Abstract: Methods of using phosphotetrahydropyran compounds for treatment of fibrotic and scarring disorders, e.g. pulmonary fibrosis, fibrosis associated with surgical procedures, wound healing disorders, scar formation, sclerotic disorders, ocular fibrotic disorders, ocular healing disorders, ocular fibrosis after surgery, glaucoma, tendon scarring disorders, joint scarring disorders, kidney interstitial fibrosis and glomerular fibrosis and tubular fibrosis of the kidney.
Type:
Grant
Filed:
April 28, 2010
Date of Patent:
October 15, 2013
Assignee:
Pharmaxis Pty Limited
Inventors:
Alan D. Robertson, Diego Silva, Ian Alexander McDonald
Abstract: Methods of using phosphotetrahydropyran compounds for treatment of fibrotic and scarring disorders, e.g. pulmonary fibrosis, fibrosis associated with surgical procedures, wound healing disorders, scar formation, sclerotic disorders, ocular fibrotic disorders, ocular healing disorders, ocular fibrosis after surgery, glaucoma, tendon scarring disorders, joint scarring disorders, kidney interstitial fibrosis and glomerular fibrosis and tubular fibrosis of the kidney.
Type:
Application
Filed:
April 28, 2010
Publication date:
February 23, 2012
Applicant:
Pharmaxis Pty Limited
Inventors:
Alan D. Robertson, Diego Silva, Ian Alexander McDonald
Abstract: Novel phosphotetrahydropyran compounds that mimic mannose-6-phosphate but that are more resistant to phosphatases and mannosidases, and pharmaceutical compositions thereof, are disclosed. These compounds and compositions inhibit T lymphocyte migration from blood to tissues or to other extravascular sites. By inhibiting such migration, these compounds are useful for treating diseases or disorders that are mediated at least in part by such T lymphocyte migration. Such diseases and disorders include rheumatoid arthritis, multiple sclerosis, acute disseminated encephalomyelitis, psoriasis, inflammatory bowel disease, T cell-mediated dermatitis, stromal keratitis, uveitis, thyroiditis, sialitis and type I diabetes.
Type:
Grant
Filed:
May 20, 2004
Date of Patent:
January 19, 2010
Assignee:
Pharmaxis Pty Limited
Inventors:
William Butler Cowden, Gavin James Bartell, Bart Michael Eschler, Darren Ray March, Alan Robertson