Patents Assigned to Pharmacore, Inc.
-
Patent number: 7507830Abstract: Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.Type: GrantFiled: September 23, 2004Date of Patent: March 24, 2009Assignee: Pharmacore, Inc.Inventor: Joseph A. Miller
-
Patent number: 7105467Abstract: The present invention provides nickel catalysts and solvents which are useful in a cross-coupling reaction between an organomagnesium compound and an aromatic ether compound, such as an anisole derivative.Type: GrantFiled: July 8, 2003Date of Patent: September 12, 2006Assignee: Pharmacore, Inc.Inventor: John W. Dankwardt
-
Patent number: 7105707Abstract: Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.Type: GrantFiled: December 17, 2003Date of Patent: September 12, 2006Assignee: PharmaCore, Inc.Inventors: Joseph A. Miller, Jonathan M. Penney
-
Patent number: 6962999Abstract: Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.Type: GrantFiled: July 23, 2002Date of Patent: November 8, 2005Assignee: Pharmacore, Inc.Inventor: Joseph A. Miller
-
Patent number: 6930200Abstract: Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3)CO(OR1).Type: GrantFiled: June 26, 2003Date of Patent: August 16, 2005Assignee: Pharmacore, Inc.Inventor: Adnan M. M. Mjalli
-
Patent number: 6809207Abstract: The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, or thienyl group. The present invention further provides a method for synthesizing alpha-amino acids and derivatives thereof via a modified Ugi type reaction using an aldehyde, ammonium formate and a C1-C5 alkyl isocyanide. The compounds provided by this method are useful in the development of new pharmaceuticals for the treatment of human diseases.Type: GrantFiled: July 24, 2002Date of Patent: October 26, 2004Assignee: PharmaCore, Inc.Inventors: Sekar Alla, Seung-Yong Choi, Dale Dhanoa, Elso DiFranco, Galina Krokhina, Keqiang Li, Balasubramanian Thiagarajan, Wen-Chun Zhang
-
Patent number: 6713580Abstract: The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be linked to solid supports. These templates make possible the production of novel classes of chemical compounds through a plurality of chemical reactions. The templates are advantageous for use in drug discovery regimes.Type: GrantFiled: December 6, 2001Date of Patent: March 30, 2004Assignee: Pharmacore, Inc.Inventors: Michael Johnson, Keqiang Li, Elso DiFranco, Daljit S. Dhanoa
-
Patent number: 6677367Abstract: A compound selected from the group consisting of a compound of formula I a compound of formula II and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.Type: GrantFiled: October 24, 2002Date of Patent: January 13, 2004Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Gervais Bérubé, Patrick Soucy, Yongsen Zhao, Jocelyn Yelle
-
Patent number: 6656965Abstract: A compound selected from the group consisting of a compound of formula I a compound of formula II and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.Type: GrantFiled: September 17, 2002Date of Patent: December 2, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Gervais Bérubé, Patrick Soucy, Yongsen Zhao, Jocelyn Yelle
-
Patent number: 6638921Abstract: A compound of formula I and pharmaceutically acceptable derivatives thereof Cx, R1 and R2 being as defined in the disclosure may be used to inhibit the activity of HIV integrase.Type: GrantFiled: June 28, 2002Date of Patent: October 28, 2003Assignee: Pharmacor Inc.Inventors: Gilles Sauvé, Brent Richard Stranix
-
Patent number: 6632816Abstract: The present invention provides HIV aspartyl protease inhibitors of the formula; and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, wherein R1 may be, for example, iso-butyl, wherein X and Y, same or different, may be, for example, NH2 and F, and wherein R2 and R3 are as defined herein.Type: GrantFiled: December 23, 2002Date of Patent: October 14, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Jean-François Lavallée, Nicolas LeBerre, Valérie Perron
-
Patent number: 6610689Abstract: A compound selected from the group consisting of a compound of formula I a compound of formula II and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.Type: GrantFiled: September 17, 2002Date of Patent: August 26, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Gervais Bérubé, Patrick Soucy, Yongsen Zhao, Jocelyn Yelle
-
Patent number: 6608100Abstract: A compound selected from the group consisting of a compound of formula I a compound of formula II and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.Type: GrantFiled: September 17, 2002Date of Patent: August 19, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Gervais Bérubé, Patrick Soucy, Yongsen Zhao, Jocelyn Yelle
-
Patent number: 6528532Abstract: The present invention provides HIV aspartyl protease inhibitors of the formula: and when the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein n is 3 or 4, Y is O, S, NH or N—CN, wherein Cx may be, for example COOH, or CH2OH, wherein R1 is selected from the group consisting of a benzenesulfonyl group of formula II as defined herein, wherein R2 may be, for example, iso-butyl, or 3-methylbutyl, and wherein R3 and R4 are as defined herein.Type: GrantFiled: May 13, 2002Date of Patent: March 4, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Abderrahim Bouzide, Gilles Sauvé
-
Patent number: 6528655Abstract: A compound of formula I′ and pharmaceutically acceptable derivatives thereof including, for example, where applicable or appropriate pharmaceutically acceptable salts thereof. Ar and Ar′ are aromatic or aryl type groups. The compounds have HIV integrase inhibitory properties. Ar, Ar′ and W may be as defined in the specification.Type: GrantFiled: September 26, 2001Date of Patent: March 4, 2003Assignee: Pharmacor, Inc.Inventors: Blaise Magloire N'Zemba, Gilles Sauvé, Guy Sévigny, Jocelyn Yelle
-
Patent number: 6506786Abstract: A compound selected from the group consisting of a compound of formula I a compound of formula II and when the compound of formula I and II comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein R1, R2, Cx, n, R3, R4, R5, Y are as defined in the specification.Type: GrantFiled: February 13, 2001Date of Patent: January 14, 2003Assignee: Pharmacor Inc.Inventors: Brent Richard Stranix, Gilles Sauvé, Abderrahim Bouzide, Alexandre Coté, Gervais Bérubé, Patrick Soucy, Yongsen Zhao, Jocelyn Yelle
-
Patent number: 6455587Abstract: The present invention relates to a class of amino acid derivatives with HIV aspartyl protease inhibitory properties.Type: GrantFiled: March 15, 2000Date of Patent: September 24, 2002Assignee: Pharmacor Inc.Inventors: Abderrahim Bouzide, Gilles Sauvé, Brent Richard Stranix, Guy Sévigny, Jocelyn Yelle
-
Patent number: 6362165Abstract: An hydroxyphenyl derivative selected from the group consisting of a compound of formula and when a compound of formula I comprises a carboxylic acid group pharmaceutically acceptable salts thereof and when a compound of formula I comprises an amino group pharmaceutically acceptable ammonium salts thereof, wherein n is 1, 2 or 3, e is 1, 2 or 3, Hal represents a halogen atom (e.g. Cl, Br, F or I), p is 0, 1 or 2, r is 0, 1 or 2, X and X′ each independently represents a single bond, a saturated straight or branched hydrocarbon group of 1 to 4 carbon atoms or a straight or branched hydrocarbon group of 2 to 4 carbon atoms comprising a carbon to carbon double bond, Ra represents H or —CH3, and Raa represents H or —CH3; W may represent an amino acid residue or fragment. These compounds may be used to inhibit the activity of HIV integrase.Type: GrantFiled: March 27, 2000Date of Patent: March 26, 2002Assignee: Pharmacor Inc.Inventors: Gilles Sauvé, Jocelyn Yelle
-
Patent number: 6313177Abstract: A D-mannitol derivative selected from the group consisting of a compound of formula pharmaceutically acceptable derivatives thereof and where applicable or appropriate pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are the same or different and may each independently be selected from among alkyl and aryl (i.e. aromatic including aromatic like) groups. The D-mannitol derivatives may be used as HIV aspartyl protease inhibitors.Type: GrantFiled: April 30, 1999Date of Patent: November 6, 2001Assignee: Pharmacor Inc.Inventors: Gilles Sauvé, Abderrahim Bouzide