Patents Assigned to Pharmacopiea, Inc.
  • Fluorescent capture assay for kinase activity
    Publication number: 20020177179
    Abstract: A method for determining the level of tyrosine kinase activity in a biological sample is disclosed. The method employs an anti-phosphotyrosine antibody as both the capture agent and the detecting agent. The detecting antibody is labeled with a fluorescent label, for instance, Cy5, Cy5.5 or Cy7 or a lanthanide ion, such as europium, as the signal generating entity. The method is particularly well suited to high throughput screening, for example, for compounds which modulate tyrosine kinase activity.
    Type: Application
    Filed: April 18, 2002
    Publication date: November 28, 2002
    Applicant: Pharmacopiea, Inc.
    Inventors: J. Fraser Glickman, James Inglese, Bassam Damaj, Maria L. Webb, Jonathan J. Burbaum