Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
Type:
Grant
Filed:
July 8, 2015
Date of Patent:
January 31, 2017
Assignee:
Pharmacylics LLC
Inventors:
Lee Honigberg, Erik Verner, Joseph J. Buggy, David Loury, Wei Chen