Abstract: An orally dissolving film (ODF) is adapted to adhere to an oral mucosal tissue or gum tissue of a subject and a method for preparing the ODF. The ODF contains wells that can be filled with one or more pharmaceutical agents. The agents can be filled during the ODF production or before administration to allow personal dosing and agent combinations.
Abstract: Disclosed is a dissolvable film adapted to adhere to an oral mucosal tissue of a subject, wherein the film comprises at least three indigestible hydrophilic polymers constituting from 35% to 55% of the film dry weight and wherein the at least three polymers comprise xanthan gum and carboxymethyl cellulose (CMC) in a weight ratio of between 1:0.8-1.6, and at least one other cellulose based polymer. Optionally, the film may further include an active agent in an amount of 0.01% to 35% of the film dry weight. Disclosed also is a method for preparing the film and a method for treating or preventing oral conditions comprising implementing the film. Particularly, the film may be applied between dentures and the gums of the user.
Type:
Grant
Filed:
July 31, 2017
Date of Patent:
May 11, 2021
Assignee:
PHARMEDICA LTD.
Inventors:
Yoram Rubin, David Tavor, Hock Tan, Odeya Tairy
Abstract: Disclosed is a dissolvable film adapted to adhere to an oral mucosal tissue of a subject, wherein the film comprises at least three indigestible hydrophilic polymers constituting from 35% to 55% of the film dry weight and wherein the at least three polymers comprise xanthan gum and carboxymethyl cellulose (CMC) in a weight ratio of between 1:0.8-1.6, and at least one other cellulose based polymer. Optionally, the film may further include an active agent in an amount of 0.01% to 35% of the film dry weight. Disclosed also is a method for preparing the film and a method for treating or preventing oral conditions comprising implementing the film. Particularly, the film may be applied between dentures and the gums of the user.
Type:
Application
Filed:
July 31, 2017
Publication date:
July 11, 2019
Applicant:
PHARMEDICA LTD.
Inventors:
Yoram RUBIN, David TAVOR, Hock TAN, Odeya TAIRY
Abstract: Provided are orally administrable thin film dosage forms adapted to adhere to a mucosal tissue of a patient, wherein said film comprises mixtures of polymers and insulin.
Abstract: Provided are orally administrable thin film dosage forms adapted to adhere to a mucosal tissue of a patient, wherein said film comprises mixtures of polymers and insulin.