Patents Assigned to Pharmasonics
  • Methods, systems, and kits for intravascular nucleic acid delivery
    Patent number: 6794369
    Abstract: Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm2 to 100 W/cm2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.
    Type: Grant
    Filed: August 9, 2002
    Date of Patent: September 21, 2004
    Assignee: Pharmasonics
    Inventors: Christopher M. H. Newman, Axel F. Brisken