Abstract: A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard unmodified protein, colloid or crystalloid and a fluorescently-labeled protein, colloid or crystalloid of approximately the same molecular weight. The use of blood volume expanders to measure, adjust and maintain the level of blood volume in a patient also is described.
Type:
Application
Filed:
April 30, 2021
Publication date:
December 9, 2021
Applicant:
PharmacoPhotonics, Inc. d/b/a FAST BioMedical
Inventors:
Ruben Sandoval, JR., Erinn Sheridan Reilly, Daniel Meier
Abstract: A method and system for selecting a treatment for a subject based on a value for the interstitial space volume of the subject utilizes plurality of sample data values representing concentrations of small and large markers in plurality of blood samples over time. The sample concentrations are utilized to predict a hypothetical peak concentration of the small marker prior to the dissipation of the markers during the test period. This hypothetical peak concentration and other sample values are utilized with either a bi-exponential or tri-exponential decay curve fitting algorithm to define a decay curve, the curve characteristics of which are then utilized to calculate values for glomerular filtration rate, a leakage rate of the small marker into interstitial space, and finally a value for the interstitial volume. The determined value for the interstitial volume can then be compared with number thresholds and decisions made for recommended therapy for the subject, if desired.
Type:
Application
Filed:
October 7, 2019
Publication date:
June 4, 2020
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL
Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
Type:
Application
Filed:
December 6, 2019
Publication date:
April 9, 2020
Applicant:
PharmacoPhotonics, Inc. d/b/a FAST BioMedical
Inventors:
Ulf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Type:
Application
Filed:
November 22, 2019
Publication date:
April 2, 2020
Applicant:
PharmacoPhotonics, Inc. d/b/a FAST BioMedical
Inventors:
Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
Abstract: Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.
Type:
Application
Filed:
June 24, 2016
Publication date:
June 28, 2018
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL
Inventors:
Daniel J. Meier, Ruben M. Sandoval, Jr., Erinn Reilly