Abstract: Disclosed is a method of producing a test strip for detecting a calcium level in a body fluid test sample obtained from a biological subject such as a human or animal. Also disclosed is a test strip that is useful for determining the concentration of calcium in a human or animal body fluid test sample based on a colorimetric change, and thus provides early detection of osteoporosis by monitoring the calcium excretion rate in an easy and inexpensive manner.

Abstract: A composition including insulin and a triple agonist having activity with respect to all of a glucagon receptor, GLP-1 receptor, and GIP receptor is disclosed. A composite preparation including the composition is also disclosed.

Abstract: A sericin-containing composition for treatment, prevention, or alleviation of fatty liver and a method of preparing the same.

Abstract: A surgical tool having an integrated orthopedic anchor and an anchor coupler are proposed. When an anchor (100) is coupled and fixed to an anchor coupling portion (220) of an anchor coupler (200), arc recesses (130a) formed in through-holes (130) and arc recesses (221a) formed at an anchor coupling portion (220) are fitted to each other, so suture insertion holes (20) aligned with holes in the anchor coupling portion (220) and having wide inlets are formed and a suture (10) may be easily connected. Further, when the anchor coupler (200) is rotated and pressed in surgery, the protruding front ends (221) separated at the anchor coupling portion (220) and protruding through the through-holes (130) at both sides of the front end of the anchor body (110) bore a bone tissue while covering an outer surface of the front end portion of the anchor (100).

Abstract: The present invention relates to a pharmaceutical composition containing an avocado oil fraction as an active ingredient for prevention or treatment of hearing loss. Specifically, the avocado oil fraction according to the present invention, especially, an isopropanol fraction of avocado oil significantly increases the number of hair cells reduced by neomycin in zebrafish models, so the isopropanol fraction of avocado oil can be favorably used in the treatment of hearing loss.

Abstract: Disclosed is a method for extracting high-purity polydeoxyribonucleotide (PDRN) from salmon testes, including 1) separating semen and immature testicular regions from the testes of a salmonid fish, 2) gently grinding the immature testicular regions, followed by dilution with an artificial seminal plasma, 3) treating the dilution with a predetermined concentration of human chorionic gonadotropin (hCG) to induce artificial sexual maturation of the testicular cells to sperm, 4) centrifuging the testicular dilution after the passage of a predetermined time from the hCG treatment and collecting potentially motile sperm, and 5) extracting PDRN from the collected sperm. The method enables the production of raw materials for PDRN with a 100- to 200-fold higher purity from 20 mL (a maximum of 50 mL) of sperm (semen) collected at one time from a salmonid fish. In addition, the method enables the extraction of PDNR in high yield in a cost-effective and economically viable manner.

Abstract: Provided are a composition and a complex formulation, each including insulin or a long-acting conjugate thereof and glucagon or a long-acting conjugate thereof.

Abstract: The present invention relates to a phenyl alkyl carbamate compound for use in preventing or treating neurodegenerative diseases. The phenyl alkyl carbamate compound of the present invention, prevented dopaminergic neuron loss, attenuated activation of astrocyte/microglia, repressed phosphorylated alpha-synuclein, and regulated phosphorylation levels of tau and acetylation levels of alpha-tubulin in the Parkinson's disease animal model. In addition, the phenyl alkyl carbamate compound of the present invention reduced the Amyloid-beta precursor protein and Amyloid-beta. Therefore, the phenyl alkyl carbamate compound of the present invention may be effectively used for preventing or treating neurodegenerative diseases.

Abstract: A glucagon derivative, a long-acting conjugate of the glucagon derivative, and a use thereof are disclosed.

Abstract: The present invention relates to a long-circulating liposome modified with c(RGD-ACP-K). The present invention pertains to the field of pharmaceutical preparations, in particular to the field of targeted pharmaceutical preparations. More specifically, the present invention relates to a long-circulating liposome, the surface of the liposome being modified with c(RGD-ACP-K), and the liposome comprising doxorubicin or a pharmaceutically acceptable salt thereof such as doxorubicin hydrochloride as an anti-cancer active agent. The long-circulating liposome can targetedly deliver the anti-cancer active agent into tumor neovascular endothelial cells and tumor cells and can prolong the circulation time of the liposome in vivo, thereby enhancing the therapeutic effect of anti-tumor medicaments.

Abstract: The present invention relates to a novel peptide of a glucagon derivative and a composition for preventing or treating obesity comprising the peptide as an active ingredient. The glucagon derivative according to the present invention shows a more excellent activating effect with regard to both glucagon-like peptide-1 receptors and glucagon receptors compared to native glucagon, and thus can be widely used as an effective agent for treating obesity.

Abstract: Provided is a compound represented by Formula 1 having an inhibitory activity on lysine-specific demethylase-1 (LSD1), an optical isomer, a solvate, a tautomer, or a pharmaceutically acceptable salt thereof, which is effective in preventing or treating a disease caused by abnormal activation of LSD1.

Abstract: The present invention relates to therapeutic uses of a triple agonist having activities to all of glucagon, GLP-1, and GIP receptors, and long-acting conjugates thereof for liver disease.

Abstract: The present disclosure relates to a novel method for preparing apixaban. The method of the present disclosure is economical since no expensive reagents or solvents are used. In addition, the method is applicable to mass production on an industrial scale because it requires no special conditions or complicated processes and no hazardous reagents or solvents are used. Furthermore, because no toxic solvent is used in the final step of apixaban synthesis and in a purification process, high-purity apixaban can be prepared stably at high yield without the concern of residual solvents.

Abstract: Provided are a crosslinked hyaluronic acid product in the form of powder and a method of preparing the same, and a crosslinked hyaluronic acid hydrogel prepared using the crosslinked hyaluronic acid product in the form of powder, and a method of preparing the same. The crosslinked hyaluronic acid hydrogel according to the present disclosure exhibits excellent rheological properties, and mass production thereof is easy and quality uniformity thereof is excellent.

Abstract: The present invention relates to an interleukin-2 analogue, which has altered binding affinity for interleukin-2 alpha receptor and interleukin-2 beta receptor, compared to the wild type.

Abstract: Disclosed are an acid-resistant pharmaceutical composition including tamsulosin hydrochloride, and a method of preparing the same. The pharmaceutical composition is formulated into tablets by preparing core beads including tamsulosin hydrochloride as an active ingredient, coating the core beads with an entering coating solution including a specific amount of plasticizer, adding a post mixture portion including a buffer to adjust density and a lubricant to the enteric-coated core beads, and performing tableting. The enteric coating layer is not broken during the tableting process. Thus, the acid resistance of the pharmaceutical composition is maintained. The pharmaceutical composition can be easily formulated into tablets, ensures good uniformity of dosage unit, lowers dissolution rate of tamsulosin hydrochloride, has good acid resistance, and is stable not to exhibit signification decomposition of tamsulosin hydrochloride.

Abstract: Provided is a novel pyrrolopyridine compound represented by Chemical Formula I, a racemate or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and to a method for preparing the same. A compound represented by Chemical Formula I shows high selectivity and antiviral activity against human immunodeficiency virus (HIV), with low toxicity; therefore, it is useful as a therapeutic agent for viral infection, in particular, HIV infection.

Abstract: Provided is a complex composition, of which positional isomers are minimized by using a N-terminus of an immunoglobulin Fc region as a binding site when the immunoglobulin Fc region is used as a carrier. Also provided are a protein complex which is prepared by N-terminal-specific binding of immunoglobulin Fc region, thereby prolonging blood half-life of the physiologically active polypeptide, maintaining in vivo potency at a high level, and having no risk of immune responses, a preparation method thereof, and a pharmaceutical composition including the same for improving in vivo duration and stability of the physiologically active polypeptide. The protein complex may be usefully applied to the development of long-acting formulations of various physiologically active polypeptide drugs.

Abstract: Provided are a combination of cross-linked hyaluronic acids comprising: a cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa, and a cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa, and a method for preparing the same.