Abstract: In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35° C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.
Type:
Grant
Filed:
July 8, 2010
Date of Patent:
April 17, 2012
Assignee:
PharmaKodex Limited
Inventors:
John Nicholas Staniforth, Michael John Tobyn
Abstract: An applicator for applying a spreadable composition to the skin or other exterior region of a human or animal body, comprising receiving means for receiving and carrying a unit or measured dose of the composition and a grip for enabling a user to grip and manipulate the applicator, wherein the grip and receiving means are arranged such that a user gripping the applicator by the grip is protected from inadvertent contact with a composition, a unit or measured dose of which is carried by the receiving means.
Type:
Grant
Filed:
May 6, 2003
Date of Patent:
April 19, 2011
Assignee:
Pharmakodex Limited
Inventors:
John Staniforth, Michael Tobyn, Sharon Ann Mills, Christopher John Althorpe
Abstract: In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35° C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.
Type:
Application
Filed:
July 8, 2010
Publication date:
October 28, 2010
Applicant:
Pharmakodex Limited
Inventors:
John Nicholas Staniforth, Michael John Tobyn
Abstract: In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35° C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.
Type:
Grant
Filed:
June 26, 2001
Date of Patent:
July 13, 2010
Assignee:
Pharmakodex Limited
Inventors:
John Nicholas Staniforth, Michael John Tobyn
Abstract: The present invention relates to improved compositions for transmucosal administration, the compositions enabling rapid and efficient uptake of a therapeutically active agent to provide a rapid, effectively durable, predictable and consistent therapeutic effect. In particular, the compositions are intended for buccal and/or sublingual delivery. The invention is particularly suitable for administering therapeutically active agents which have an effect on the central nervous system and even more particularly where rapid onset of this effect is desired or beneficial. The invention is also particularly suitable for administering active agents in low solubility base or acid forms.
Abstract: In certain embodiments, the present invention is directed to a pharmaceutical formulation for topical administration on a mammal, comprising a unit dose of a therapeutically effective amount of a therapeutic agent and a pharmaceutically acceptable carrier medium therefor, said formulation being solid at ambient temperature and having a softening point of not higher than 35° C., such that when the formulation is placed in continuous contact with the skin of a mammalian patient, it is softened to a consistency to effect substantial application of the unit dose of said therapeutic agent onto a desired skin area of the mammalian patient within a time period of less than 10 minutes.
Type:
Application
Filed:
March 19, 2008
Publication date:
July 10, 2008
Applicant:
PharmaKodex Limited
Inventors:
John Nicholas Staniforth, Michael John Tobyn