Patents Assigned to Pharmathene, Inc.
  • Anthrax vaccine formulation and uses thereof
    Patent number: 9616117
    Abstract: An anthrax vaccine with alhydrogel as the adjuvant is presented in a composition formulated by mixing rPA with colloidal alhydrogel (alum) adjuvant to produce the final product, comprising 200 ?g/ml rPA bound to 0.26% alhydrogel in phosphate buffered saline (PBS), said formulation containing an optimal concentration of phosphate. Methods of using the vaccines to treat or prevent infections are also presented.
    Type: Grant
    Filed: October 2, 2009
    Date of Patent: April 11, 2017
    Assignee: PharmAthene, Inc.
    Inventors: Allan Watkinson, David Woodhouse, Robert Wilson
  • Recombinant butyrylcholinesterases and truncates thereof
    Patent number: 8952143
    Abstract: Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed.
    Type: Grant
    Filed: April 3, 2014
    Date of Patent: February 10, 2015
    Assignee: PharmAthene, Inc.
    Inventors: Kalvin Yim, Steven Danso, Edward Hausknecht
  • Recombinant butyrylcholinesterases and truncates thereof
    Patent number: 8729245
    Abstract: Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: May 20, 2014
    Assignee: Pharmathene, Inc.
    Inventors: Kalvin Yim, Steven Danso, Edward Hausknecht