Patents Assigned to PHARMAENGINE, INC.
  • PHARMACEUTICAL SALTS OF A CHK-1 INHIBITOR
    Publication number: 20240360101
    Abstract: The invention provides a pharmaceutically acceptable salt of 5-[[5-[4-(4-fluoro-1-methyl-4-piperidyl)-2-methoxy-phenyl]-1H-pyrazol-3-yl]amino]pyrazine-2-carbonitrile which is selected from maleate, tosylate, besylate and malonate salts. Also provided are particular crystalline forms of the salts, methods for the preparation of the salts, pharmaceutical compositions containing the salts and their therapeutic uses.
    Type: Application
    Filed: June 1, 2022
    Publication date: October 31, 2024
    Applicants: SENTINEL ONCOLOGY LIMITED, PHARMAENGINE, INC.
    Inventors: Meriel MAJOR, Stuart TRAVERS, Jake PARKER, Julian NORTHEN
  • PREPARATION OF A CHK1 INHIBITOR COMPOUND
    Publication number: 20240287035
    Abstract: The invention provides a novel synthetic route for the preparation of the Chk-1 inhibitor compound: as well as novel process intermediates per se.
    Type: Application
    Filed: June 1, 2022
    Publication date: August 29, 2024
    Applicants: SENTINEL ONCOLOGY LIMITED, PHARMAENGINE, INC.
    Inventors: Stuart TRAVERS, Meriel MAJOR, Derek John LONDESBROUGH, Richard CHUBB
  • 3,5-disubstituted pyrazoles useful as checkpoint kinase 1 (Chk1) inhibitors, and their preparations and applications
    Patent number: 11116767
    Abstract: The present invention provides compounds of formula (I) which are potent inhibitors of Chk1 and have the structural formula below: wherein R1, R2, R3, R4, and R5 are as defined herein. Pharmaceutical compositions comprising the compounds, uses thereof and their preparation process are also provided.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: September 14, 2021
    Assignee: PHARMAENGINE, INC.
    Inventors: Xiong Cai, Changgeng Qian, Yanong Daniel Wang
  • 3,5-DISUBSTITUTED PYRAZOLES USEFUL AS CHECKPOINT KINASE 1 (CHK1) INHIBITORS, AND THEIR PREPARATIONS AND APPLICATIONS
    Publication number: 20210137918
    Abstract: The present invention provides compounds of formula (I) which are potent inhibitors of Chk1 and have the structural formula below: wherein R1, R2, R3, R4, and R5 are as defined herein. Pharmaceutical compositions comprising the compounds, uses thereof and their preparation process are also provided.
    Type: Application
    Filed: February 4, 2016
    Publication date: May 13, 2021
    Applicant: PHARMAENGINE, INC.
    Inventors: Xiong CAI, Changgeng QIAN, Yanong Daniel WANG