Abstract: A method of selecting a collection of cells for choosing a fetal bovine serum (FBS) to use in stem cell transplantation is provided. In addition, a method of selecting a fetal bovine serum (FBS) for use in culturing stem cells for transplantation is provided. Furthermore, a culture medium for culturing stem cells for transplantation and a method of stem cell transplantation are provided.
Type:
Application
Filed:
April 7, 2014
Publication date:
October 8, 2015
Applicant:
PHARMICELL CO., LTD.
Inventors:
Yoon Mi Kang, Ha Cheol Shin, Yong Man Kim, Wan Seok Joo, Hyun Soo Kim
Abstract: The present invention pertains to methods of using protein tyrosine kinase (PTK) inhibitors for inducing cell differentiation of mesenchymal stem cells into cardiac cells, and a pharmaceutical composition comprising the differentiated cardiac cells thereof to treat heart diseases. The transplantation of mesenchymal stem cells to the heart provides immunological and functional improvements, but does not provide electrical stability. However, the mesenchymal stem cells treated with PTK inhibitors are induced to be differentiated into cardiogenic cells to provide electrical stability as the electromechanical integration with host heart tissue is improved, and it is thus possible to effectively treat cardiac diseases such as cardiac infarction, cardiac insufficiency, arrhythmia and the like.
Abstract: The present invention provides a method of differentiating and proliferating a mesenchymal stem cell into the neural cell by culturing in a medium comprising an epidermal growth factor and a hepatocyte growth factor after confluent culture of the mesenchymal stem cell. The present invention provides more effective method of differentiating and proliferating the mesenchymal stem cell or the mononuclear cell comprising the mesenchymal stem cell into the neural cell with a neuron and an astrocyte in terms of time, efficiency and maturity as compared with conventional methods.
Type:
Grant
Filed:
October 29, 2003
Date of Patent:
December 22, 2009
Assignees:
FCB Pharmicell Co., Ltd.
Inventors:
Hyun-Soo Kim, Young-Mo Kang, Kyung-Bock Lee, Sang-Kyo Park, Sang-Kap Lee
Abstract: Lymphoid dendritic cells with immunophenotype CD8?+ can be produced by a method which comprises culturing human hematopoietic stem cells in a medium containing GM-CSF, followed by culturing in a medium containing IFN-?, the lymphoid dendritic cells being useful in various immunotherapies.
Abstract: The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.
Type:
Grant
Filed:
March 24, 2004
Date of Patent:
June 24, 2008
Assignee:
FCB-Pharmicell Co., Ltd.
Inventors:
Gwang Lee, Young Hwan Ahn, Ki Ho Park, Hong Ki Jun
Abstract: A method for differentiating mesenchymal stem cells of bone marrow into neural cells comprises culturing the mesenchymal stem cells in a medium containing epidermal growth factor(EGF), basic fibroblast growth factor(bFGF) and hepatocyte growth factor(HGF), and the neural cells produced thereby can be employed for the treatment of a neural disease.
Type:
Grant
Filed:
April 19, 2002
Date of Patent:
June 12, 2007
Assignees:
FCB-Pharmicell Co., Ltd., LifeCord International Co., Ltd.