Abstract: A combination of a pro-agonist first medication in timed release form, and a sequestered second non-antagonist medication allows the first medication to be effective if taken according to medical directions. If the combination is tampered with or otherwise taken in a manner not according to medical directions, the second medication is released and prevents the first medication from becoming effective. The non-antagonist second medication does not precipitate immediate withdrawal in a dependent patient.

Abstract: Pharmaceutical dosage forms are provided for use in deterring abuse of opioids or other medications, which help avoid harm to a patient dependent on the medication. In one case, a pharmaceutical oral dosage form is provided that includes a plurality of microcapsules, each microcapsule of the plurality containing an opioid agonist medication in a controlled release form, and a partial opioid agonist sequestered in the pharmaceutical dosage form, such that upon oral administration of the pharmaceutical oral dosage form the partial opioid agonist will pass through the gastrointestinal tract without uptake by the body.