegrant are mixed and compressed into a tablet without heating, solvent or grinding.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: September 19, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Alice C. Martino, Ashley H. Bates, Walter Morozowich, E. John Lee
  • Antimicrobial 1-aryl dihydropyridone compounds
    Patent number: 7105547
    Abstract: The present invention provides antibacterial agents of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: September 12, 2006
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mikhail Fedor Gordeev, Upinder Singh, Dinesh Vinoobhai Patel, Paul Dennis May
  • Oral liquid tolterodine composition
    Patent number: 7101888
    Abstract: A pharmaceutical composition in a form of an orally deliverable liquid comprises water having in solution therein a pharmaceutically acceptable water-soluble salt of a tolterodine related compound at a therapeutically effective concentration in the composition. The composition has a pH of about 2 to about 6 and further comprises a sweetening agent and an antimicrobial agent at a concentration that is antimicrobially effective at the pH of the composition. The composition is useful for treating a muscarinic receptor mediated disorder, more particularly overactive bladder, in a subject by orally administering to the subject a therapeutically effective amount of the composition.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: September 5, 2006
    Assignee: Pharmacia & UpJohn Company
    Inventors: Joseph P. Reo, Kathryn M. Kienle, Jennifer K. Fredrickson
  • Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
    Patent number: 7101874
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein Y is —S(?O)n—, —S(?NR8)—, or —S(?NR8)(?O)—; Z is —NHC(?O)R1, —NHC(?S)R1, —NH-het1, —O-het1, —S-het1, or -het2. The compounds of formula I are useful as antibacterial agents.
    Type: Grant
    Filed: February 22, 2005
    Date of Patent: September 5, 2006
    Assignee: Pharmacia and Upjohn Company
    Inventors: Mikhail F. Gordeev, Adam Renslo, Gary W. Luehr, Stuart Lam, Neil E. Westlund, Dinesh Vinoobhai Patel
  • Substituted aminoethers for the treatment of alzheimer's disease
    Publication number: 20060194966
    Abstract: The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Application
    Filed: September 10, 2003
    Publication date: August 31, 2006
    Applicant: Pharmacia & Upjohn Company LLC
    Inventors: James Beck, Matthew Drowns, Martha Warpehoski
  • N-Aryl-2-oxazolidinones and their derivatives
    Patent number: 7094900
    Abstract: The present invention provides antibacterial agents of formula I described herein.
    Type: Grant
    Filed: August 1, 2003
    Date of Patent: August 22, 2006
    Assignee: Pharmacia & Upjohn Company LLC
    Inventors: Robert C. Gadwood, Jason M. Ochoada
  • Process to prepare oxazolidinones
    Patent number: 7087784
    Abstract: The present invention relates to a one-step process to prepare pharmacologically active 2-oxo-5-oxazolidinylmethylacetamides.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: August 8, 2006
    Assignee: Pharmacia & Upjohn
    Inventors: William R. Perrault, Bruce Allen Pearlman, Delara B. Godrej
  • Heterocyclic amines having central nervous system activity
    Patent number: 7074927
    Abstract: Tricyclic nitrogen containing compounds, having anxiolytic and anti-depressant activity and central nervous system activity of the following structural formula: and pharmaceutically acceptable salts thereof wherein R1 and R2 are independently hydrogen, C1-6 alkyl or R1 and R2 are joined to form pyrrolidine, piperidine, morpholine or imidazole. X is OCH3, SO2R3, SO2CF3 or CN where R3 is C1-6 alkyl or an Aryl; and Y is hydrogen, Cl, Br, F, CN, CONR1R2, CF3, OCH3, SO2NR1R2. These new compounds are suitable for treating anxiolytic disorder, schizophrenia, Parkinson's disease, anxiety, depression or as compounds for lowering blood pressure or treating migraine headaches in patients in need of such treatment.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: July 11, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventor: Arthur G. Romero
  • Substituted peptides useful in the treatment of alzheimer's disease
    Publication number: 20060148803
    Abstract: Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I), wherein Ar, W, Z, Q, R1, U, and L, are as herein defined.
    Type: Application
    Filed: October 21, 2003
    Publication date: July 6, 2006
    Applicant: Pharmacia & Upjohn Company LLC
    Inventor: James Beck
  • Anthelmintic and insecticidal compositions
    Patent number: 7071215
    Abstract: Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: July 4, 2006
    Assignee: Pharmacia & Upjohn Company LLC
    Inventor: Byung Hyun Lee
  • METHOD OF TREATING MIGRAINE HEADACHES
    Publication number: 20060142289
    Abstract: Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 29, 2006
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Erik Wong, Saeeduddin Ahmed, Robert Marshall, Robert McArthur, Duncan Taylor
  • Diaminediols for the treatment of Alzheimer's disease
    Patent number: 7067542
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert A. Chrusciel
  • Human ion channel proteins
    Patent number: 7067626
    Abstract: The present invention provides novel ion channel polypeptides and polynucleotides that identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The invention also provides methods for the identification of ion channel agonists/antagonists, useful for the treatment of human diseases and conditions.
    Type: Grant
    Filed: July 5, 2001
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Christopher W. Benjamin, Steven L. Roberds, Alla M. Karnovsky, Cara L. Ruble
  • Macrocycles useful in the treatment of Alzheimer's disease
    Patent number: 7067507
    Abstract: The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: June 27, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Shon R. Pulley, James P. Beck, Ruth E. TenBrink, Jon S. Jacobs
  • Method of treating peripheral neuropathy
    Publication number: 20060135520
    Abstract: Methods and compositions for treating humans suffering from or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 22, 2006
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Erik Wong, Saeeduddin Ahmed, Robert Marshall, Robert McArthur, Duncan Taylor
  • METHOD OF TREATING CHRONIC FATIGUE SYNDROME
    Publication number: 20060135521
    Abstract: Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 22, 2006
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Erik Wong, Saeeduddin Ahmed, Robert Marshall, Robert McArthur, Duncan Taylor
  • Method of treating chronic fatigue syndrome
    Publication number: 20060128705
    Abstract: Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a compound having a pharmacological selectivity of serotonin (Ki)/norepinephrine (Ki) of at least about 5000. Examples of such compounds include reboxetine, and more preferably optically pure (S,S) enantiomer of reboxetine. The methods generally include administration of a therapeutic amount of such compositions. Also disclosed are preparations of a medicament from the composition, and uses of the composition in a manufacture of the medicament to treat a human suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or condition.
    Type: Application
    Filed: February 7, 2006
    Publication date: June 15, 2006
    Applicant: PHARMACIA & UPJOHN COMPANY
    Inventors: Erik Wong, Saeeduddin Ahmed, Robert Marshall, Robert McArthur, Duncan Taylor
  • Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives
    Patent number: 7053113
    Abstract: The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
    Type: Grant
    Filed: December 24, 2003
    Date of Patent: May 30, 2006
    Assignees: Sugen, Inc., Pharmacia & Upjohn Company LLC
    Inventors: Malcolm Wilson Moon, Walter Morozowich, Ping Gao, Peng Cho Tang
  • Aminediols for the treatment of Alzheimer's disease
    Patent number: 7053109
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: May 30, 2006
    Assignee: Pharmacia & Upjohn Company
    Inventors: Heinrich Josef Schostarez, Robert Alan Chrusciel