Abstract: The invention concerns a method for selectively extracting furan lipids and polyhydroxylated fatty alcohols of avocado, characterised in that it comprises steps which consist in: preparing an unsaponifiable matter of avocado; then in subjecting the unsaponifiable matter of avocado to a step of molecular distillation using adjusted temperature and pressure means to obtain either a distillate comprising mainly furan lipids and polyhydroxylated fatty alcohols of avocado. Said method enables in particular to extract selectively furan lipids of avocado having a furan lipid content of more than 80 wt. %, even close to 98%.
Type:
Grant
Filed:
March 20, 2002
Date of Patent:
June 24, 2003
Assignee:
Pharmascience
Inventors:
Nicole Broutin, Jacques Legrand, Antoine Piccirilli
Abstract: Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically acceptable salts, solvates, hydrates, esters and isomers thereof. The described formulations include a propellant selected from the group consisting of a fluorocarbon propellant, a hydrogen-containing fluorocarbon propellant, and mixtures thereof. The formulations are substantially free of both surfactant and solvent. Methods of use and drug delivery devices are also provided.
Type:
Grant
Filed:
April 23, 2001
Date of Patent:
September 24, 2002
Assignee:
Pharmascience
Inventors:
Harold Wulffhart, Khaldoun Ayoub, Rosemary Logiudice, Hanna Piskorz
Abstract: A method is provided for preventing or treating skin conditions, disorders or diseases, such as may be associated with or caused by inflammation, sun damage or natural aging. The method involves administration, preferably topical administration, of an active agent selected from the group consisting of resveratrol, pharmacologically acceptable salts, esters, amides, prodrugs and analogs thereof, and combinations of any of the foregoing. Pharmaceutical formulations for use in conjunction with the aforementioned method are provided as well.
Type:
Grant
Filed:
October 29, 1999
Date of Patent:
July 2, 2002
Assignee:
Pharmascience
Inventors:
John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang, Aomar Ouali, Shengzhao Lin, Karla Slowing Barillas
Abstract: A composition and method of cancer chemoprevention is disclosed. The composition and method utilize resveratrol as a cancer chemopreventative agent in mammals, including humans.
Type:
Grant
Filed:
January 9, 1998
Date of Patent:
December 28, 1999
Assignee:
Pharmascience
Inventors:
John M. Pezzuto, Richard C. Moon, Mei-Shiang Jang