Abstract: A composition for transdermal and dermal administration of interferon-&agr; is described. The composition is comprised of lipid vesicles including a fatty acylated amino acid and an oil-in-water emulsion. Interferon-&agr; is entrapped in the vesicles.
Abstract: A composition for transdermal administration of a cytokine is described. The composition includes a conjugate composed of a cytokine, such as an interferon, and at least one fatty acid moiety covalently attached to the cytokine. The conjugate has enhanced cutaneous delivery relative to the cytokine alone.
Type:
Grant
Filed:
December 4, 2000
Date of Patent:
September 3, 2002
Assignee:
PharmaDerm Laboratories, Ltd.
Inventors:
Marianna Foldvari, Sam Kwadwo Attah-Poku
Abstract: A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises peripheral aqueous solution compartments formed between the lipid bilayers and a central lipophilic core compartment substantially at the center of the multilamellar lipid vesicle.
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