Patents Assigned to PHASERX, INC.
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Patent number: 10066043Abstract: Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ?-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.Type: GrantFiled: February 8, 2017Date of Patent: September 4, 2018Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Scott M. Henry, Robert W. Overell, Paul H. Johnson
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Patent number: 9867885Abstract: Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.Type: GrantFiled: July 30, 2014Date of Patent: January 16, 2018Assignee: PhaseRx, Inc.Inventors: Sean D Monahan, Michael S Declue, Pierrot Harvie, Russell N Johnson, Amber E Paschal, Mary G Prieve, Debashish Roy, Charbel Diab, Michael E Houston, Jr., Anna Galperin, Maher Qabar
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Patent number: 9862792Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.Type: GrantFiled: September 13, 2016Date of Patent: January 9, 2018Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
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Publication number: 20170239360Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.Type: ApplicationFiled: April 27, 2017Publication date: August 24, 2017Applicants: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Patent number: 9662403Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.Type: GrantFiled: March 2, 2016Date of Patent: May 30, 2017Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20170145141Abstract: Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ?-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.Type: ApplicationFiled: February 8, 2017Publication date: May 25, 2017Applicants: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Scott M. Henry, Robert W. Overell, Paul H. Johnson
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Publication number: 20170096517Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.Type: ApplicationFiled: September 13, 2016Publication date: April 6, 2017Applicants: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
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Patent number: 9593169Abstract: Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ?-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.Type: GrantFiled: December 8, 2009Date of Patent: March 14, 2017Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Scott M. Henry, Robert W. Overell, Paul H. Johnson
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Publication number: 20170049801Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.Type: ApplicationFiled: September 1, 2016Publication date: February 23, 2017Applicants: University of Washington, PhaseRx, Inc.Inventors: Mary G. Prieve, Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert W. Overell, Anna S. Gall, Amber E.E. Paschal, Charbel Diab, Priyadarsi De, Michael S. DeClue, Sean D. Monahan
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Patent number: 9476063Abstract: Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic.Type: GrantFiled: May 13, 2009Date of Patent: October 25, 2016Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Danielle Benoit, Craig L. Duvall, Paul H. Johnson, Anna S. Gall
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Patent number: 9464300Abstract: Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof.Type: GrantFiled: November 6, 2009Date of Patent: October 11, 2016Assignees: University of Washington, PhaseRx, Inc.Inventors: Mary G. Prieve, Paul H. Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert W. Overell, Anna S. Gall, Amber E. E. Paschal, Charbel Diab, Priyadarsi De, Michael S. DeClue, Sean D. Monahan
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Publication number: 20160250338Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.Type: ApplicationFiled: March 2, 2016Publication date: September 1, 2016Applicants: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Patent number: 9415113Abstract: Provided herein are monomers incorporating folate or other targeting agent, polymers prepared therefrom, polymers prepared therefrom having a therapeutic agent covalently coupled thereto, as well as micelles and therapeutic compositions thereof.Type: GrantFiled: November 17, 2010Date of Patent: August 16, 2016Assignees: University of Washington, PhaseRx, Inc.Inventors: Sean D. Monahan, Paul H. Johnson, Michael S. DeClue, Priyadarsi De, Anna S. Gall, Patrick S. Stayton, Allan S. Hoffman, Charbel Diab
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Patent number: 9339558Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles.Type: GrantFiled: May 13, 2009Date of Patent: May 17, 2016Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20160082121Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.Type: ApplicationFiled: December 2, 2015Publication date: March 24, 2016Applicants: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
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Patent number: 9220791Abstract: A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target.Type: GrantFiled: February 5, 2014Date of Patent: December 29, 2015Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Robert Overell, Paul Johnson
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Patent number: 9211250Abstract: Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent.Type: GrantFiled: May 13, 2009Date of Patent: December 15, 2015Assignees: University of Washington, PhaseRx, Inc.Inventors: Paul Johnson, Patrick S. Stayton, Allan S. Hoffman, Robert Overell, Anna Gall, Mary Prieve, Amber Paschal, Charbel Diab, Priyadarsi De
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Publication number: 20150291956Abstract: A double stranded RNA (dsRNA) molecule targeted to beta catenin includes a duplex region having a sense region and an antisense region at least substantially complementary to the sense region. The sense region and the antisense region each have between 18 and 30 nucleotides. The antisense region includes a nucleotide sequence that is fully complementary to at least 15 contiguous nucleotides of any one of SEQ ID NOs: 1-24.Type: ApplicationFiled: February 19, 2013Publication date: October 15, 2015Applicant: PHASERX, INC.Inventors: Markus Hossbach, Jochen Deckert
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Publication number: 20150238619Abstract: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g., oligonucleotides) and/or other therapeutic agents into a living cell.Type: ApplicationFiled: February 24, 2015Publication date: August 27, 2015Applicants: PHASERX, INC., UNIVERSITY OF WASHINGTONInventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E.E. Paschal, Charbel Diab, Priyadarsi De
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Patent number: 9006193Abstract: Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell.Type: GrantFiled: May 13, 2009Date of Patent: April 14, 2015Assignees: University of Washington, PhaseRx, Inc.Inventors: Patrick S. Stayton, Allan S. Hoffman, Anthony J. Convertine, Craig L. Duvall, Danielle Benoit, Robert W. Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De