Patents Assigned to Pharmion LLC
  • Synthesis of 5-azacytidine
    Patent number: 9951098
    Abstract: Provided herein are processes for the preparation of 5-azacytidine, useful for treating, preventing, and/or managing diseases or conditions including cancer, disorders related to abnormal cell proliferation, hematologic disorders, and myelodysplastic syndromes (MDS), wherein 5-azacytidine is represented by the structure:
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: April 24, 2018
    Assignee: Pharmion LLC
    Inventors: Chinnapillai Rajendiran, Periyandi Nagarajan, Jasti Venkateswarlau
  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 9192620
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: November 24, 2015
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Lee Alani Selvey
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 8975392
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: June 7, 2013
    Date of Patent: March 10, 2015
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Lee Alani Selvey
  • Pharmaceutical compositions comprising 5-azacytidine monohydrate
    Patent number: 8779117
    Abstract: Provided herein are pharmaceutical compositions or dosage forms comprising crystalline 5-azacytidine monohydrate. The pharmaceutical compositions or dosage forms provided herein may be used for oral administration in the treatment of diseases, including the treatment of myelodysplastic syndromes (MDS).
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: July 15, 2014
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20140107058
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacyditine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 17, 2014
    Applicant: PHARMION LLC
    Inventors: Dumitru IONESCU, Peter BLUMBERGS, Lee Alani SELVEY
  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 8614313
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: December 24, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Pharmaceutical compositions comprising forms of 5-azacytidine
    Patent number: 8513406
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: August 20, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Methods for isolating crystalline form I of 5-azacytidine
    Patent number: 8481715
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: July 9, 2013
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20130059810
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: August 16, 2012
    Publication date: March 7, 2013
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • PHARMACEUTICAL COMPOSITIONS COMPRISING FORMS OF 5-AZACYTIDINE
    Publication number: 20130059809
    Abstract: The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
    Type: Application
    Filed: August 16, 2012
    Publication date: March 7, 2013
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • METHODS FOR ISOLATING CRYSTALLINE FORM I OF 5-AZACYTIDINE
    Publication number: 20120245342
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Application
    Filed: June 5, 2012
    Publication date: September 27, 2012
    Applicant: PHARMION LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • Pharmaceutical compositions comprising crystal forms of 5-azacytidine
    Patent number: 8211862
    Abstract: The invention includes methods for isolating crystalline Form I of 5-azacytidine substantially free of other forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising Form I of 5-azacytidine.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: July 3, 2012
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs, Gary L. Silvey
  • SYNTHESIS OF 5-AZACYTIDINE
    Publication number: 20120029181
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Application
    Filed: October 13, 2011
    Publication date: February 2, 2012
    Applicant: Pharmion LLC
    Inventors: Dumitru IONESCU, Peter BLUMBERGS
  • Synthesis of 5-azacytidine
    Patent number: 8058424
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: November 15, 2011
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs
  • Synthesis of 5-azacytidine
    Patent number: 7858774
    Abstract: The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected ?-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
    Type: Grant
    Filed: September 10, 2008
    Date of Patent: December 28, 2010
    Assignee: Pharmion LLC
    Inventors: Dumitru Ionescu, Peter Blumbergs